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Active Calcium Transport in Frog Skin: Stimulation by Cyclic AMP

  • Ellie Kelepouris
  • Mortimer Civan
  • Zalman S. Agus
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 178)

Abstract

Cytosolic calcium activity is regulated at extremely low levels (10−7M). This is accomplished in part by maintenance of a balance between calcium entry and exit via Ca-Mg-ATPase activity and Na/Ca exchange as defined in red cells and excitable tissue.1 The distal nephron, in addition to maintaining cytosolic calcium activity must simultaneously regulate transepithelial calcium transport under the influence of parathyroid hormone and cyclic AMP.2 Little is known at present about cellular mechanisms which regulate this transport and the relationship of this process to cytosolic calcium regulation. In this report, we present preliminary data demonstrating CAMP sensitive active transepithelial calcium transport in frog skin.

Keywords

Calcium Entry Calcium Transport Frog Skin Distal Nephron Serosal Side 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    A. P. Borie, Control, modulation and regulation of cell calcium. Rev. Phys. Biochem. Pharm. 90: 13 (1981).CrossRefGoogle Scholar
  2. 2.
    Z. S. Agus, A. Wasserstein, and S. Goldfarb, PTH, calcitonin, cyclic nucleotides and the kidney. Ann. Rev. Physiol. 43: 583 (1981).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Ellie Kelepouris
    • 1
  • Mortimer Civan
    • 1
  • Zalman S. Agus
    • 1
  1. 1.Departments of Medicine and PhysiologyUniversity of Pennsylvania School of MedicinePhiladelphiaUSA

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