Regional Analysis of Norepinephrine, Dopamine and Amino Acids in the Brain 18 Hours after Hepatectomy and Infusion of Branched-Chain Amino Acids

  • M. Herlin
  • J. H. James
  • C. A. Nachbauer
  • J. E. Fischer


Fulminant hepatic failure is accompanied by an increase of the concentrations of most amino acids in plasma and brain except the branched-chain amino acids.1–4 Norepinephrine (NE) levels in the brain are low in rats with hepatic devascularization5 or hepatectomy6 and in dogs with portacaval shunt and encephalopathy.7 Dopamine (DA), the precursor of NE, has been observed to be near normal in rats with hepatectomy6 and decreased in dogs with portacaval anastomosis7 or in humans with hepatic coma.8


Hepatic Encephalopathy Branch Chain Amino Acid Fulminant Hepatic Failure Neutral Amino Acid Hepatic Coma 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • M. Herlin
    • 1
  • J. H. James
    • 1
  • C. A. Nachbauer
    • 1
  • J. E. Fischer
    • 1
  1. 1.Department of SurgeryUniversity of Cincinnati Medical CenterCincinnatiUSA

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