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Effect of 1,25-Dihydroxycholecalciferol on the Extra-Renal Handling of Inorganic Phosphate in Thyroparathyroidectomized but not in Intact Rats

  • Ulrich Troehler
  • Jean-Philippe Bonjour
  • Herbert Fleisch
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 178)

Abstract

1,25-dihydroxycholecalciferol (1,25(OH)2D3) and parathyroid hormone have been shown to act on fluxes of inorganic phosphate (Pi) in bone and gut levels1–6 and directly or indirectly in the kidney. These effects influence the level of Pi in the extracellular space (ECS).

Keywords

Phosphate Transport Renal Handling Plasma Calcium Concentration Intestinal Phosphate Absorption Extrarenal Handl 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    L. Castillo, Y. Tanaka, and H.F. DeLuca, The mobilization of bone mineral by 1,25-dihydroxyvitamin D3 in hypophosphatemic rats, Endocrinology 97: 995–99’9 (1975).Google Scholar
  2. 2.
    D.B.N. Lee, M.W. Walling, U. Gafter, V. Silis, and J.W. Coburn, Calcium and inorganic phosphate transport in rat colon. Dissociated response to 1,25-dihydroxyvitamin D3, J. Clin. Invest. 65: 1326–1331 (1980).Google Scholar
  3. 3..
    R.R. Recker, S.G. Massry, J.R. Lau, and P.D. Saville, The hyperphosphatemic effect 4M disodium ethane-1-hydroxy-1,1-diphosphonate (EHDPTM)): renal handling of phosphorus and the renal response to parathyroid hormone, J. Lab. Clin. Med. 81: 258–266 (1973).PubMedGoogle Scholar
  4. 4.
    R. Rizzoli, H. Fleisch, and J.-P. Bonjour, Role of 1,25-dihydroxyvitamin D3 on intestinal phosphate absorption in rats with a normal vitamin D supply, J. Clin. Invest. 60: 639–647 (1977).PubMedCrossRefGoogle Scholar
  5. 5.
    M.W. Walling, Intestinal calcium and phosphate transport: differential responses in vitamin D and D3 metabolites, Am. J. Physiol. 233: E488 - E494 (1977).PubMedGoogle Scholar
  6. 6.
    T.H. Steele, J.E. Engle, Y. Tanaka, R.S. Lorenc, K.L. Dudgeon, and H.F. DeLuca, Phosphatemic action of 1,25-dihydroxyvitamin D3, Am. J. Physiol. 229: 489–495 (1975).Google Scholar
  7. 7.
    J.-P. Bonjour, C. Preston, and H. Fleisch, Effect of 1,25-dihydroxyvitamin D3 on the renal handling of Pi in thyroparathyroidectomized rats, J.Clin. Invest. 60: 1419–1428 (1977).CrossRefGoogle Scholar
  8. 8.
    J.-P. Bonjour, and H. Fleisch, Calcium supply and renal handling of phosphate, Min.Electrol.Metab. 3: 261–267 (1980).Google Scholar
  9. 9.
    M. Davies, C.M. Taylor, L.F. Hill, and S.W. Stanbury, 1,25-ihydroxycholecalciferol in hypoparathyroidism, Lancet i, 55–59 (1977).Google Scholar
  10. 10.
    J.F. Rosen, A.R. Fleischman, L. inberg, J. Eisman, and H.F. DeLuca, 1,25-dihydroxycholecalciferol: its use in the long-term management of idiopathic hypoparathyroidism in children, J. Clin. Endocrinol. 45: 457–468 (1977).Google Scholar
  11. 11.
    J. Lemann jr„ W.J. Maierhofer, N.D. Adams, and R.W. Gray, Increased serum 1,25(OH)2D3 con-centrations fails to affect serum or urine posphate in humans, in: Regulation of phosphate and mineral, S.G. Massry, J.M. Letteri and E. Ritz (eds.) Plenum, New York and London (1982).Google Scholar
  12. 12.
    J.-P. Bonjour, U. Tröhler, R. Mühlbauer, C. Preston and H. Fleisch, Is there a bone-kidney link in the homeostasis of inorganic phosphate (Pi)? in: Phosphate Metabolism (Vol. 81 in Advances in Experimental Medicine and Biology). Proc. 2nd International Workshop on Phosphate, Heidelberg, 1976. S.G. Massry and E. Ritz, eds. Plenum Press, New York–London, (1977), pp. 319–322.Google Scholar
  13. 13.
    J.-P. Bonjour, J. Caverzasio, R. Mühlbauer, H. Fleisch, and U. Trechsel, Acute and chronic effects of vitamin D metabolites on the renal handling of phosphate, in: Vitamin D, Basic Research and its Clinical Application, A.W. Norman, K. Schaefer, D. v. Herrath, H.-G. Grigoleit, J.W. Coburn, H.F. DeLuca, E.B. Mawer and T. Suda, eds. W. de Gruyter, Berlin (1979), pp. 307–314.Google Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Ulrich Troehler
    • 1
  • Jean-Philippe Bonjour
    • 1
    • 2
  • Herbert Fleisch
    • 1
  1. 1.Department of PathophysiologyUniversity of BernBernSwitzerland
  2. 2.Division of Pathophysiology, Dept. of MedicineHôpital cantonalGeneva 4Switzerland

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