The Sprouting and Distribution of Sensory Nerve Endings

  • Jack Diamond
Part of the NATO ASI Series book series (NSSA, volume 78)


The innervation of skin provides an instructive system for revealing some of the mechanisms that regulate the sprouting and distribution of axonal endings at target tissues.


Nerve Growth Factor Dorsal Root Ganglion Target Tissue Carotid Body Glomus Cell 
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  1. Aguilar, C.E., Bisby, M.A., Cooper, E. and Diamond, J., 1973, Evidence that axoplasmic transport of trophic factors is involved in the regulation of peripheral nerve fields in salamanders, J. Physiol., 234:449–464.Google Scholar
  2. Blackshaw, S.E., Nicholls, J.G., and Parnas, I., 1982, Expanded receptive fields of cutaneous mechanoreceptor cells after single neurone deletion in leech central nervous system, J. Physiol. (Lond), 326:261–268.Google Scholar
  3. Call, T.W. and Bell, M., 1979, Ultrastructural features of Merkel cells during murine ontogenetic differentiation, Anat. Rec., 193:495.Google Scholar
  4. Cass, D.T., Sutton, T.J. and Mark, R.F., 1973, Competition between nerves for functional connexions with Axolotl muscle, Nature, 243:201–203.CrossRefGoogle Scholar
  5. Cooper, E., and Diamond, J., 1977, A quantitative study of the mechanosensory innervation of salamander skin, J. Physiol., 264:695–723.Google Scholar
  6. Cooper, E., Diamond, J., and Turner, C., 1977, The effects of nerve section and of colchicine treatment on the density of mechanosensory nerve endings in salamander skin, J. Physiol. (Lond.), 264:725–759.Google Scholar
  7. Devor, M., Schonfield, D., Seltzer, Z., and Wall, P.D., 1979, Two modes of cutaneous reinnervation following peripheral nerve injury, J. Comp. Neurol., 185:211–220.CrossRefGoogle Scholar
  8. Diamond, J., 1979, The regulation of nerve sprouting by extrinsic influences, in: The Neurosciences Fourth StudyProgram, (F.O. Schmitt and F.G. Worden, editors-in-chief), M.I.T. Press, Cambridge, Mass., pp. 937–955.Google Scholar
  9. Diamond, J., 1981, The recovery of sensory function in skin after peripheral nerve lesions, in: Post-Traumatic Peripheral Nerve Regeneration: Experimental Basis and Clinical Implications, (A. Gorio et al., eds.), Raven Press, N.Y., pp. 533–548.Google Scholar
  10. Diamond, J., 1982a, Modelling and competition in the nervous system: clues from the sensory innervation of skin, Curr. Top. Dev. Biol., 17:147–205.CrossRefGoogle Scholar
  11. Diamond, J., 1982b, The patterning of neuronal connections, Amer. Zool., 22:153–172.Google Scholar
  12. Diamond, J., Cooper, E., Turner, C. and Macintyre, L., 1976, Trophic regulation of nerve sprouting, Science, 193:371–377.CrossRefGoogle Scholar
  13. Diamond, J., Macintyre, L., Nurse, C.A., and Visheau, B., in press, Modelling and remodelling within a cutaneous mechanosensory structure in rats, J. Physiol., (abstr.).Google Scholar
  14. Ebendal, T., Olson, L., Seiger, A., and Hedlund, O., 1980, Nerve growth factors in the rat iris, Nature, 286:25–28.CrossRefGoogle Scholar
  15. Fitzgerald, M.J.T., Folan, J.C., and O’Brien, T.M., 1975, The innervation of hyperplastic epidermis in the mouse: a light microscopic study, J. Invest. Dermatol., 64:169–174.CrossRefGoogle Scholar
  16. Gottleib, D.I., and Glasser, L., 1980, Cellular recognition during neural development, Ann. Rev. Neurosci., 3:303–318.CrossRefGoogle Scholar
  17. Gorin, P.D. and Johnson, E.M., 1980, Effects of long-term nerve growth factor deprivation on the nervous system of the adult rat: an experimental autoimmune approach, Brain Res., 198:27–42.CrossRefGoogle Scholar
  18. Hashimoto, K., 1972, The ultrastructure of the skin in human embryos, J. Anat., 111:99–120.Google Scholar
  19. Henderson, W.R., 1948, Clinical assessment of peripheral nerve injury. Tinel’s test, Lancet, 2:801.CrossRefGoogle Scholar
  20. Hnik, P., and Payne, R., 1965, Spontaneous activity in nonproprio-ceptive sensory fibres from de-efferented muscles, J. Physiol., 180:25–26P.Google Scholar
  21. Jackson, P.C., and Diamond, J., 1981, Regenerating axons reclaim sensory targets from collateral nerve sprouts, Science, 214:926–928.CrossRefGoogle Scholar
  22. Johnson, E.M., Gorin, P.D., Brandeis, L.D., and Pearson, J., 1980, Dorsal root ganglion neurons are destroyed by exposure in utero to maternal antibody to nerve growth factor, Science, 210:916–918.CrossRefGoogle Scholar
  23. Levi-Montalcini, jR., and Angeletti, P.A., 1968, Nerve growth factor, Physiol. Rev., 48:534–569.Google Scholar
  24. Lyne, A.G., and Hollis, D.E., 1971, Merkel cells in sheep during fetal development, J. Ultrastruc. Res., 34:464–472.CrossRefGoogle Scholar
  25. Macintyre, L., and Diamond, J., 1981, Domains and mechanosensory nerve fields in salamander skin, Proc. Roy. Soc. Lond. B., 211:471–499.CrossRefGoogle Scholar
  26. McDonald, D.M., 1981, Peripheral chemoreceptors: structure-function relationships of the carotid body, in: Regulation of Breathing. Part I, (Hornbein, T.F., Ed.) Marcel Deker, Inc., N.Y., pp. 105–317.Google Scholar
  27. Mearow, K.M., Nurse, C.A., Visheau, B., and Diamond, J., 1981, Interactions between co-cultured amphibian sensory neurons and mechanosensory target tissues, Soc. for Neurosci. Abstr., 7:547.Google Scholar
  28. Monti-Bloch, L., Stensaas, L.J., and Ezyaguirre, C., 1981, Induction of chemosensitivity in a muscle nerve after grafting the carotid body into the muscle, Soc. for Neurosci. Abstr., 7:469.Google Scholar
  29. Nurse, C.A., Mearow, K.M., Vishea, B., Holmes, M., and Diamond, J., 1981, Comparison of the distribution of mechanosensory target (Merkel) cells in mammalian and amphibian epidermis using guinacrine fluorescence as a marker, Soc. for Neurosci. Abstr. 7:417.Google Scholar
  30. Nurse, C.A., Macintyre, L., and Diamond, J., 1982, Effect of sensory denervation on the postnatal development of Merkel cells within the rat touch dome, Soc. for Neurosci. Abstr., 8:756.Google Scholar
  31. Nurse, C.A., Mearow, K.M., Holmes, M., Visheau, B., and Diamond, J., (in press), Merkel cell distribution in various tissues using guinacrine fluorescence as a marker, Cell and Tiss. Res. Google Scholar
  32. Ramony Cajal, S., 1919, Studies on Vertebrate Neurogenesis, L. Guth trans., Charles C. Thomas (1960), Springfield, Ill.Google Scholar
  33. Saxod, R., 1978, Avian mechanoreceptive corpuscles, in: Handbook of Sensory Physiology, Vol. 9, (M. Jacobson, Ed.), Springer-Verlag, N.Y., pp. 337–417.Google Scholar
  34. Scott, S.A., Cooper, E., and Diamond, J., 1981a, Merkel cells as targets of the mechanosensory nerves in salamander skin, Proc. Roy. Soc. Lond. B., 211:455–470.CrossRefGoogle Scholar
  35. Scott, S.A., Macintyre, L.A., and Diamond, J., 1981b, Competitive reinnervation of salamander skin by regenerating and intact mechanosensory nerves, Proc. Roy. Soc. Lond. B., 211:501–511.CrossRefGoogle Scholar
  36. Tweedle, C.D., 1978, Ultrastructure of Merkel cell development in aneurogenic and control Amphibian larvae (Ambystoma), Neuroscience, 3:481–486.CrossRefGoogle Scholar
  37. Wigston, D.J., 1980, Suppression of sprouted synapses in axolotl muscle by transplanted foreign nerves, J. Physiol., 307:355–366.Google Scholar
  38. Zelena, J., 1980, Rapid degeneration and regeneration of receptor organs, Brain Res., 187:97–111.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Jack Diamond
    • 1
  1. 1.Department of NeurosciencesMcMaster UniversityHamiltonCanada

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