Modulation of Neuroreceptor Functions by Lipomodulin, a Phospholipase Inhibitory Protein
Glucocorticoids are hormones from the adrenal cortex. Secretion of these hormones is controlled by ACTH from the pituitary gland. The regulation of glucocorticoid secretion by ACTH is influenced by a variety of factors, including stress and depression. Therapeutically, glucocorticoids are often used to treat patients with chronic inflammation and immunological diseases, such as systemic lupus erythematosus and rheumatoid arthritis. Antiinflammatory action of glucocorticoids is now proposed to be associated with the induction of synthesis of phospholipase inhibitory proteins, macrocotin in macrophages (1), renocortin in kidney cells (2) and lipomodulin in neutrophils (3). All these proteins are immunologically and biologically related (4). We isolated this protein from neutrophils treated with glucocorticoids and examined its effects on receptor functions and on neural development. We found that lipomodulin can regulate functions of certain types of receptors and differentiate neuronal cells to the adrenergic phenotype.
KeywordsSystemic Lupus Erythematosus Arachidonic Acid Receptor Function Antibody Dependent Cellular Cytotoxicity Arachidonic Acid Release
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