Glucocorticoid-Induced Inhibition of the Reabsorption of Inorganic Phosphate in the Proximal Tubule in the Absence of Parathyroid Hormone

  • Anselm Frick
  • Ivan Durasin
  • Mechtild Neuweg
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 178)


Roberts and Pitts (1) demonstrated a reduction of the maximal reabsorptive capacity for inorganic phosphate (Tmpi) due to cortisone administration in dogs. For different reasons we reexamined this effect in the rat (2) and confirmed the former observation both in the presence and the absence of parathyroid hormone. In order to localize this glucocorticoid effect in the nephron we employed the micropuncture techniques. Our results from proximal convolutions together with the data from the whole kidney suggest an important proximal locus of action of hydrocortisone in the Pi-transport.


Proximal Tubule Glucocorticoid Effect Renal Brush Border Membrane Single Nephron Glomerular Filtration Rate Proximal Tubular Reabsorption 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    K. E. Roberts and R. F. Pitts. The effects of cortisone and desoxycorticosterone on the renal tubular reabsorption of phosphate and the excretion of titrable acid and potassium in dogs. Endocrinology 52: 324–330 (1953)PubMedCrossRefGoogle Scholar
  2. 2.
    A. Frick, I. Durasin, and M. Neuweg. Phosphaturic response of hydrocortisone in the presence and the absence of parathyroid hormone. Pflügers Arch. 392: 99–105 (1981)PubMedCrossRefGoogle Scholar
  3. 3.
    G. Peters. Der Einfluß von Nebennierenrindenhormonen auf die renale Wasser-und Elektrolytausscheidung bei adrenalektomierten und normalen Ratten nach Gabe von Wasser oder isotonischer NaCl-Lösung und im Durst. Naunyn-Schmiedeberg’s Arch.exp.Path.u.Pharmak. 235: 155–184 (1959)Google Scholar
  4. 4.
    M. Wiederholt, H. Stolte, J. P. Brecht, and K. Hierholzer. Mikropunktionsuntersuchungen über den Einfluß von Aldosteron, Cortison und Dexamethason auf die renale Natriumresorption adrenalektomierter Ratten. Pflügers Arch. 292: 316–333 (1966)CrossRefGoogle Scholar
  5. 5.
    H. Wirz. Der osmotische Druck in den cortikalen Tubuli der Rattenniere. Helv.Physiol.Pharmacol.Acta 14: 353 (1956)PubMedGoogle Scholar
  6. 6.
    A. Frick. Proximal tubular reabsorption of inorganic phosphate during saline infusion in the rat. Am.J.Physiol. 223: 1034–1040 (1972)PubMedGoogle Scholar
  7. 7.
    A. Frick and I. Durasin. Proximal tubular reabsorption of inorganic phosphate in adrenalectomized rats. Pflügers Arch. 385: 189–192 (1980)PubMedCrossRefGoogle Scholar
  8. 8.
    M. Steinhausen. Eine Methode zur Differenzierung proximaler und distaler Tubuli der Nierenrinde von Ratten in vivo und ihre Anwendung zur Bestimmung tubulärer Strömungsgeschwindigkeiten. Arch.Ges.Physiol. 277: 23–35 (1963)CrossRefGoogle Scholar
  9. 9.
    K. H. Gertz, J. A. Mangos, G. Braun, and H. D. Pagel. On the glomerular tubular balance in the rat kidney. Arch.Ges. Physiol. 285: 360–372 (1965)Google Scholar
  10. 10.
    H. H. Hilger, J. D. Klümper, and K. J. Ullrich. Wasserrückresorption und Ionentransport durch die Sammelrohrzellen der Sâugetierniere. Arch.Ges.Physiol. 267: 218–237 (1958)CrossRefGoogle Scholar
  11. 11.
    P. S. Chen, Jr., T. Y. Toribara, and H. Warner. Microdetermination of phosphorus. Anal.Chem. 28: 1756–1758 (1956)CrossRefGoogle Scholar
  12. 12.
    T. Mishina, D. W. Scholer, and I. S. Edelman. Glucocorticoid receptors in rat kidney cortical tubules enriched in proximal and distal segments. Am.J.Physiol. 240: 38–45 (1981)Google Scholar
  13. 13.
    J. M. Freiberg, J. Kiesella, and B. Sacktor. Glucosorticoids increase the Na -H exchange and decrease the Na gradient-dependent phosphate-uptake systems in renal brush border membrane vesicles. Proc.Natl.Acad.Sci.USA 79: 4932–4936 (1982)PubMedCrossRefGoogle Scholar
  14. 14.
    S. T. Turner, G. M. Kiebzak, and T. P. Dousa. Mechanism of glucocorticoid effect on renal transport of phosphate. Am.J.Physiol. 243: C227–C236 (1982)PubMedGoogle Scholar
  15. 15.
    N. Hoffmann, M. Thees, and R. Kinne. Phosphate transport by isolated renal brush border vesicles. Pflügers Arch. 362: 147–156 (1976)PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Anselm Frick
    • 1
  • Ivan Durasin
    • 1
  • Mechtild Neuweg
    • 1
  1. 1.Department of PhysiologyUniversity of MunichMunichFederal Republic of Germany

Personalised recommendations