Amino Acid Transport in Isolated Brain Capillaries

  • P. Cardelli-Cangiano
  • C. Cangiano
  • A. Fiori
  • R. Strom


In patients and in experimental animals with severe hepatic failure and/or portal systemic shunting of the circulation, pathologic changes have been described in the transport capacity for neutral amino acids at the level of the blood-brain barrier.


Hepatic Encephalopathy Amino Acid Transport Hydrophobic Amino Acid Neutral Amino Acid Amino Acid Uptake 
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  1. 1.
    A. Cascino, C. Cangiano, F. Fiaccadori, F. Ghinelli, M. Merli, G. Pelosi, O. Riggio, F. Rossi-Fanelli, D. Sacchini, M. Stortoni, and L. Capocaccia, Plasma and cerebrospinal fluid amino acid patterns in hepatic encephalopathy, Dig. Dis. Sci. 27: 828 (1982).PubMedCrossRefGoogle Scholar
  2. 2.
    J. H. James, V. Ziparo, B. Jeppsson, and J. E. Fischer, Hyperammonemia, plasma aminoacid imbalance, and blood-brain aminoacid transport: a unified theory of portal-systemic encephalopathy, Lancet 11: 772 (1979).CrossRefGoogle Scholar
  3. 3.
    J. Ono, D. G. Huston, R. S. Dombro, J. U. Levy, A. Livingstone, and R. Zeppa, Tryptophan and hepatic coma, Gastroenterology 74: 196 (1978).PubMedGoogle Scholar
  4. 4.
    A. R. Smith, F. Rossi-Fanelli, V. Ziparo, J. H. James, B. A. Perrelle, and J. E. Fischer, Alterations in plasma and CSF amino acids,amines and metabolites in hepatic coma, Annals Surg. 187: 343 (1978).CrossRefGoogle Scholar
  5. 5.
    F. Rossi-Fanelli, H. Freund, R. Krause, A. R. Smith, J. H. James, S. Castorina-Ziparo, and J. E. Fischer, Induction of coma in normal dogs by the infusion of aromatic amino acids and its prevention by the addition of branched-chain amino acids, Gastroenterology 83: 664 (1982).PubMedGoogle Scholar
  6. 6.
    H. N. Christensen, M. Liang, and E. G. Archer, A distinct Na+--requiring transport system for alanine, serine, cysteine and similar amino acids, J. Biol. Chem. 242: 5237 (1967).PubMedGoogle Scholar
  7. 7.
    M. S. Kilberg, M. E. Handlogten, and H. N. Christensen, Characteristics of amino acid transport system in rat liver for glutamine, asparagine, histidine, and closely related analogs, J. Biol. Chem. 255 (9): 4011 (1980).PubMedGoogle Scholar
  8. 8.
    G. C. Gazzola, V. Dall’Asta,and G. Guidotti, Adaptive regulation of amino acid transport in cultured human fibroblasts, J. Biol. Chem. 256 (7): 3191 (1981).PubMedGoogle Scholar
  9. 9.
    G. Sessa, M. Orlowsky, and J. P. Green, y-Glutamyl-transpeptidase in brain capillaries: possible site of a blood-brain barrier for amino acids, Science 184: 66 (1974).PubMedCrossRefGoogle Scholar
  10. 10.
    A. L. Betz and G. W. Goldstein, Polarity of the blood-brain barrier: neutral amino acid transport into isolated brain capillaries, Science 202: 225 (1978).PubMedCrossRefGoogle Scholar
  11. 11.
    A. L. Betz, J. Csejtey, and G. W. Goldstein, Hexsose transport and phosphorylation by capillaries isolated from rat brain, Am. J. Physiol. 236: C 96 (1979).Google Scholar
  12. 12.
    H. N. Christensen, On the development of amino acid transport system, Fed. Proc. 32 (1): 19 (1973).PubMedGoogle Scholar
  13. 13.
    P. Cardelli-Cangiano, C. Cangiano, J. H. James, B. Jeppsson, W. Brenner, and J. E. Fischer, Uptake of amino acids by brain microvessels isolated from rat after portacaval anastomosis, J. Neurochem. 36: 627 (1981).PubMedCrossRefGoogle Scholar
  14. 14.
    C. Cangiano, P. Cardelli-Cangiano, J. H. James, and J. E. Fischer, Ammonia stimulates amino acid uptake by isolated bovine brain microvessels, Gastroenterology 78: 1308 (1980).Google Scholar
  15. 15.
    C. Cangiano, P. Cardelli-Cangiano, J. H. James, F. Rossi-Fanelli, M. A. Patrizi, K. A. Brackett, R. Strom, and J. E. Fischer, Brain microvessels take up large neutral amino acids in exchange for glutamine. Cooperative role of Na-dependent and Na-independent systems, J. Biol. Chem. (accepted for publication (1983).Google Scholar
  16. 16.
    L. Zieve and W. M. Doizaki, Brain and blood methanethiol and ammonia concentrations in experimental hepatic coma and coma due to injections of various combinations of these substances, Gastroenterology 79: 2 (1976).Google Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • P. Cardelli-Cangiano
    • 1
  • C. Cangiano
    • 2
  • A. Fiori
    • 1
  • R. Strom
    • 1
  1. 1.Department of BiochemistryUniversity of RomeRomeItaly
  2. 2.3rd Department of Internal MedicineUniversity of RomeRomeItaly

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