Cellular Interactions and the Survival and Maintenance of Neurons During Development

  • Ronald W. Oppenheim
Part of the NATO ASI Series book series (NSSA, volume 78)


Perhaps the most fundamental organizing principle of the developing nervous system is the role of cell and tissue interactions in regulating the countless steps leading from the zygote to the adult. Virtually nothing in the entire field of neuroembryology makes much sense if viewed from a perspective that is devoid of an appreciation of the pervasiveness of cell-to-cell inter-relationships. Starting with the origins of the nervous system during primary induction and continuing up to the final stages of neurobehavioral development no stage or event in neurogenesis is ever entirely independent of the influence of cellular interactions.


Nerve Growth Factor Neuronal Death Chick Embryo Neuromuscular Blockade Spinal Motoneuron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Ashmore, C.R., Addies, P.B., Doerr, L. and Stokes, M., 1973, Development of muscle fibers in the complexus muscle of normal and dystrophic chicks, J. Histochem. Cytochem. 21:266–278.CrossRefGoogle Scholar
  2. Ashmore, C.R., Kikuchi, T. and Doerr, L., 1978, Some observations on the innervation pattern of different fiber types of chick muscles, Exp. Neurol. 58:272–284.CrossRefGoogle Scholar
  3. Ashmore, C.R., Robinson, D.W., Rattray, P. and Doerr, L., 1972, Biphasic development of muscle fibers in the fetal lamb, Exp. Neurol. 37:241–255.CrossRefGoogle Scholar
  4. Atsumi, S., 1977, Development of neuromuscular junctions of fast and slow muscles in the chick embryo: a light and electron microscopic study, J. Neurocytol. 6:691–709.CrossRefGoogle Scholar
  5. Atsumi, S., 1981, Localization of surface and internal acetylcholine receptors in developing fast and slow muscles of the chick embryo, Dev. Biol. 86:122–135.CrossRefGoogle Scholar
  6. Bennett, M.R., Lai, K. and Nurcombe, V., 1980, Identification of embryonic motoneurons in vitro: their survival is dependent on skeletal muscle, Brain Res. 190:537–542.CrossRefGoogle Scholar
  7. Bennett, M.R. and Pettigrew, A., 1974, The formation of synapses in striated muscle during development, J. Physiol. 241:515–545.Google Scholar
  8. Bennett, M.R. and Lavidis, N.A., 1982, Development of the topographical projection of motor neurons to amphibian muscles accompanies motor neuron death, Dev. Brain Res. 2:448–452.CrossRefGoogle Scholar
  9. Betz, H., Bourgeois, J.P. and Changeux, J.P., 1980, Evolution of cholinergic proteins in developing slow and fast muscles in chick embryos, J. Physiol. 302:197–218.Google Scholar
  10. Bibb, H.D., 1978, Neuronal death in the development of normal and hyperplastic spinal ganglia, J. Exp. Zool., 206:65–72.CrossRefGoogle Scholar
  11. Blackshaw, S.E. and Warner, A., 1976, Onset of acetylcholine sensitivity and endplate activity in developing myotome muscles of Xenopus, Nature 262:217–218.CrossRefGoogle Scholar
  12. Bostwick, J.R. and Appel, S.J., 1981, Effects of brain extracts on the number of acetylcholine receptors in primary cultures of rat myotubes, Soc. Neurosci. Abstract 7:553.Google Scholar
  13. Breakfield, X.O., Altered nerve growth factor in familial dysautonomia: discovering the molecular basis of an inherited neurologic disease, Neurosci. Comm. 1:28–32.Google Scholar
  14. Burden, S.J., 1977, Development of the neuromuscular junction in the chick embryo: the number, distribution and stability of acetylcholine receptors, Dev. Biol. 57:317–329.CrossRefGoogle Scholar
  15. Burden, S.J., Sargent, P.B. and McMahan, U.J., 1979, Acetylcholine receptors in regenerating muscle accumulate at original synaptic sites in the absence of the nerve, J. Cell Biol. 82:412–425.CrossRefGoogle Scholar
  16. Burke, R.E., Strick, P.L., Kanda, C. and Walmsley, B., 1977, Anatomy of medial gastrocnemius and soleus motor nuclei in cat spinal cord, J. NeuroPhysiol. 40:667–680.Google Scholar
  17. Butler, J. and Cosmos, E., 1981, Differentiation of the avian latissimus dorsi primordium: analysis of fiber type expression using the myosin ATPase histochemical reaction, J. Exp. Zool. 218:219–232.CrossRefGoogle Scholar
  18. Carraro, U., Libera, L.D. and Catani, C., 1981, Myosin light chains of avian and mammalian slow muscles: evidence of intraspecific polymorphism, J. Muscle Res. Cell Motility 2:335–342.CrossRefGoogle Scholar
  19. Chan, K.Y. and Haschke, R.H., 1981, Action of a trophic factor(s) from rabbit corneal epithelial culture on dissociated trigeminal neurons, J. Neurosci. 1:1155–1162.Google Scholar
  20. Christian, C.N., Daniels, M.P., Sugiyama, H., Vogel, Z., Jagues, J. and Nelson, P.G., 1978, A factor from neurons increases the number of acetylcholine receptor aggregates on cultured muscle cells, Proc. Natl. Acad. Sci. USA. 75:4011–4015.CrossRefGoogle Scholar
  21. Chu-Wang, I.-W. and Oppenheim, R.W., 1978a, Cell death of motoneurons in the chick embryo spinal cord. I. A light and electron microscopic study of naturally-occurring and induced cell loss during development, J. Comp. Neurol. 177:33–58.CrossRefGoogle Scholar
  22. Chu-Wang, I.-W. and Oppenheim, R.W., 1978b, Cell death of motoneurons in the chick embryo spinal cord. II. A guantitative and guali-tative analysis of degeneration in the ventral root, including evidence for axon outgrowth and limb innervation prior to cell death, J. Comp. Neurol. 177:59–86.CrossRefGoogle Scholar
  23. Clarke, P.G.H. and Cowan, W.M., 1976, The development of the isthmooptic tract in the chick, with special reference to the occurrence and correction of developmental errors in the location and connection of isthmo-optic neurons, J. Comp. Neurol. 167:143–163.CrossRefGoogle Scholar
  24. Clarke, P.G.H., Rogers, L.A. and Cowan, W.M., 1976, The time of origin and the pattern of survival of neurons in the isthmo-optic nucleus of the chick, J. Comp. Neurol. 167:125–141.CrossRefGoogle Scholar
  25. Cohen, S.A., 1980, Early nerve-muscle synapses in vitro release transmitter over postsynaptic membrane having low acetylcholine sensitivity, Proc. Natl. Acad. Sci., USA 77:644–648.CrossRefGoogle Scholar
  26. Cohen, M.W. and Weldon, P.R., 1980, Localization of acetylcholine receptors and synaptic ultrastructure at nerve-muscle contacts in culture: dependence on nerve type, J. Cell. Biol. 86:388–401.CrossRefGoogle Scholar
  27. Coughlin, M.D., Bloom, E.M. and Black, I.B., 1981, Characterization of a neuronal growth factor from mouse heart-cell-conditioned medium, Dev. Biol. 82:56–68.CrossRefGoogle Scholar
  28. Cowan, W.M., 1973, Neuronal death as a regulative mechanism in the control of cell number in the nervous system, in: Development and Aging in the Nervous System, (M. Rockstein, ed.), New York, Academic Press, pp. 19–41.Google Scholar
  29. Cowan, W.M., Martin, A.H. and Wenger, E.L., 1968, Mitotic patterns in the optic tectum of the chick during normal development and after early removal of the optic vesicle, J. Exp. Zool. 169:71–92.CrossRefGoogle Scholar
  30. Creazzo, T.L. and Sohal, G.S., 1979, Effects of chronic injections of β-bungarotoxin on embryonic cell death, Exp. Neurol. 66:135–145.CrossRefGoogle Scholar
  31. Cunningham, T.J., 1982, Naturally-occurring neuron death and its regulation by developing neural pathways, in: International Review of Cytology, (G.H. Bourne and J.F. Danielli, eds.), New York, Academic Press, pp. 163–186.Google Scholar
  32. Currie, J. and Cowan, W.M., 1974, Some observations on the early development of the optic tectum in the frog (Rana pipiens), with special reference to the effects of early eye removal on mitotic activity in the larval tectum, J. Comp. Neurol. 156:123–142.CrossRefGoogle Scholar
  33. Davis, H.L., 1981, Effect of nerve extract on atrophy of denervated or immobilized muscles, Soc. Neurosci. Abstract 7:946.Google Scholar
  34. Dennis, M., 1981, Development of the neuromuscular junction: inductive interactions between cells, Ann. Rev. Neurosci. 4:43–68.CrossRefGoogle Scholar
  35. Detwiler, S.R., 1936, Neuroembryology, Macmillan, New York.Google Scholar
  36. Drachman, D.B. (ed.), 1974, Trophic Functions of the Neuron, New York Academy of Sciences, New York.Google Scholar
  37. Dribin, L.B. and Barrett, J.N., 1980, Conditioned medium enhanced neurite outgrowth from rat spinal cord explants, Dev. Biol. 74:184–195.CrossRefGoogle Scholar
  38. Edgar, D., Barde, Y.-A. and Thoenen, H., 1981, Subpopulations of cultured chick sympathetic neurons differ in their requirements for survival factors, Nature 289:294–295.CrossRefGoogle Scholar
  39. Edwards, C., 1979, The effects of innervation on the properties of acetylcholine receptors in muscle, Neurosci. 4:565–584.CrossRefGoogle Scholar
  40. English, A.W. and Ledbetter, W.D., 1982, Anatomy and innervation patterns of cat lateral gastrocnemius and plantaris muscles, Amer. J. Anat. 164:67–77.CrossRefGoogle Scholar
  41. Fambrough, D.M., 1979, Control of acetylcholine receptors in skeletal muscle, Physiol. Rev. 59:165–227.Google Scholar
  42. Fox, G.Q. and Richardson, G.P., 1981, Cell death and proliferation in the electric lobes of Torpedo mamorata, Soc. Neurosci. Abstract 7:293.Google Scholar
  43. Gauthier, G.F., Lowey, S., Benfield, P.A. and Hobbs, A.W., 1982, Distribution and properties of myosin isozymes in developing avian and mammalian skeletal muscle fibers, J. Cell. Biol. 92:471–484.CrossRefGoogle Scholar
  44. Gaze, R.M. and Keating, M.J., 1972, The visual system and “neuronal specificity”, Nature 237:375–378.CrossRefGoogle Scholar
  45. Gilmer-Waymire, K. and Appel, S.H., 1981, The appearance of muscle derived proteins in nerve and their enhancement with a -BTX in vivo, Soc. Neurosci. Abstract 7:767.Google Scholar
  46. Glucksmann, A., 1951, Cell deaths in normal vertebrate ontogeny, Biol. Rev. 26:59–86.CrossRefGoogle Scholar
  47. Godfrey, E.W., Schrier, B.K. and Nelson, P.G., 1980, Source and target cell specificities of a conditioned medium factor that increases choline acetyltransferase activity in cultured spinal cord, Dev. Biol. 77:403–418.CrossRefGoogle Scholar
  48. Goldspink, D.F. (ed.), 1980, Development and Specialization of Skeletal Muscle, Cambridge, England, Cambridge University Press.Google Scholar
  49. Gorin, P.D. and Johnson, E.M., 1980a, Effects of exposure to nerve growth factor antibodies on the developing nervous system of the rat: an experimental approach, Dev. Biol. 80:313–323.CrossRefGoogle Scholar
  50. Gorin, P.D. and Johnso, E.M., 1980b, Effects of long-term nerve growth factor deprivation on the nervous system of the adult rat: an experimental autoimmune approach, Brain Res. 198:27–42.CrossRefGoogle Scholar
  51. Gould, S.J., 1977, Ontogeny and Phylogeny, Cambridge, MA., Belknap.Google Scholar
  52. Grumet, M., Rutishauser, U. and Edelman, G.M., 1982, Neural cell adhesion molecule is on embryonic muscle cells and mediates adhesion to nerve cells in vitro, Nature, 295:693–695.CrossRefGoogle Scholar
  53. Hamburger, V., 1958, Regression versus peripheral control of differentiation in motor hypoplasia, Amer. J. Anat. 102:365–410.CrossRefGoogle Scholar
  54. Hamburger, V., 1975, Cell death in the development of the lateral motor column of the chick embryo, J. Comp. Neurol. 160:535–546.CrossRefGoogle Scholar
  55. Hamburger, V., Brunso-Bechtold, J.K. and Yip, J., 1981, Neuronal death in the spinal ganglia of the chick embryo and its reduction by nerve growth factor, J. Neurosci. 1:60–71.Google Scholar
  56. Hamburger, V. and Levi-Montalcini, R., 1949, Proliferation, differentiation and degeneration in the spinal ganglia of the chick embryo under normal and experimental conditions, J. Exp. Zool. 111: 457–502.CrossRefGoogle Scholar
  57. Hamburger, V. and Oppenheim, R.W., 1982, Naturally-occurring neuronal death in vertebrates. Neurosci. Comment 1. 2:39–55.Google Scholar
  58. Hamburger, V., Wenger, E. and Oppenheim, R.W., 1966, Motility in the chick embryo in the absence of sensory input, J. Exp. Zool. 165:133–160.CrossRefGoogle Scholar
  59. Hanson, P.A. and Strominger, N.L., 1980, Intrauterine motor neuron death in normal mouse and in the Wobbler mutant, Soc. Neurosci. Abstract 6:669.Google Scholar
  60. Harris-Flanagan, A., 1969, Differentiation and degeneration in the motor horn of foetal mouse, J. Morph. 129:281–305.CrossRefGoogle Scholar
  61. Harrison, R.G., An experimental study of the relation of the nervous system to the developing musculature in the embryo of the frog, Amer. J. Anat. 3:197–220.Google Scholar
  62. Harrison, R.G., 1933, Some difficulties of the determination problem, Amer. Nat. 67:306–321.CrossRefGoogle Scholar
  63. Hasegawa, S. and Kuromi, H., 1978, Ventral part of spinal cord contains the neurotrophic factor for the action potential of cultured muscle, Brain Res. 157:153–156.CrossRefGoogle Scholar
  64. Hayes, B.P. and Webster, E.E., 1981, Neurons situated outside the isthmo-optic nucleus and projecting to the eye in adult birds, Neurosci. Lett. 26:107–112.CrossRefGoogle Scholar
  65. Hendry, I.A., 1976, Control in the development of the vertebrate sympathetic nervous system, Rev. Neurosci. 2:149–193.Google Scholar
  66. Hendry, I.A. and Campbell, J., 1976, Morphometric analysis of rat superior cervical ganglion after axotomy and nerve growth factor treatment, J. Neurocytol. 5:351–360.CrossRefGoogle Scholar
  67. Hendry, I.A. and Hill, C.E., 1980, Retrograde axonal transport of target tissue-derived macromolecules, Nature 287:647–649.CrossRefGoogle Scholar
  68. Hendry, I.A., Stockel, K., Thoenen, H. and Iverson, L.L., 1974, The retrograde axonal transport of nerve growth factor, Brain Res. 68:103–131.CrossRefGoogle Scholar
  69. Hess, A., 1970, Vertebrate slow muscle fibers, Physiol. Rev. 68:103–131.Google Scholar
  70. His, W., 1884, Unsere Korperform und das Physiologische Problem ihrer Entstehung, Leipzig, Vogel.Google Scholar
  71. Hollyday, M., 1980, Motoneuron histogenesis and the development of limb innervation. in: Current Topics in Developmental Biology, Neural Development, vol. 15, (R.K. Hunt, ed.), New York, Academic Press, pp. 181–215.Google Scholar
  72. Hollyday, M. and Hamburger, V., 1976, Reduction of the naturally occurring motor neuron loss by enlargement of the periphery, J. Comp. Neurol. 170:311–320.CrossRefGoogle Scholar
  73. Hollyday, M. and Hamburger, V., 1977, An autoradiographic study of the formation of the lateral motor column in the chick embryo, Brain Res. 132:197–208.CrossRefGoogle Scholar
  74. Holtzer, H., 1970, Myogenesis, in: O.A. Schjkeide and J. DeVellis (eds.) Cell Differentiation, New York, Van Nostrand Reinhold.Google Scholar
  75. Hughes, A.F., 1968, Aspects of Neural Development, London, Logos.Google Scholar
  76. Innocenti, G., 1982, Transitory structures as a substrate for developmental plasticity of the brain, in: Recovery from Brain Damage, (M.W. Van Hof and J. Mohn, eds.), Amsterdam, Elsevier (in press).Google Scholar
  77. Jacobson, M., 1978, Developmental Neurobiology, New York: Plenum.Google Scholar
  78. Jessel, T.M., Siegel, R.E. and Fischbach, G.D., 1979, Induction of acetylcholine receptors on cultured skeletal muscle by a factor extracted from brain and spinal cord, Proc. Natl. Acad. SC. USA. 76:5397–5401.CrossRefGoogle Scholar
  79. Katz, M.J. and Lasek, R.J., 1978, Evolution of the nervous system: role of ontogenetic buffer mechanisms in the evolution of matching populations, Proc. Natl. Acad. SC. USA. 75:1349–1352.CrossRefGoogle Scholar
  80. Kelly, J.P. and Cowan, W.M., 1972, Studies on the development of the chick optic tectum. III. Effects of early eye removal. Brain Res. 42:263–288.CrossRefGoogle Scholar
  81. Kikuchi, T. and Ashmore, C.R., 1976, Developmental aspects of the innervation of skeletal muscle fibers in the chick embryo, Cell Tiss. Res. 171:233–251.CrossRefGoogle Scholar
  82. Kollros, J.J., 1953, The development of the optic lobes in the frog. I. The effects of unilateral enucleation in embryonic stages, J. Exp. Zool. 123:153–187.CrossRefGoogle Scholar
  83. Kollros, J.J., 1982, Peripheral control of midbrain mitotic activity in the frog, J. Comp. Neurol. 205:171–178.CrossRefGoogle Scholar
  84. Laing, N. and Prestige, M., 1978, Prevention of spontaneous motoneurone death in chick embryos, J. Physiol. 282:33–34P.Google Scholar
  85. Lamb, A.H., 1976, The projection patterns of the ventral horn in the hindlimb during development, Dev. Biol. 52:82–99.CrossRefGoogle Scholar
  86. Lamb, A.H., 1979, Ventral horn cell counts in Xenopus with naturally occurring supernumerary hindlimbs, J. Embryol. Exp. Morph. 49:13–16.Google Scholar
  87. Lamb, A.H., 1980, Motoneurone counts in Xenopus frogs reared with one bilaterally-innervated hindlimb, Nature 284:347–350.CrossRefGoogle Scholar
  88. Lamb, A.H., 1981, Target dependency of developing motoneurons in Xenopus laevis, Comp. Neurol. 203:157–171.CrossRefGoogle Scholar
  89. Lance-Jones, C. and Landmesser, L., 1981, Pathway selection by embryonic chick motoneurons in an experimentally altered environment, Proc. Roy. Soc. Lond. B, 214:19–52.CrossRefGoogle Scholar
  90. Lance-Jones, C., 1982, Motoneuron cell death in the developing lumbar spinal cord of the mouse, Dev. Brain Res, (in press).Google Scholar
  91. Landmesser, L., 1980, The generation of neuromuscular specificity, Ann. Rev. Neurosci. 3:279–302.CrossRefGoogle Scholar
  92. Landmesser, L. and Morris, D.G., 1975, The development of functional innervation in the hind limb of the chick embryo, J. Physiol. 249:301–326.Google Scholar
  93. Landmesser, L. and Pilar, G., 1972, The onset and development of transmission in the chick ciliary ganglion, J. Physiol. 222:691–713.Google Scholar
  94. Landmesser, L. and Pilar, G., 1974, Synapse formation during embryo-genesis on ganglion cells lacking a periphery, J. Physiol. 241:714–736.Google Scholar
  95. Landmesser, L. and Pilar, G., 1978, Interactions between neurons and their targets during in vivo synaptogenesis, Fed. Proceed. 37:2016–2022.Google Scholar
  96. Lentz, T.L., Addis, J.S. and Chester, J., 1981, Partial purification and characterization of a nerve trophic factor regulating muscle acetylcholinesterase activity, Exp. Neurol. 73:542–557.CrossRefGoogle Scholar
  97. Levi-Montalcini, R., 1972, The morphological effects of immunosympathectomy. in: Immunosympathectomy, (G. Steiner and E. Schonbaum, eds.) New York, Elsevier, pp. 55–78.Google Scholar
  98. Levi-Montalcini, R., 1974, NGF: an uncharted route in: The Neuro-sciences: Paths of Discovery, (F.G. Worden, J.P. Swazey and G. Adelman, eds.), Cambridge, MIT Press pp. 245–265.Google Scholar
  99. Levi-Montalcini, R. and Levi, G., 1942, Les conseguences de la destruction d’un territoire d’innervation peripherigue sur le developpment des centres nerveux correspondants dans l’embryon de poulet, Arch. Biol. 53:537–545.Google Scholar
  100. Levi-Montalcini, R. and Levi, G., 1944, Correlazioni nello sviluppo tra varie parti del sistema nervoso. I. Conseguenze della demolizione dell’abbozoo di um arto sui centri nervosi cell’embrione di polio, Comment. Pontif. Acad. Sci. 8:527–578.Google Scholar
  101. Lewis, J., 1980, Death and the neurone, Nature 284:305–306.CrossRefGoogle Scholar
  102. Lomo, T., 1980, What controls the development of neuromuscular junctions? Trends Neurosci. 3:126–219.CrossRefGoogle Scholar
  103. Lyles, J.M. and Barnard, E.A., 1980, Disappearance of the endplate form of acetylcholinesterase from a slow tonic muscle, FEBS Lett. 109:9–12.CrossRefGoogle Scholar
  104. Lyles, J.M., Silman, I. and Barnard, E.A., 1979, Developmental changes in levels and forms of cholinesterases in muscles of normal and dystrophic chickens, J. Neurochem. 33:727–738.CrossRefGoogle Scholar
  105. MacNaughton, J.V., 1974, An ultrastructural and histochemical study of fibre types in the pectoralis thoracica and iliotibialis muscles of the fowl, J. Anat. 118:171–186.Google Scholar
  106. McLennan, I.S., 1981, Size of motoneuron pool is related to number of myotubes in developing muscle, Soc. Neurosci. Abstract, 7:291.Google Scholar
  107. Maderdrut, J.L., and Oppenheim, R.W., 1982, Reduction of naturally-occurring cell death in the thoraco-lumber and sacral preganglionic cell column of the chick embryo following blockade of ganglionic transmission, Soc. Neurosci. Abstract 8:1638.Google Scholar
  108. Markelonis, G.J., Oh, T.H., Elderfrawi, M.E. and Guth, L., 1982, Sciatin: A myotrophic protein increases the number of acetylcholine receptors and receptor clusters in cultured skeletal muscle, Dev. Biol. 89:383–361.CrossRefGoogle Scholar
  109. Massoulie, J. and Bon, S., 1982, The molecular forms of Cholinesterase and acetylcholinesterase in vertebrates, Ann. Rev. Neurosci. 5:57–106.CrossRefGoogle Scholar
  110. Murphy, B.J., 1977, An analysis of myogenic and neurogenic influences on the development of muscular dystrophy in the chick embryo, Dissertation, Louisiana State University Medical Center.Google Scholar
  111. Nishi, R. and Berg, D., 1981, Two components from eye tissue that differentially stimulate the growth and development of ciliary ganglion neurons in culture, J. Neurosci. 1:505–513.Google Scholar
  112. Nurcombe, V., McGrath, P.A. and Bennett, M.R., 1981, Postnatal death of motor neurons during the development of the brachial spinal cord of the rat, Neurosci. Lett. 27:249–254.CrossRefGoogle Scholar
  113. Okada, N. and Oppenheim, R.W., 1981, Developmental changes in the lateral motor column of the chick embryo following either spinal transection or neural crest removal, Soc. Neurosci. Abstract. 7:291.Google Scholar
  114. O’Leary, D.D.M. and Cowan, W.M., 1981, Further observations on the development of the nucleus of origin of centrifugal fibers in the avian retina, Soc. Neurosci. Abstract 7:293.Google Scholar
  115. Ontell, M., 1977, Neonatal muscle: an electron microscopic study, Anat. Rec. 189:669–690.CrossRefGoogle Scholar
  116. Ontell, M. and Dunn, R.F., 1978, Neonatal muscle growth: a guantita-tive study, Amer. J. Anat. 152:539–556.CrossRefGoogle Scholar
  117. Oppenheim, R.W., 1975, The role of supraspinal input in embryonic motility: a re-examination in the chick, J. Comp. Neurol. 160:37–50.CrossRefGoogle Scholar
  118. Oppenheim, R.W., 1981a, Neuronal cell death and some related regressive phenomena during neurogenesis: a selective historical review and progress report. In: Studies in Developmental Neurobiology, Essays in Honor of Viktor Hamburger, (W.M. Cowan, ed.), New York, Oxford University Press, pp. 74–133.Google Scholar
  119. Oppenheim, R.W., 1981b, Cell death of motoneurons in the chick embryo spinal cord. V. Evidence on the role of cell death and neuromuscular function in the formation of specific peripheral connections, J. Neurosci. 1:141–151.Google Scholar
  120. Oppenheim, R.W., 1981c, Ontogenetic adaptations and retrogressive processes in the development of the nervous system and behavior. A neuroembryological perspective, in Maturation and Development: Biological and Psychological Perspectives, (K. Connolly and H. Prechtl, eds.), Philadelphia, J.P. Lippincott, pp. 73–109.Google Scholar
  121. Oppenheim, R.W., 1982, Preformation and epigenesis in the origins of the nervous system and behavior: Issues, concepts and their history. In: Perspectives in Ethology, vol. 5. (P. Bateson and P. Klopfer, eds.), New York, Plenum, (in press).Google Scholar
  122. Oppenheim, R.W., 1982, Reduction of neuronal death by embryonic neuromuscular blockade persists after hatching, Soc. Neurosci. Abstract 8:708.Google Scholar
  123. Oppenheim, R.W., and Chu-Wang, I.-W., 1977, Spontaneous cell death of spinal motoneurons following peripheral innervation in the chick embryo, Brain Res. 125:154–160.CrossRefGoogle Scholar
  124. Oppenheim, R.W. and Chu-Wang, I.-W., 1982, Aspects of naturally-occurring cell death in the chick spinal cord: somatic motoneurons. In: Somatic and Autonomic Nerve-Muscle Interactions, (G. Burnstock, G. Vrbova and R. O’Brien, eds.), Elsevier/North-Holland, Amsterdam (in press).Google Scholar
  125. Oppenheim, R.W. and Maderdrut, J.L., 1981, Pharmacological modulation of neuromuscular transmission and cell death in the lateral motor column of the chick embryo, Soc. Neurosci. Abstract 7:291.Google Scholar
  126. Oppenheim, R.W., Maderdrut, J.L. and Wells, D., 1982, Cell death of motoneurons in the chick embryo spinal cord VI. Reduction of naturally-occurring cell death in the thoraco-lumbar column of Terni by nerve growth factor, J. Comp. Neurol. (in press).Google Scholar
  127. Oppenheim, R.W. and Majors-Willard, C., 1978, Neuronal cell death in the brachial spinal cord of the chick is unrelated to the loss of polyneuronal innervation in wing muscle, Brain Res. 154:148–152.CrossRefGoogle Scholar
  128. Oppenheim, R.W. and Nunez, R., 1982, Electrical stimulation of hindlimb increases neuronal cell death in chick embryo, Nature 295:57–59.CrossRefGoogle Scholar
  129. Oppenheim, R.W., Rose, L.L. and Stokes, B., 1982, Cell death of motoneurons in the chick embyro spinal cord. VII. The survival of brachial motoneurons in dystrophic chickens, Exp. Neurol, (in press).Google Scholar
  130. Oppenheimer, J., 1967, Essays in the History of Embryology and Biology, Cambridge, MIT Press.Google Scholar
  131. Parks, T.N., 1979, Afferent influences on the development of the brain stem auditory nuclei of the chicken; otocyst ablation, J. Comp. Neurol. 183:665–678.CrossRefGoogle Scholar
  132. Pearson, J., Axelrod, F. and Dancis, J., 1974, Current concepts of dysautonomia: neuropathological defects, Neurol. 21:486–493.Google Scholar
  133. Pearson, J. and Pytel, B.A., 1978, Quantitative studies of sympathetic ganglia and spinal cord intermedio-lateral gray columns in familial dysautonomia, J. Neurol. Sci. 39:47–59.CrossRefGoogle Scholar
  134. Pettigrew, A.G., Lindeman, R. and Bennett, M.R., 1979, Development of the segmental innervation of the chick forelimb, J. Embryol. Exp. Morph. 49:115–137.Google Scholar
  135. Pittman, R. and Oppenheim, R.W., 1979, Cell death of motoneurons in the chick embryo spinal cord, IV. Evidence that a functional neuromuscular interaction is involved in the regulation of naturally occurring cell death and stabilization of synapses, J. Comp. Neurol. 187:425–446.CrossRefGoogle Scholar
  136. Pockett, S., 1981, Elimination of polyneuronal innervation in proximal and distal leg muscles of chick embryos, Dev. Brain Res. 1:299–302.CrossRefGoogle Scholar
  137. Pollack, E.D., 1980, Target-dependent survival of tadpole spinal cord neurites in tissue culture, Neurosci. Lett. 16:269–274.CrossRefGoogle Scholar
  138. Pollack, E.D. and Muhlach, W.L., 1981, Stage dependency in eliciting target-dependent enhanced neurite outgrowth from spinal cord expiants in vitro, Dev. Biol. 86:259–263.CrossRefGoogle Scholar
  139. Popiela, H. and Ellis, S., 1981, Neurotrophic factor: characterization and partial purification, Dev. Biol. 83:266–277.CrossRefGoogle Scholar
  140. Prestige, M., 1967, The control of cell number in the lumbar ventral horn during the development of Xenopus laevis tadpoles, J. Embryol. Exp. Morph. 18:359–387.Google Scholar
  141. Purves, D., 1980, Neuronal competition, Nature 287:585–586.CrossRefGoogle Scholar
  142. Purves, D. and Lichtman, J.W., 1980, Elimination of synapses in the developing nervous system, Science 210:153–157.CrossRefGoogle Scholar
  143. Romer, A. 1927, The development of the thigh musculature of the chick, J. Morph and Physiol. 43:347–385.CrossRefGoogle Scholar
  144. Roux, W., 1894, The problems, methods, and scope of developmental mechanics (transi, by W.M. Wheeler) in Woods Hole Biological Lectures, Marine Biological Station, Woods Hole, 8th Lecture: 149–189.Google Scholar
  145. Ruffolo, R.R., Eisenbarth, G.S., Thompson, J.M. and Nirenberg, M., 1978, Synapse turnover: a mechanism for acquiring synaptic specificity, Proc. Natl. Acad. Sci. USA. 75: 2281–2285.CrossRefGoogle Scholar
  146. Sanes, J.R. and Hall, Z.W., 1979, Antibodies that bind specifically to synaptic sites on muscle fiber basal lamina, J. Cell Biol. 83:357–370.CrossRefGoogle Scholar
  147. Sanes, J.R., Marshall, L.M. and McMahan, U.J., 1978, Reinnervation of muscle fiber basal lamina after removal of myofibers, J. Cell Biol. 78:176–198.CrossRefGoogle Scholar
  148. Scaravilli, F. and Duchen, L.W., 1980, Electron microscopic and quantitative studies of cell necrosis in developing sensory ganglia in normal and Sprawling mutant mice, J. Neurocytol.9:373–380.CrossRefGoogle Scholar
  149. Schaub, M.C. and Watterson, J.G., 1981, Control of the contractile process in muscle, Trends Pharmacol. Sci. 2:279–282.CrossRefGoogle Scholar
  150. Schwartz, J.P and Breakfield, X.O., 1980, Altered nerve growth factor in fibroblasts from patients with familial dysautonomia, Proc. Natl. Acad. Sci. USA 77:1154–1158.CrossRefGoogle Scholar
  151. Silver, J., 1978, Cell death during development of the nervous system, in: Handbook of Sensory Physiology, vol. 9 (M. Jacobson, ed.), Berlin, Springer, pp. 419–436.Google Scholar
  152. Singer, M., 1959, The influence of nerves on regeneration, in: Regeneration in Vertebrates, (C.S. Thornton, ed.), Chicago, University of Chicago, pp. 59–80.Google Scholar
  153. Smith, R.G. and Appel, S.H., 1981, Evidence for a skeletal muscle protein that enhances neuron survival, neurite extension and acetylcholine (ACh) synthesis, Soc. Neurosci Abstract 7:144.Google Scholar
  154. Stockdale, F.E., Raman, N. and Baden, H., 1981, Myosin light chains and the developmental origin of fast muscle, Proc. Natl. Acad. Sci. USA. 78:931–935.CrossRefGoogle Scholar
  155. Sullivan, G.E., 1962, Anatomy and embryology of the wing musculature of the domestic fowl, Austral. J. Zool. 10:458–518.CrossRefGoogle Scholar
  156. Susheela, A.K. Seraydarian, M. and Abbott, B.C., 1980, Increase of alpha motor neurons in chicken afflicted with muscular dystrophy, Exp. Neurol. 67:453–458.CrossRefGoogle Scholar
  157. Swett, J., Eldred, E. and Buchwald, J.A., 1970, Somatotopic cord-to-muscle relations in efferent innervation of cat gastrocnemius, Amer. J. Physiol. 40:762–766.Google Scholar
  158. Thoenen, H. and Barde, Y.-A., 1980, Physiology of nerve growth factor, Physiol. Rev. 60:1284–1335.Google Scholar
  159. Thoenen H., Otten, U., and Schwab, M., 1979, Orthograde and retrograde signals for the regulation of neuronal gene expression: the peripheral sympathetic nervous system as a model. In: The Neurosciences, Fourth Study Program, (F.O. Schmitt and F.G. Worden eds.), Cambridge, Massachusetts, MIT Press, pp. 911–928.Google Scholar
  160. Twitty, V., 1932, Influence of the eye on the growth of its associated structures, studied by means of heteroplastic transplantation, J. Exp. Zool. 61:333–374.CrossRefGoogle Scholar
  161. Varon, S.S. and Bunge, R.P., 1978, Trophic mechanisms in the peripheral nervous system, Ann. Rev. Neurosci. 1:327–361.CrossRefGoogle Scholar
  162. Vrbova, G., Gordon, T. and Jones, R., 1978, Nerve-Muscle Interactions. London, Chapman and Hall.CrossRefGoogle Scholar
  163. Weeds, A., 1978, Myosin: polymorphism and promiscuity, Nature 274:417–418.CrossRefGoogle Scholar
  164. Wenger, E.L., 1950, An experimental analysis of relations between parts of the brachial spinal cord of the embryonic chick, J. Exp. Zool. 114:51–85.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Ronald W. Oppenheim
    • 1
    • 2
  1. 1.Department of Anatomy Bowman Gray School of MedicineWake Forest UniversityWinston SalemUSA
  2. 2.Neurobiology ProgramUniversity of North CarolinaChapel HillUSA

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