Development of Neurotransmitter Systems in the Goldfish Retina
In the adult vertebrate retina, aminobuteric acid (GABA), glycine and dopamine have been localized in particular cell types and their role implicated as neurotransmitter for those cells. The cells have been shown to contain high concentrations of neurotransmitter and its synthetic enzymes and they accumulate the putative transmitter or its precursors. These retinal neurons are also capable of releasing the transmitter in response to an appropriate stimulus (Hall et al., 1974; Robert et al., 1976, for review). In the retina of adult Xenopus laevis, GABA accumulates predominantly in horizontal cells and in certain amacrine cells of the inner nuclear layer (Hollyfield et al., 1979). Similar cell types in the adult goldfish retina also contain GABA; specifically, GABA has been localized in H-l type cone horizontal cells and Ab type pyri-form amacrine cells (Marc et al., 1978).
KeywordsXenopus Laevis Amacrine Cell Ganglion Cell Layer Plexiform Layer Horizontal Cell
Unable to display preview. Download preview PDF.
- Brunn, A. and Ehinger, B., 1972, Uptake of the putative neurotransmitter, glycine, into the rabbit retina. Invest. Ophthalmol., 11:191–198.Google Scholar
- Chin, C.A. and Lam, D.M.K., 1980, The uptake and release of 3H-Glycine in the goldfish retina. J. Physiol. (Lond), 308:185–195.Google Scholar
- Hall, Z.W., Hildebrand, J.G. and Kravitz, E.A., 1974, Chemistry of synaptic transmission, Chiron Press, Newton, Mass.Google Scholar
- Kajishima, T., 1960, The normal developmental stages of the goldfish Carassius auratus. Japan. J. Ichthylology. 8:20–28.Google Scholar
- Marc, R.E., 1980, Retinal colour channels and their neurotransmitters. In Colour Deficiencies V, Institute of Physics, London. Adam Hilger, Ltd., London. pp. 15–29.Google Scholar
- Marc, R.E. and Lam, D.M.K., 1981, Glycinergic pathways in the goldfish retina. J. Neuroscience. 1:152–165.Google Scholar
- Marc, R.E. and Summerall, R.D., 1980, Development of the transmitter systems in the teleost retina. Suppl. Inv. Ophthal. Visual Sci., 20:247.Google Scholar
- Roberts, E., Chase, T. and Tower, D.B., 1976, Gaba in nervous system function. Raven Press, New York.Google Scholar
- Sarthy, P.V., Rayborn, M.E., Hollyfield, J.G. and Lam, D.M.K., The emergence, localization and maturation of neurotransmitter systems during development of the retina in Xenopus laevis. III. Dopamine. J. Comp. Neur., 195:595–602.Google Scholar