Studies Relating to a Theoretical Understanding of Altered Blood-Brain Barrier Transport in Liver Disease

  • H. J. James
  • B. Jeppsson
  • T. Jonung
  • P. Rigotti
  • J. E. Fischer


Evidence from several sources suggests that blood-brain transport of the large neutral amino acids (NAA) is abnormal in animals with a portacaval anastomosis (PCA) and in patients with liver cirrhosis and portalsystemic shunting. The concentrations in brain of the neutral amino acids methionine, phenylalanine, tyrosine, tryptophan and histidine are markedly elevated in rats after PCA.1–3 The concentrations of many large NAA are elevated several-fold in the cerebrospinal fluid of dogs after PCA and of patients with liver cirrhosis.4,5


Neutral Amino Acid Brain Uptake Large Neutral Amino Acid Neutral Amino Acid Transport Portacaval Anastomosis 


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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • H. J. James
    • 1
  • B. Jeppsson
    • 1
  • T. Jonung
    • 1
  • P. Rigotti
    • 1
  • J. E. Fischer
    • 1
  1. 1.Department of SurgeryUniversity of Cincinnati Medical CenterCincinnatiUSA

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