Lactose to Treat Acute and Chronic Portal Systemic Encephalopathy

  • M. Uribe


The therapeutic effect of the semi-synthetic disaccharide lactulose, in the management of patients with acute and chronic portal systemic encephalopathy (PSE) has been demonstrated in controlled trials.1, 2 However, in developing countries the high cost and unavailability of lactulose constitute a serious drawback. In the majority of developing countries there is a high prevalence of primary lactase malabsorption. Lactose malabsorption ranges from 6% in predominant Caucasian populations to 90–95% in countries with predominantly oriental or black population.3 In Mexico 74% of the people is lactase deficient.


Hepatic Encephalopathy Lactase Deficiency Blood Ammonia Placebo Tablet Lactose Malabsorption 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • M. Uribe
    • 1
  1. 1.Instituto Nacional de la Nutritiòn Salvador ZubirànLiver UnitMexico D.F.Mexico

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