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Comparison of the Effect of Nucleotides on Phosphate Transport in Renal Brush Border Membrane Vesicles and Intact Proximal Tubules

  • Leon G. Fine
  • Ronald Lang
  • Edward P. Nord
  • Norimoto Yanagawa
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 178)

Abstract

It has been proposed that nicotinamide adenine dinucleotide (NAD) may be an important regulator of sodium-dependent phosphate (P) transport across the proximal tubular brush border membrane (BBM). NAD appears to cause inhibition of P uptake by BBM vesicles in vitro, and the in vivo administration of nicotinamide leads to phosphaturia1. The NAD effect on P-transport has been linked to ADP-ribosylation of the BBM2.

Keywords

Proximal Tubule Brush Border Membrane Nicotinamide Adenine Dinucleotide Phosphate Transport Renal Brush Border Membrane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    SA Kempson, G Colon-Otero, S-YL Ou, ST Turner, and T Dousa. Possible role of nicotinamide adenine dinucleotide as an intracellular regulator of renal transport of phosphate in the rat. J Clin Invest. 67: 1347–1360 (1981).PubMedCrossRefGoogle Scholar
  2. 2.
    MR Hammerman, VA Hansen, and JJ Morrisey. ADP-ribosylation of canine renal brush border membrane vesicle protein is associated with decreased phosphate transport. J Biol Chem. 257: 1238012386 (1982).Google Scholar
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    RP Lang, N Yanagawa, EP Nord, L Sakhrani, S Lee, and LG Fine. Nucleotide inhibition of phosphate transport in the renal proximal tubule. Am J Physiol. In Press (1983).Google Scholar
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    HS Tenenhouse and YL Chu. Hydrolysis of nicotinamide-adenine dinucleotide by purified renal brush border membranes. Biochem J. 204: 635–638 (1982).PubMedGoogle Scholar
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    SG George and AJ Kenny. Studies on the enzymology of purified preparations of brush border from rabbit kidney. Biochem J. 134: 43–57 (1973).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Leon G. Fine
    • 1
    • 2
  • Ronald Lang
    • 1
    • 2
  • Edward P. Nord
    • 1
    • 2
  • Norimoto Yanagawa
    • 1
    • 2
  1. 1.Divisions of NephrologyUCLA Center for the Health SciencesLos AngelesUSA
  2. 2.Sepulveda Veterans Administration HospitalUniversity of California, Los Angeles School of MedicineLos AngelesUSA

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