Effect of 1,25-Dihydroxycholecalciferol on the Extra-Renal Handling of Inorganic Phosphate in Thyroparathyroidectomized but not in Intact Rats
1,25-dihydroxycholecalciferol (1,25(OH)2D3) and parathyroid hormone have been shown to act on fluxes of inorganic phosphate (Pi) in bone and gut levels1–6 and directly or indirectly in the kidney. These effects influence the level of Pi in the extracellular space (ECS).
KeywordsPhosphate Transport Renal Handling Plasma Calcium Concentration Intestinal Phosphate Absorption Extrarenal Handl
Unable to display preview. Download preview PDF.
- 1.L. Castillo, Y. Tanaka, and H.F. DeLuca, The mobilization of bone mineral by 1,25-dihydroxyvitamin D3 in hypophosphatemic rats, Endocrinology 97: 995–99’9 (1975).Google Scholar
- 2.D.B.N. Lee, M.W. Walling, U. Gafter, V. Silis, and J.W. Coburn, Calcium and inorganic phosphate transport in rat colon. Dissociated response to 1,25-dihydroxyvitamin D3, J. Clin. Invest. 65: 1326–1331 (1980).Google Scholar
- 6.T.H. Steele, J.E. Engle, Y. Tanaka, R.S. Lorenc, K.L. Dudgeon, and H.F. DeLuca, Phosphatemic action of 1,25-dihydroxyvitamin D3, Am. J. Physiol. 229: 489–495 (1975).Google Scholar
- 8.J.-P. Bonjour, and H. Fleisch, Calcium supply and renal handling of phosphate, Min.Electrol.Metab. 3: 261–267 (1980).Google Scholar
- 9.M. Davies, C.M. Taylor, L.F. Hill, and S.W. Stanbury, 1,25-ihydroxycholecalciferol in hypoparathyroidism, Lancet i, 55–59 (1977).Google Scholar
- 10.J.F. Rosen, A.R. Fleischman, L. inberg, J. Eisman, and H.F. DeLuca, 1,25-dihydroxycholecalciferol: its use in the long-term management of idiopathic hypoparathyroidism in children, J. Clin. Endocrinol. 45: 457–468 (1977).Google Scholar
- 11.J. Lemann jr„ W.J. Maierhofer, N.D. Adams, and R.W. Gray, Increased serum 1,25(OH)2D3 con-centrations fails to affect serum or urine posphate in humans, in: Regulation of phosphate and mineral, S.G. Massry, J.M. Letteri and E. Ritz (eds.) Plenum, New York and London (1982).Google Scholar
- 12.J.-P. Bonjour, U. Tröhler, R. Mühlbauer, C. Preston and H. Fleisch, Is there a bone-kidney link in the homeostasis of inorganic phosphate (Pi)? in: Phosphate Metabolism (Vol. 81 in Advances in Experimental Medicine and Biology). Proc. 2nd International Workshop on Phosphate, Heidelberg, 1976. S.G. Massry and E. Ritz, eds. Plenum Press, New York–London, (1977), pp. 319–322.Google Scholar
- 13.J.-P. Bonjour, J. Caverzasio, R. Mühlbauer, H. Fleisch, and U. Trechsel, Acute and chronic effects of vitamin D metabolites on the renal handling of phosphate, in: Vitamin D, Basic Research and its Clinical Application, A.W. Norman, K. Schaefer, D. v. Herrath, H.-G. Grigoleit, J.W. Coburn, H.F. DeLuca, E.B. Mawer and T. Suda, eds. W. de Gruyter, Berlin (1979), pp. 307–314.Google Scholar