The Generation of Binocular Maps in the Hamster Superior Colliculus: Normal and Neonatally Enucleated Animals

  • Ian Thompson
Part of the NATO ASI Series book series (NSSA, volume 78)


In the mammalian retinotectal projection, the existence of direct binocular projections exhibiting congruent binocular receptive fields requires that the nasotemporal axis of the retina displays mapping rules of opposite polarity for the crossed and uncrossed projections. The aberrant ipsilateral retinotectal projection arising after neonatal removal of one eye has been mapped in the hamster to investigate possible strategies for determining the normal differences in mapping polarity. The ipsilateral retinotectal projection in enucleates displays a dual representation which is mirror-symmetric about the representation of the temporal retinal margin. In rostral tectum, temporal retina maps with a polarity appropriate for an uncrossed projection whereas in caudal tectum both temporal and nasal retina are mapped, with a polarity appropriate for a crossed projection. Although two mapping polarities are present in a single projection, neighbour relations are preserved insofar as adjacent points on the tectum receive input from adjacent points on the retina. Possible implications of this mapping will be discussed.


Receptive Field Superior Colliculus Mapping Rule Retinal Projection Temporal Retina 


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  1. Bunt, S., R.D. Lund and P.W. Land, 1983, Prenatal development of the optic projection in albino and hooded rats. Dev. Brain Res., 6:149–168.CrossRefGoogle Scholar
  2. Cowey, A., and V.H. Perry, 1979, The projection of the temporal retina in rats, studied by retrograde transport of horseradish peroxidase, Exp. Brain Res., 35:45 7–464.Google Scholar
  3. Cunningham, T.J., and G. Speas, 1975, Inversion of anomalous uncrossed projections along the mediolateral axis of the superior colliculus: implications for retinocollicular specificity, Brain Res., 88:73–79.CrossRefGoogle Scholar
  4. Drager, U.C., and J.F. Olsen, 1980, Origins of crossed and uncrossed retinal projections in pigmented and albino mice, J. Comp. Neurol., 191:383–412.CrossRefGoogle Scholar
  5. Finlay, B.L., K.G. Wilson and G.E. Schneider, 1979, Anomalous ipsi-lateral retinotectal projections in Syrian hamsters with early lesions: topography and functional capacity, J. Comp. Neurol., 183:721–740.CrossRefGoogle Scholar
  6. Frost, D.O., K.-F. So and G.E. Schneider, 1979, Postnatal development of retinal projections in Syrian Hamsters: a study using auto-radiographic and anterograde degeneration techniques, Neuroscience, 4:1649–1677.CrossRefGoogle Scholar
  7. Gaze, R.M., and R.A. Hope, 1976, The formation of continuously ordered mappings, Prog. Brain Res, 45:327–355.CrossRefGoogle Scholar
  8. Guillery, R.W., and J.H. Kaas, 1971, A study of normal and congeni-tally abnormal retinogeniculate projections in cats, J. Comp. Neurol., 143: 72–100.CrossRefGoogle Scholar
  9. Hope, R.A., B.J. Hammond and R.M. Gaze, 1976, The arrow model: retinotectal specificity and map formation in the goldfish visual system, Proc. Roy. Soc. B, 194:447–466.CrossRefGoogle Scholar
  10. Jeffery, G., and V.H. Perry, 1982, Evidence for ganglion cell death during development of the ipsilateral retinal projection in the rat, Dev. Brain Res., 2:176–180.CrossRefGoogle Scholar
  11. Keating, M.J., 1974, The role of visual function in the patterning of binocular visual connections, Br. Med. Bull, 30:145–151.Google Scholar
  12. Kennard, C., 1981, Factors involved in the development of ipsilateral retinothalamic projections in Xenopus laevis, J. Embryol. Exp. Morph, 65:199–217.Google Scholar
  13. Land, P.W. and R.D. Lund, 1979, Development of the rat’s uncrossed retinotectal pathway and its relation to plasticity studies, Science, 205:698–700.CrossRefGoogle Scholar
  14. Levick, W.R., 1972, Another tungsten micro-electrode, Med. Biol. Eng., 10:510–515.CrossRefGoogle Scholar
  15. Lund, R.D. and J.S. Lund, 1976, Plasticity in the developing visual system: the effects of retinal lesions made in young rats, J. Comp. Neurol., 169:133–145.CrossRefGoogle Scholar
  16. Lund, R.D., T.J. Cunningham and J.S. Lund, 1973, Modified optic projections after unilateral eye removal in young rats, Brain Behav. Evol., 8:51–72.CrossRefGoogle Scholar
  17. Merrill, E.G. and A. Ainsworth, 1972, Glass-coated platinum-plated tungsten micro-electrodes, Med. Biol. Eng., 10:662–672.CrossRefGoogle Scholar
  18. Prasada Rao, P.D. and S.C. Sharma, 1982, Retinofugal pathways in juvenile and adult channel catfish, Ictalarus (Ameiurus) punctatus: an HRP and autoradiographic study, J. Comp. Neurol., 210:37–48.CrossRefGoogle Scholar
  19. Rhoades, R.W., 1980, Effects of neonatal enucleation on the functional organization of the superior colliculus in the golden hamster, J. Physiol., 301:383–399.Google Scholar
  20. Rhoades, R.W. and L.M. Chalupa, 1980, Effects of neonatal enucleation on receptive-field properties of visual neurones in the superior colliculus of the golden hamster, J. Neurophysiol., 43:595–611.Google Scholar
  21. Scholes, J.H., 1981, Retinal fiber projection patterns in the primary visual pathways to the brain. In Laverack, M.S. and D.J. Cosens, Eds. “Sense Organs”, pp. 255–275 (Blackie, Glasgow and London).Google Scholar
  22. Sperry, R.W., 1963, Chemoaffinity in the orderly growth of nerve fiber patterns and connections, Proc. Natl. Acad. Sci., 50:703–710.CrossRefGoogle Scholar
  23. Thompson, I.D., 1979, Changes in the uncrossed retinotectal projection after removal of the other eye at birth, Nature, 279:63–66.CrossRefGoogle Scholar
  24. Tiao, Y-C. and C. Blakemore, 1976, Regional specialization in the golden hamster’s retina, J. Comp. Neurol., 168:439–458.CrossRefGoogle Scholar
  25. Tiao, Y-C. and C. Blakemore, 1976, Functional organization in the visual cortex of the golden hamster, J. Comp. Neurol, 168:459–482.CrossRefGoogle Scholar
  26. Tiao, Y-C. and C. Blakemore, 1976, Functional organization in the superior colliculus of the golden hamster, J. Comp. Neurol., 168:483–504.CrossRefGoogle Scholar
  27. Udin, S.B. and M.J. Keating, 1981, Plasticity in a central nervous pathway in Xenopus: anatomical changes in the isthmotectal projection after larval eye rotation, J. Comp. Neurol., 203:575–594.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Ian Thompson
    • 1
  1. 1.The University Laboratory of PhysiologyOxfordEngland

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