Intracellular Processes that Affect Renal Phosphate Transport

  • Vincent W. Dennis
  • Peter C. Brazy
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 178)


Studies of phosphate transport in the proximal renal tubule have focused recently on interactions with intracellular processes, especially oxidative metabolism and gluconeogenesis. Intracellular inorganic phosphate is essential for oxidative phosphorylation and participates in mitochondrial respiration. Gluconeogenesis liberates phosphate. This review will summarize our recent observations on changes in phosphate transport with metabolic inhibitors, metabolic substrates and changes in gluconeogenesis.


Proximal Tubule Mitochondrial Respiration Metabolic Inhibitor Phosphate Transport Cortical Tubule 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Vincent W. Dennis
    • 1
  • Peter C. Brazy
    • 1
  1. 1.Department of MedicineDuke University Medical CenterDurhamUSA

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