Verapamil Improves Defective Intestinal Calcium Absorption in Uremia

  • M. S. Goligorsky
  • C. Chaimovitz
  • Sh. Shany
  • J. Rapoport
  • Y. Sharony
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 178)


One of the recognized manifestations of renal insufficiency is a defect in intestinal absorption of calcium (1). There is substantial clinical and experimental evidence that this abnormality in intestinal absorption of calcium is secondary to uremia per se and to reduced ability of the diseased kidney to synthesize 1,25 (OH) 2vitamin D3 (2–5). Interestingly, this impairment of intestinal transport of calcium has been described even in early stages of renal insufficiency when other parameters of renal function are relatively well preserved, and when plasma levels of 1,25 (OH) 2vitamin D3 may be normal (5,6). Normal level of vitamin D in the face of reduced intestinal absorption of calcium suggests that renal lα-hydroxylase activity is relatively suppressed in early uremia (7).


Intestinal Absorption Intestinal Calcium Absorption Renal Calcium Lanthanum Chloride Duodenal Loop 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • M. S. Goligorsky
    • 1
    • 2
  • C. Chaimovitz
    • 1
    • 2
  • Sh. Shany
    • 1
    • 2
  • J. Rapoport
    • 1
    • 2
  • Y. Sharony
    • 1
    • 2
  1. 1.Dept. of NephrologySoroka University HospitalBeer-ShebaIsrael
  2. 2.Faculty of Health SciencesBen-Gurion Univ. of NegevBeer-ShebaIsrael

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