Advertisement

Cis-Platin Induced Hypermagnesiuria and Hypercalciuria in Rats

  • V. Mavichak
  • N. L. M. Wong
  • J. H. Dirks
  • R. A. L. Sutton
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 178)

Abstract

Cisplatin (cis-diammine dichloroplatinum), an effective chemotherapeutic agent that is being increasingly used against solid tumors, frequently causes renal impairment and electrolyte disturbances in man, particularly hypomagnesemia and renal magnesium wasting (1,2,3,4). In one report, 76% of patients became hypomagnesemic during cisplatin therapy and of these 50% had remained persistently hypomagnesemic for as long as 3 years following discontinuation of cisplatin treatment (4). The pathogenesis and mechanism(s) of hypomagnesemia and inappropriate renal magnesium wasting induced by cisplatin is still unknown.

Keywords

Magnesium Diet Effective Chemotherapeutic Agent Magnesium Transport Normal Diet Group Renal Magnesium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    N.E. Madias, J.T. Harrington. Platinum nephrotoxicity, a review. American Journal of Medicine, Volume 65, p. 307 (1978).PubMedCrossRefGoogle Scholar
  2. 2.
    R.L. Schilsky, T. Anderson. Hypomagnesemia and renal magnesium wasting in patients receiving cisplatin. Annals of Internal Medicine, 90: 929 - 931 (1979).PubMedGoogle Scholar
  3. 3.
    J.D. Blachley, J.B. Hill. Renal and electrolyte disturbances associated with cisplatin. Ann. Intern. Med. 95: 628 - 632 (1981).Google Scholar
  4. 4.
    R.L. Schilsky, A. Barlock, R.F. Ozols. Persistent hypomagnesemia following cisplatin chemotherapy for testicular cancer. Cancer Treatment Reports Vol. 66; No. 9, p. 1767 (1982).Google Scholar
  5. 5.
    S. Carney, N.L.M. Wong, G.A. Quamme, J.H. Dirks. Effect of magnesium deficiency on renal magnesium and calcium transport in the rat. J. Clin. Invest. 65: 180, 1980.PubMedCrossRefGoogle Scholar
  6. 6.
    G.A. Quamme, J.H. Dirks. Magnesium transport in the nephron: (editorial reviews). Am. J. Phys. 239 (Renal Fluid Electrolyte Physiology 8): F393, 1980.Google Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • V. Mavichak
    • 1
  • N. L. M. Wong
    • 1
  • J. H. Dirks
    • 1
  • R. A. L. Sutton
    • 1
  1. 1.Department of MedicineUniversity of British ColumbiaVancouverCanada

Personalised recommendations