Amino Acid Transport in Isolated Brain Capillaries
In patients and in experimental animals with severe hepatic failure and/or portal systemic shunting of the circulation, pathologic changes have been described in the transport capacity for neutral amino acids at the level of the blood-brain barrier.
KeywordsHepatic Encephalopathy Amino Acid Transport Hydrophobic Amino Acid Neutral Amino Acid Amino Acid Uptake
Unable to display preview. Download preview PDF.
- 11.A. L. Betz, J. Csejtey, and G. W. Goldstein, Hexsose transport and phosphorylation by capillaries isolated from rat brain, Am. J. Physiol. 236: C 96 (1979).Google Scholar
- 14.C. Cangiano, P. Cardelli-Cangiano, J. H. James, and J. E. Fischer, Ammonia stimulates amino acid uptake by isolated bovine brain microvessels, Gastroenterology 78: 1308 (1980).Google Scholar
- 15.C. Cangiano, P. Cardelli-Cangiano, J. H. James, F. Rossi-Fanelli, M. A. Patrizi, K. A. Brackett, R. Strom, and J. E. Fischer, Brain microvessels take up large neutral amino acids in exchange for glutamine. Cooperative role of Na-dependent and Na-independent systems, J. Biol. Chem. (accepted for publication (1983).Google Scholar
- 16.L. Zieve and W. M. Doizaki, Brain and blood methanethiol and ammonia concentrations in experimental hepatic coma and coma due to injections of various combinations of these substances, Gastroenterology 79: 2 (1976).Google Scholar