Effect of Calcium-Sodium Exchange and Calcium Channel Inhibition on Calcium Release from Bone in an in-vitro Bone Perfusion System

  • Peter J. Somerville
  • Michael Kaye
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 178)


The regulation of calcium release from bone is likely to be at least in part, dependant on cellular activity. In recent years it has been shown that the intracellular calcium concentration is important in regulating the activity of many cells from a wide range of tissues including those of the endocrine system and bone. There are several mechanisms involved in regulating cell calcium including calcium sodium (Ca-Na) exchange, calcium-magnesium sensitive ATPase and calcium transport via slow calcium channels1. Thus it is possible that by regulating intracellular calcium, some of these mechanisms could also regulate the cell mediated component of the transfer of calcium from bone to the extracellular fluid.


Calcium Release Calcium Transport Choline Chloride 45Ca Release Stimulate Bone Resorption 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Peter J. Somerville
    • 1
  • Michael Kaye
    • 1
  1. 1.Division of NephrologyMontreal General HospitalMontrealCanada

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