Ca2+-Activated, Fatty Acid-Dependent Guanylate Cyclase in Synaptic Plasma Membranes and Its Requirement for Ca2+ and Mg-GTP in the Activation

  • Takeo Asakawa
  • Masako Takano
  • Keiichi Enomoto
  • Kazuko Hayama
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 160)

Abstract

Cyclic GMP in an intact cell system was reported to increase by various biologically active compounds, including muscarinic cholinergic agonists and excitatory amino acids, and supposed to act as intracellular messenger of the various neurotransmitters and hormones. Guanylate cyclase, a cyclic GMP-generating enzyme, in a cell free system can not be stimulated by agents increasing cyclic GMP contents. This suggests that the cyclase is activated by a substance generated or a process taking place within cells upon hormone stimulation. Thus cellular components such as Ca2+, fatty acids and their metabolites that are intracellularly liberated on the stimulation have been supposed to be possible physiological activators of guanylate cyclase in intact cells.

Keywords

Histamine Indomethacin Hydroperoxide Guanine Pertussis 

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Takeo Asakawa
    • 1
  • Masako Takano
    • 1
  • Keiichi Enomoto
    • 1
  • Kazuko Hayama
    • 1
  1. 1.Department of PharmacologySaga Medical School NabeshimaNabeshima-machi, SagaJapan

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