Early Renal Adaptation to Dietary Phosphorus Restriction

  • Barton S. Levine
  • Kiyoshi Kurokawa
  • Jack W. Coburn
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 178)


An important consequence of dietary phosphorus (P) restriction is the ability of the kidney to virtually clear the urine of phosphate (Pi) (1). This adaptation can occur in the normal, thyroparathyroidectomized (1), and vitamin D-deficient state (2). The adaptation has been demonstrated in isolated perfused proximal tubules (3) as well as in vesicles formed by tubule brush border membranes (BBM) of proximal tubules (4, 5), and has been demonstrated as early as two days in renal BBM of the pig (6). The underlying mechanism for this renal adaptation is unknown. Several reports have suggested that an increased alkaline phosphatase (A1Pase) in the BBM is responsible for increased Pi reabsorption during P-depletion (4, 5). Other studies suggest that the adaptation may occur without concomitant changes in AlPase and there is no causal relationship between the two phenomena (7, 8, 9). The present study was designed to assess how rapid renal adaptation by BBM vesicles (BBMV) to dietary P-restriction develops and whether significant changes in BBM AlPase activity occur prior to changes in BBMV Pi transport. The results demonstrate that Pi uptake by the BBMV increases within 4 hours after dietary P restriction preceding any detectable increase in the AlPase.


Brush Border Membrane Dietary Phosphorus Maltase Activity Renal Brush Border Membrane AlPase Activity 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Barton S. Levine
    • 1
    • 2
  • Kiyoshi Kurokawa
    • 1
    • 2
  • Jack W. Coburn
    • 1
    • 2
  1. 1.Nephrology Division, Research and Medical ServicesVA Wadsworth Medical CenterUSA
  2. 2.Department of MedicineUCLA School of MedicineLos AngelesUSA

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