Active Calcium Transport in Frog Skin: Stimulation by Cyclic AMP
Cytosolic calcium activity is regulated at extremely low levels (10−7M). This is accomplished in part by maintenance of a balance between calcium entry and exit via Ca-Mg-ATPase activity and Na/Ca exchange as defined in red cells and excitable tissue.1 The distal nephron, in addition to maintaining cytosolic calcium activity must simultaneously regulate transepithelial calcium transport under the influence of parathyroid hormone and cyclic AMP.2 Little is known at present about cellular mechanisms which regulate this transport and the relationship of this process to cytosolic calcium regulation. In this report, we present preliminary data demonstrating CAMP sensitive active transepithelial calcium transport in frog skin.
KeywordsCalcium Entry Calcium Transport Frog Skin Distal Nephron Serosal Side
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