In Vivo and in Vitro Studies on the Development of the Peripheral Nervous System

  • Julian Smith
  • Nicole M. Le Douarin
Part of the NATO ASI Series book series (NSSA, volume 78)


The origin of the peripheral nervous system (PNS) is currently attracting considerable attention, both from the embryological and the neurobiological standpoints. The embryologist is fascinated by the problems posed by the differentiation of a variety of distinct cell lines from a unique source — the neural crest — while the neurobiologist is attracted by the relative simplicity of a system the study of which may, in the long term, bear fruit relevant to an understanding of higher brain function. It is not surprising, therefore, that the past few years have witnessed an explosion of interest in this topic, which, accompanied by an increasingly multi-disciplinary approach, has helped to increase significantly our knowledge of the development of sensory and autonomic ganglia during vertebrate embryogenesis. This chapter will be largely concerned with the ontogeny of the PNS in the avian embryo, which has long been the preferred experimental model for a number of obvious practical reasons. At certain points, however, reference will be made to relevant studies performed with mammalian systems.


Neural Tube Neural Crest Neural Crest Cell Crest Cell Nodose Ganglion 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Julian Smith
    • 1
  • Nicole M. Le Douarin
    • 1
  1. 1.Institut d’Embryologie du C.N.R.S.Collège de FranceNogent-sur-MarneFrance

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