Structure and Properties of the Brain GABA/Benzodiazepine Receptor Complex
Two classes of receptor for γ-aminobutyrate (GABA) in the brain have been clearly defined, although there are hints of the existence of others. The first is the GABA-A receptor, at which benzodiazepines potentiate the electrophysiological activity of GABA, bicuculline is a strong antagonist and muscimol, isoguvacine and certain other ligands are strong agonists. The second is the GABA-B receptor (1) which has none of the properties just mentioned but which, in contrast to the GABA-A receptor, requires Ca2+ for the binding of GABA and has baclofen as a characteristic agonist. The GABA-A receptor, exclusively, will be dealt with here.
KeywordsReceptor Complex Xenopus Oocyte Gaba Receptor Scatchard Plot Gaba Agonist
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