ATP as a Factor in the Response of the cAMP System to PTH in Proximal and Distal Convoluted Tubules
Since the discovery of cyclic 3′ ,5′-AMP (cAMP) as an intra-cellular mediator in hormone-responsive tissues by E. W. Sutherland (1), it was well recognized that ATP serves as a substrate for the key enzyme of cAMP metabolism—adenylate cyclase (AdC). Later it was also found that ATP may modulate cAMP catabolism by inhibiting cAMP-phosphodiesterase (cAMP-PDIE) (2). However, in recent years little attention was paid to cellular levels of ATP as a potential determinant of hormone-sensitive cAMP metabolism.
KeywordsDiabetes Insipidus Nephrogenic Diabetes Insipidus cAMP Accumulation Distal Convoluted Tubule Proximal Convoluted Tubule
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