Macromolecular Factors Involved in the Regulation of the Survival and Differentiation of Neurons During Development

  • Hans Thoenen
Part of the NATO ASI Series book series (NSSA, volume 78)


It is a well-established, almost universal phenomenon that, during the ontogenesis of the peripheral and central nervous systems of vertebrates, neurons are initially produced in excess and that the subsequent selective neuronal death occurs as a normal event (Cowan, 1973; Jacobson, 1978). The topographically selective regulation of survival is an important mechanism for the formation of the final structure and function of integrated neuronal systems. The possible mechanism(s) involved in the regulation of neuronal survival have mainly been investigated in the peripheral nervous system, which is relatively simply organized, both structurally and functionally, and which is therefore better suited for detailed analysis than the more complex central nervous system.


Nerve Growth Factor Conditioned Medium Tyrosine Hydroxylase Sensory Neuron Survival Factor 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Hans Thoenen
    • 1
  1. 1.Department of NeurochemistryMax-Planck-Institute for PsychiatryFederal Republic of Germany

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