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Role of Hormone-Sensitive GTPases in Adenylate Cylase Regulation

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Neurotransmitter Receptors

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 175))

Abstract

A large variety of hormones and neurotransmitters transmit their regulatory signals into target cells via stimulation or inhibition of adenylate cyclase and the consequent increase or decrease of intracellular cyclic AMP levels. Because of the importance of adenylate cyclase as a signal transduction system, interest in adenylate cyclase has centered on the mechanisms and components involved in its hormonal control. The complete transduction system is composed of at least the specific stimulatory and inhibitory hormone receptors, the adenylate cyclase itself and two guanine nucleotide-binding, regulatory components, Ns and Ni, which act as coupler between stimulatory and inhibitory hormone receptors, respectively, and adenylate cyclase (1,2). Both types of hormones, adenylate cyclase stimulatory and inhibitory, have been shown to stimulate GTPase(s) in membrane preparations. In this review, the role of this hormone-stimulated GTP hydrolysis in the bidirectional regulation of adenylate cyclase will be considered.

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Author information

Authors and Affiliations

  1. Pharmakologisches Institut der Universität Heidelberg, Im Neuenheimer Feld 366, D-6900, Heidelberg, Federal Republic of Germany

    Klaus Aktories, Günter Schultz & Karl H. Jakobs

Authors
  1. Klaus Aktories
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  2. Günter Schultz
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  3. Karl H. Jakobs
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Editor information

Editors and Affiliations

  1. Third Department of Internal Medicine, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minamiku, Hiroshima 734, Japan

    Shozo Kito M.D., Ph.D.

  2. Department of Pharmacology Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minamiku, Hiroshima 734, Japan

    Tomio Segawa Ph.D.

  3. Department of Pharmacology, Kyoto Prefectural University of Medicine, Kawaramachi, Hirokoji, Kamikyoku Kyoto 602, Japan

    Kinya Kuriyama M.D.

  4. Departments of Pharmacology, Biochemistry, Psychiatry and the Arizona Research Laboratories, University of Arizona Health Sciences Center, 85724, Tucson, Arizona, USA

    Henry I. Yamamura Ph.D.

  5. Department of Pharmacology, University of California, Los Angeles School of Medicine, 90024, Los Angeles, California, USA

    Richard W. Olsen Ph.D.

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© 1984 Plenum Press, New York

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Aktories, K., Schultz, G., Jakobs, K.H. (1984). Role of Hormone-Sensitive GTPases in Adenylate Cylase Regulation. In: Kito, S., Segawa, T., Kuriyama, K., Yamamura, H.I., Olsen, R.W. (eds) Neurotransmitter Receptors. Advances in Experimental Medicine and Biology, vol 175. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-4805-4_3

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  • DOI: https://doi.org/10.1007/978-1-4684-4805-4_3

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