Serum Ionized Calcium and Dietary Calcium in Human and Experimental Hypertension

  • David A. McCarron
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 178)


Calcium and its binding protein, calmodulin, exert multiple effects that serve to regulate blood pressure in humans. From experimental work in various organ systems and cell types that are integrated to control cardiovascular function, it is evident that calcium and the calcium-calmodulin complex are essential components of diverse physiologic processes that modulate arterial pressure. The abnormal peripheral resistance that underlies essential hypertension is principally a reflection of altered vascular smooth muscle basal tone and reactivity. As such, the vascular smooth cell is prototypical of calcium’s influence on blood pressure control.1


Calcium Intake Dietary Calcium Serum Calcium Concentration Serum Total Calcium Blood Pressure Profile 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • David A. McCarron
    • 1
  1. 1.Division of NephrologyOregon Health Sciences UniversityPortlandUSA

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