Ordered Nerve Connections: Pathways and Maps

  • R. M. Gaze
Part of the NATO ASI Series book series (NSSA, volume 78)


The idea that orderly neuronal interconnections are based on chemoselective recognition between the cells and their processes was proposed by Cajal (1892) and given experimental support by the work of Langley (1895). In its present form the hypothesis of neuronal specificity, as it is now called, derives largely from the work of Sperry (1943; 1944; 1945; 1951; 1963; 1965) and it proposes that interconnecting populations of neurones each acquire positionally dependent chemoselectivity labels, or markers, early in development, and that properly ordered interconnections between the populations are based on selective affinities between the markers carried by one population and those carried by the other.


Optic Nerve Optic Tract Optic Tectum Optic Nerve Fibre Temporal Fiber 
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  1. Attardi, D.G. and Sperry, R.W., 1963, Preferential selection of central pathways by regenerating optic fibres, Exp. Neurol., 7:46–64.CrossRefGoogle Scholar
  2. Cajal, S.R., 1892, The structure of the retina. English Translation, 1972, Charles C. Thomas, Springfield.Google Scholar
  3. Fawcett, J.W. and Gaze, R.M., 1982, The retinotectal fiber pathways from normal and compound eyes in Xenopus, J. Embryol. exp. Morph., in press.Google Scholar
  4. Fujisawa, H., Wakanabe, K., Tani, N. and Ibata, Y., 1981a, Retino-topic analyses of fiber pathways in amphibians. I. The adult newt, Cynops pyrrhogaster. Brain Res., 206:9–20.CrossRefGoogle Scholar
  5. Fujisawa, H., Wakanabe, K., Tani, N. and Ibata, Y., 1981b, Retino-topic analyses of fiber pathways in amphibians. II. The frog Rana nigromaculata. Brain Res., 206:21–26.CrossRefGoogle Scholar
  6. Gaze, R.M., Chung, S.-H. and Keating, M.J., 1972, Development of the retinotectal projection in Xenopus, Nature, 236:133–135.CrossRefGoogle Scholar
  7. Gaze, R.M. and Grant, P., 1978, The diencephalic course of regenerating retinotectal fibres in Xenopus tadpoles, J. Embryol. exp. Morph., 44:201–216.Google Scholar
  8. Gaze, R.M. and Hope, R.A., 1976, The formation of continuously ordered mappings, Prog. Brain Res., 45:327–355.CrossRefGoogle Scholar
  9. Gaze, R.M. and Hope, R.A., 1982, The visuotectal projection following translocation of grafts within an optic tectum in the goldfish, J. Physiol. Lond., in press.Google Scholar
  10. Gaze, R.M., Jacobson, M. and Szekely, G., 1963, The retinotectal projection in Xenopus with compound eyes, J. Physiol. Lond., 165:484–499.Google Scholar
  11. Gaze, R.M., Keating, M.J. and Chung, S.-H., 1974, The evolution of the retinotectal map during developing in Xenopus, Proc. Roy. Soc. Lond. B 185:301–330.CrossRefGoogle Scholar
  12. Gaze, R.M., Keating, M.J., Ostberg, A., and Chung, S.-H., 1979, The relationship between retinal and tectal growth in larval Xenopus: implications for the development of the retinotectal projection , J. Embryol. exp. Morph., 53:103–143.Google Scholar
  13. Gaze, R.M. and Sharma, S.C., 1970, Axial differences in the reinnervation of the goldfish optic tectum by regenerating optic nerve fibres, Exp. Brain Res., 10:171–181.CrossRefGoogle Scholar
  14. Gaze, R.M. and Straznicky, C., 1980, Regeneration of optic nerve fibres from a compound eye to both tecta in Xenopus: evidence relating to the state of specification of the eye and the tectum, J. Embryol. exp. Morph., 60:125–140.Google Scholar
  15. Giorgi, P.P. and Van der Loos, H., 1978, Axons from eyes grafted in Xenopus can grow into the spinal cord and reach the optic tectum, Nature, 275:746–748.CrossRefGoogle Scholar
  16. Glastonbury, J. and Straznicky, K., 1978, Aberrant ipsilateral retinotectal projection following optic nerve section in Xenopus, Neuroscience Letts., 7:67–72.CrossRefGoogle Scholar
  17. Hope, R.A., Hammond, B.J. and Gaze, R.M., 1976, The arrow model: retinotectal specificity and map formation in the goldfish visual system, Proc. Roy. Soc. Lond. B 194:447–466.CrossRefGoogle Scholar
  18. Horder, T.J., 1971, Retention by fish optic nerve fibres regenerating to new terminal sites in the tectum of “chemospecific” affinity for their original sites, J. Physiol. Lond., 216:53–55P.Google Scholar
  19. Jacobson, M. and Levine, R.L., 1975, Stability of implanted duplicated tectal positional markers serving as targets for optic axons in adult frogs, Brain Res., 92:468–471.CrossRefGoogle Scholar
  20. Langley, J.N., 1895, A note on the regeneration of preganglion fibres in the cat sympathetic system, J. Physiol. Lond., 18:280–284.Google Scholar
  21. Nieuwkoop, P.D. and Faber, J., 1956, Normal Table of Xenopus laevis, (Daudin), Amsterdam: North Holland.Google Scholar
  22. Schmidt, J.T., 1978, Retinal fibers alter tectal positional markers during the expansion of the half retinal projection in goldfish, J. comp. Neurol., 177:279–300.CrossRefGoogle Scholar
  23. Sperry, R.W., 1943, Visuomotor coordination in the newt (Tritinus viridescens) after regeneration of the optic nerve, J. comp. Neurol., 79:33–55.CrossRefGoogle Scholar
  24. Sperry, R.W., 1944, Optic nerve regeneration with return of vision in aurans, J. Neurophysiol., 7:57–70.Google Scholar
  25. Sperry, R.W., 1945, Restoration of vision after crossing of optic nerves and after contralateral transplantation of eye, J. Neurophysiol., 8:15–18.Google Scholar
  26. Sperry, R.W., 1951, Mechanisms of neural maturation, In: Handbook of Experimental Psychology, S.S. Stevens (Ed.), Wiley, New York, pp. 236–280.Google Scholar
  27. Sperry, R.W., 1963, Chemoaffinity in the orderly growth of nerve fiber patterns and connections, Proc. Nat. Acad. Sc. (U.S.A), 50:703–710.CrossRefGoogle Scholar
  28. Sperry, R.W., 1965, Embryogenesis of behavioural nerve ends (?) in Organogenesis, R.L. DeHann and Unspring, H. (Eds.), Holt, Rienehand and Winston, New York, pp. 161–186.Google Scholar
  29. Steedman, J.G., 1981, Pattern formation in the visual pathways of Xenopus laevis., Ph.D. Thesis, London.Google Scholar
  30. Straznicky, K. and Gaze, R.M., 1971, The growth of the retina in Xenopus laevis: an autoradiographic study, J. Embryol. exp. Morph., 26:67–79.Google Scholar
  31. Straznicky, K. and Gaze, R.M., 1972, The development of the tectum in Xenopus laevis: an autoradiographic study, J. Embryol. exp. Morph., 28:87–115.Google Scholar
  32. Straznicky, C., Gaze, R.M. and Horder, T.J., 1979, Selection of appropriate medial branch of the optic tract by fibres of ventral retinal origin during development and in regeneration: an autoradiograph study in Xenopus, J. Embryol. exp. Morph., 50:253–267.Google Scholar
  33. Straznicky, K., Gaze, R.M. and Keating, M.J., 1974, The retinotectal projection from a double-ventral compound eye in Xenopus laevis, J. Embryol. exp. Morph., 31:123–137.Google Scholar
  34. Straznicky, C., Gaze, R.M. and Keating, M.J., 1981, The development of the retinotectal projections from compound eyes in Xenopus, J. Embryol. exp. Morph., 62:13–35.Google Scholar
  35. Yoon, M.G., 1972, Transposition of the visual projection from the nasal hemiretina onto the foreign rostral zone of the optic tectum in goldfish, Exp. Neurol., 37:451–462.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • R. M. Gaze
    • 1
  1. 1.National Institute for Medical ResearchLondonEngland

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