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Reconstitution of the Regulatory Functions of β-Adrenergic Receptors

  • Elliott M. Ross
  • Tomiko Asano
  • Steen E. Pedersen
  • Douglas R. Brandt
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 160)

Abstract

The hormone-sensitive adenylate cyclase system acts as the intracellular effector for numerous neurotransmitters and hormones whose receptors are located on the cell surface. Multiple inhibitory and stimulatory receptors with specificities for different ligands can act simultaneously on a single target cell to modulate the activity of adenylate cyclase on the inner face of the plasma membrane. In addition to acute control, several different mechanisms exist for the long-term regulation of the enzyme, of individual receptors, and of the coupling process. Inhibitory control of adenylate cyclase is discussed by Drs. Ui and Aktories in this volume, and Harden (1) has thoroughly reviewed refractoriness and other modes of chronic regulation of adenylate cyclase recently. Here, we will discuss the biochemical events that couple transmitter binding to its receptor with the stimulation of adenylate cyclase.

Keywords

Adenylate Cyclase Guanine Nucleotide Adenylate Cyclase Activity GTPase Activity Phospholipid Vesicle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Elliott M. Ross
    • 1
  • Tomiko Asano
    • 1
  • Steen E. Pedersen
    • 1
  • Douglas R. Brandt
    • 1
  1. 1.Department of PharmacologyUniversity of Texas Health Science Center at DallasDallasUSA

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