Intracellular Processes that Affect Renal Phosphate Transport
Studies of phosphate transport in the proximal renal tubule have focused recently on interactions with intracellular processes, especially oxidative metabolism and gluconeogenesis. Intracellular inorganic phosphate is essential for oxidative phosphorylation and participates in mitochondrial respiration. Gluconeogenesis liberates phosphate. This review will summarize our recent observations on changes in phosphate transport with metabolic inhibitors, metabolic substrates and changes in gluconeogenesis.
KeywordsProximal Tubule Mitochondrial Respiration Metabolic Inhibitor Phosphate Transport Cortical Tubule
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