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Glucocorticoid-Induced Inhibition of the Reabsorption of Inorganic Phosphate in the Proximal Tubule in the Absence of Parathyroid Hormone

  • Anselm Frick
  • Ivan Durasin
  • Mechtild Neuweg
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 178)

Abstract

Roberts and Pitts (1) demonstrated a reduction of the maximal reabsorptive capacity for inorganic phosphate (Tmpi) due to cortisone administration in dogs. For different reasons we reexamined this effect in the rat (2) and confirmed the former observation both in the presence and the absence of parathyroid hormone. In order to localize this glucocorticoid effect in the nephron we employed the micropuncture techniques. Our results from proximal convolutions together with the data from the whole kidney suggest an important proximal locus of action of hydrocortisone in the Pi-transport.

Keywords

Proximal Tubule Glucocorticoid Effect Renal Brush Border Membrane Single Nephron Glomerular Filtration Rate Proximal Tubular Reabsorption 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Anselm Frick
    • 1
  • Ivan Durasin
    • 1
  • Mechtild Neuweg
    • 1
  1. 1.Department of PhysiologyUniversity of MunichMunichFederal Republic of Germany

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