Comparison of the Effect of Nucleotides on Phosphate Transport in Renal Brush Border Membrane Vesicles and Intact Proximal Tubules
It has been proposed that nicotinamide adenine dinucleotide (NAD) may be an important regulator of sodium-dependent phosphate (P) transport across the proximal tubular brush border membrane (BBM). NAD appears to cause inhibition of P uptake by BBM vesicles in vitro, and the in vivo administration of nicotinamide leads to phosphaturia1. The NAD effect on P-transport has been linked to ADP-ribosylation of the BBM2.
KeywordsProximal Tubule Brush Border Membrane Nicotinamide Adenine Dinucleotide Phosphate Transport Renal Brush Border Membrane
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