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Biochemical Properties of the GABA/Barbiturate/Benzodiazepine Receptor-Chloride Ion Channel Complex

  • R. W. Olsen
  • E. H. F. Wong
  • G. B. Stauber
  • D. Murakami
  • R. G. King
  • J. B. Fischer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 160)

Abstract

The inhibitory neurotransmitter γ-aminobutyric acid (GABA) acts by increasing chloride permeability in the postsynaptic cell membrane. Chloride ion channels are regulated via GABA binding to its receptor. The cellular response to GABA has been shown to be enhanced by benzodiazepine and barbiturate drugs. This potentiation of GABA-mediated inhibition may explain much of the nervous system depressant action of these clinically important agents.

Keywords

Gaba Receptor Allosteric Interaction Gaba Binding Diazepam Binding Bicuculline Methiodide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • R. W. Olsen
    • 1
    • 2
  • E. H. F. Wong
    • 1
    • 2
  • G. B. Stauber
    • 1
    • 2
  • D. Murakami
    • 1
    • 2
  • R. G. King
    • 1
    • 2
  • J. B. Fischer
    • 1
    • 2
  1. 1.Department of Biochemistry and Division of Biomedical SciencesUniversity of CaliforniaRiversideUSA
  2. 2.Department of PharmacologyUCLA School of MedicineLos AngelesUSA

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