Ontogenetic Development of the Specific [3H]Nitrendipine Binding Sites in the Rat Whole Brain

  • H. Matsubayashi
  • S. Kito
  • E. Itoga
  • K. Mizuno
  • R. Miyoshi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 160)


Ca ion channel antagonists have been attracting much attention as therapeutic drugs for cardiovascular disorders such as angina pectoris and hypertension, especially from the viewpoint of pharmacological mechanism. Recently, through Ehlert and Itoga’s experiments, the Ca ion channel antagonist was confirmed to bind specifically, not only to vascular smooth muscle but also to gastrointestinal smooth muscle and even to the neuron itself (1). This broke new ground in the study of the pharmacological action of Ca ion channel antagonists.


Olfactory Bulb Superior Colliculus Subcellular Fraction Ontogenetic Development Postnatal Stage 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • H. Matsubayashi
    • 1
  • S. Kito
    • 1
  • E. Itoga
    • 1
  • K. Mizuno
    • 1
  • R. Miyoshi
    • 1
  1. 1.Third Department of Internal MedicineHiroshima University School of MedicineHoroshima 734Japan

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