Use of Synthetic Oligonucleotide Hybridization Probes for the Characterization and Isolation of Cloned DNAs

  • Antonio A. Reyes
  • R. Bruce Wallace
Part of the Genetic Engineering book series (GEPM, volume 6)


The potential usefulness of oligonucleotides as tools for the characterization of specific DNA or RNA sequence has been recognized for a long time. This idea was a direct consequence of the Watson-Crick structure of double-helical DNA. However, it has only been recently that this potential has begun to be realized. Almost simultaneous developments in synthetic DNA chemistry, cloning, DNA sequencing and amino acid microsequencing have all contributed to the formulation of a new synthetic oligonucleotide methodology.


Synthetic Oligonucleotide Euglena Gracilis Probe Probe Transplantation Antigen Synthetic Oligonucleotide Probe 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Antonio A. Reyes
    • 1
  • R. Bruce Wallace
    • 1
  1. 1.Beckman Research Institute of the City of HopeDepartment of Molecular GeneticsDuarteUSA

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