Calcium (Ca) Mediated Phosphate (PO4) Transport in the Proximal Convoluted Tubule (PCT) of the Rabbit

  • Diane Rouse
  • Wadi N. Suki
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 178)


Several clearance studies have suggested a direct effect of calcium (Ca) on phosphate (PO4) handling by the kidney. Micropuncture studies by Amiel and colleagues1 have shown enhancement of fractional phosphate reabsorption in the proximal convoluted tubule when plasma calcium was raised from low towards normal values in parathyroidectomized rats. Conversely, Goldfarb et al 2 have shown a decline in fractional phosphate reabsorption in this portion of the nephron with the induction of mild hypercalcemia in thyroparathyroidectomized dogs. The divergence of these results may be due to species differences, the level of plasma phosphate or ionized calcium before and after calcium chloride administration, or the other various indirect effects of calcium on phosphate handling by the nephron.


Proximal Convoluted Tubule Tubule Segment Phosphate Reabsorption Plasma Phosphate Micropuncture Study 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    C. Amiel, H. Kuntziger, S. Couette, C. Coureau, and N. Bergounioux, Evidence for a parathyroid hormone-induced calcium modulation of phosphate transport along the nephron, J. Clin. Invest. 57: 256 (1976).PubMedCrossRefGoogle Scholar
  2. 2.
    S. Goldfarb, P. Bosanac, M. Goldberg, and Z.S. Agus, Effects of calcium on renal tubular phosphate reabsorption, Am. J. Physiol. 234 (1): F22 (1978).PubMedGoogle Scholar
  3. 3.
    M. Burg, J. Grantham, M. Abramow, and J. Orloff, Preparation and study of fragments of single rabbit nephrons. Am. J. Physiol. 210: 1293 (1966).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Diane Rouse
    • 1
  • Wadi N. Suki
    • 1
  1. 1.Baylor College of Medicine and The Methodist HospitalHoustonUSA

Personalised recommendations