Factors Regulating Ligand Binding to 5-Hydroxytryptamine Receptors in Rat Brain

  • Tomio Segawa
  • Yasuyuki Nomura
  • Hiroaki Nishio
  • Jun-ichi Taguchi
  • Mutsuko Fujita
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 160)


Several factors have been known to regulate neurotransmitter receptor binding to central nervous system (CNS) but so far little is known about the factors which modify 5-hydroxytryptamine (5-HT) binding properties. Recently, in the course of 5-HT binding studies, it was found that ascorbic acid (AA), Mn2+, and HCO 3 could modify ligand binding to central 5-HT receptors in rat.


Ascorbic Acid Adenylate Cyclase Guanine Nucleotide Iodoacetic Acid Lysergic Acid Diethylamide 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Tomio Segawa
    • 1
  • Yasuyuki Nomura
    • 1
  • Hiroaki Nishio
    • 1
  • Jun-ichi Taguchi
    • 1
  • Mutsuko Fujita
    • 1
  1. 1.Department of Pharmacology, Institute of Pharmaceutical SciencesHiroshima University School of MedicineHiroshimaJapan

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