Studies Relating to a Theoretical Understanding of Altered Blood-Brain Barrier Transport in Liver Disease
Evidence from several sources suggests that blood-brain transport of the large neutral amino acids (NAA) is abnormal in animals with a portacaval anastomosis (PCA) and in patients with liver cirrhosis and portalsystemic shunting. The concentrations in brain of the neutral amino acids methionine, phenylalanine, tyrosine, tryptophan and histidine are markedly elevated in rats after PCA.1–3 The concentrations of many large NAA are elevated several-fold in the cerebrospinal fluid of dogs after PCA and of patients with liver cirrhosis.4,5
KeywordsNeutral Amino Acid Brain Uptake Large Neutral Amino Acid Neutral Amino Acid Transport Portacaval Anastomosis
Unable to display preview. Download preview PDF.
- 3.G. Zanchin, P. Rigotti, N. Dussini, P. Vassanelli,and L. Battistin, Cerebral amino acid levels and uptake in rats after portacaval anastomosis, I. J. Neurosci. Res. 4: 301 (1979).Google Scholar
- 7.G. Zanchin, P. Rigotti, F. Bettineschi, P. Vassanelli,and L. Battistin, Cerebral amino acid levels and uptake in rats after portacaval anastomosis, I. J. Neurosci. Res. 4: 291 (1979).Google Scholar
- 9.J. E. Cremer, J. C. Lal,and G. S. Sarna Rapid blood-brain transport and metabolism of butyrate and pyruvate in the rat after portacaval anastomosis, J. Physiol. (Lond) 266: 70P (1977).Google Scholar
- 18.Z. Gimmon, J. H. James, M. von Mayenfeldt,and J. E. Fischer, Opposing Effects of Prolonged Ammonia and Branched-Chain Amino Acid Infusions on the Accumulation of Aromatic Amino Acids by Brain, in:“Metabolism and Clinical Implications of Branched-Chain Amino and Ketoacids” M. Walser and J. R. Williamson, eds., Elsevier North Holland, New York, pp. 487–492 (1981).Google Scholar