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Rearrangement and Activation of C-MYC Oncogene by Chromosome Translocation in B Cell Neoplasias

  • Kenneth B. Marcu
  • Lawrence W. Stanton
  • Linda J. Harris
  • Rosemary Watt
  • Jian-ging Yang
  • Laurel Eckhardt
  • Barbara Birshtein
  • Elaine Remmers
  • Robert Greenberg
  • Paul Fahrlander
Part of the Genetic Engineering book series (GEPM, volume 6)

Abstract

Specific chromosomal abnormalities have long been associated with various human and murine neoplasias (1–3). The most common chromosome defects consist of band deletions, reciprocal translocations and in some cases trisomy of a specific chromosome (1–3). Until recently, the molecular basis of these chromosomal rearrangements and the significance of their association with specific malignancies remained unknown. Cellular oncogenes (almost invariably found to be homologues of retroviral transforming genes) have been shown to exist in an activated form in a variety of human cancers. In the past year, a number of oncogenes have been localized to specific chromosome bands displaying abnormalities unique to specific neoplasias (2,3).

Keywords

Burkitt Lymphoma Immunoglobulin Heavy Chain Constant Region Aberrant Rearrangement 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Kenneth B. Marcu
    • 1
  • Lawrence W. Stanton
    • 1
  • Linda J. Harris
    • 1
  • Rosemary Watt
    • 2
  • Jian-ging Yang
    • 1
  • Laurel Eckhardt
    • 3
  • Barbara Birshtein
    • 3
  • Elaine Remmers
    • 1
  • Robert Greenberg
    • 1
  • Paul Fahrlander
    • 1
  1. 1.Biochemistry DepartmentState University of New York at Stony BrookStony BrookUSA
  2. 2.Wistar Institute of Anatomy and BiologyPhiladelphiaUSA
  3. 3.Cell Biology DepartmentAlbert Einstein College of MedicineBronxUSA

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