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Intracellular Processes that Affect Renal Phosphate Transport

  • Vincent W. Dennis
  • Peter C. Brazy
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 178)

Abstract

Studies of phosphate transport in the proximal renal tubule have focused recently on interactions with intracellular processes, especially oxidative metabolism and gluconeogenesis. Intracellular inorganic phosphate is essential for oxidative phosphorylation and participates in mitochondrial respiration. Gluconeogenesis liberates phosphate. This review will summarize our recent observations on changes in phosphate transport with metabolic inhibitors, metabolic substrates and changes in gluconeogenesis.

Keywords

Proximal Tubule Mitochondrial Respiration Metabolic Inhibitor Phosphate Transport Cortical Tubule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Gullans, S. R., Brazy, P. C., Dennis, V. W., and Mandel, L. J., 1982, Metabolic inhibitors: Effects on metabolism and transport in the proximal tubule, Am. J. Physiol. 243: F133–F140.Google Scholar
  2. Brazy, P. C., Balaban, R. S., Gullans, S. R., Mandel, L. J., and Dennis, V. W., 1980, Inhibition of metabolism: relative effects of arsenate on sodium phosphate and glucose transport by the rabbit proximal tubule, J. Clin. Invest.66:1211–1221.PubMedCrossRefGoogle Scholar
  3. Balaban, R. S., Dennis, V. W., and Mandel, L. J., 1981, Microfluorometric monitoring of NAD redox state in isolated perfused renal tubules. Am. J. Physiol. 240:F337–F342.PubMedGoogle Scholar
  4. Nagata, N., and Rasmussen, 1970, Parathyroid hormone, 3’5’ AMP, CA++, and renal gluconeogenesis, Proc. Natl. Acad. Sci., 65:368–374.PubMedCrossRefGoogle Scholar
  5. Cheng, L., and Sacktor, B., 1981, Sodium gradient-dependent phosphate transport in renal brush border membrane vesicles, J. Biol. Chem. 256:1556–1564.PubMedGoogle Scholar
  6. Brazy, P. C., Gullans, S. R., Mandel, L. J. and Dennis, V. W., 1982, Metabolic requirement for inorganic phosphate by the rabbit proximal tubule: evidence for a Crabtree effect, J. Clin. Invest. 70:53–62, 1982.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Vincent W. Dennis
    • 1
  • Peter C. Brazy
    • 1
  1. 1.Department of MedicineDuke University Medical CenterDurhamUSA

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