ATP as a Factor in the Response of the cAMP System to PTH in Proximal and Distal Convoluted Tubules

  • Thomas P. Dousa
  • Gary M. Kiebzak
  • Ahad N. K. Yusufi
  • Eiji Kusano
  • Julie Braun-Werness
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 178)


Since the discovery of cyclic 3′ ,5′-AMP (cAMP) as an intra-cellular mediator in hormone-responsive tissues by E. W. Sutherland (1), it was well recognized that ATP serves as a substrate for the key enzyme of cAMP metabolism—adenylate cyclase (AdC). Later it was also found that ATP may modulate cAMP catabolism by inhibiting cAMP-phosphodiesterase (cAMP-PDIE) (2). However, in recent years little attention was paid to cellular levels of ATP as a potential determinant of hormone-sensitive cAMP metabolism.


Diabetes Insipidus Nephrogenic Diabetes Insipidus cAMP Accumulation Distal Convoluted Tubule Proximal Convoluted Tubule 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Thomas P. Dousa
    • 1
  • Gary M. Kiebzak
    • 1
  • Ahad N. K. Yusufi
    • 1
  • Eiji Kusano
    • 1
  • Julie Braun-Werness
    • 1
  1. 1.Nephrology Research Unit, Division of Nephrology and Internal Medicine, Department of Physiology and BiophysicsMayo ClinicRochesterUSA

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