Phospholipid Organization in the Membranes of Normal and Abnormal Erythrocytes
Among the various membrane systems studied so far, the erythrocyte membrane definitely is the best characterized one, particularly regarding the localization of its phospholipids. Soon after Bretscher had proposed that the phospholipids in the erythrocyte membrane might be asymmetrically distributed over both halves of the bilayer (see preceeding chapter), Zwaal and coworkers were able to complete the picture of the distribution of all of the main phospholipid classes in the human erythrocyte membrane (1,2). As a logic development, these studies have been subsequently extended to modified and pathologic erythrocytes, in attempts to gain insight into the factors which control the marked phospholipid asymmetry in this membrane.
KeywordsErythrocyte Membrane Human Erythrocyte Membrane Beef Liver Outer Monolayer Outer Membrane Leaflet
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