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The Role of Muscle Protein Catabolism in the Plasma Amino Acid Profile of Cirrhotics

  • M. Zoli
  • G. Marchesini
  • G. P. Bianchi
  • C. Dondi
  • A. Melli
  • S. Cassarani
  • V. Bua

Abstract

Patients with liver cirrhosis have peculiar abnormalities in plasma amino acid concentrations: increased aromatic amino acids, methionine and free tryptophan, and decreased branched-chain amino acids.1,2 Increased breakdown of lean body mass was suggested as a mechanism by which aromatic amino acids may accumulate in the general circulation.3 A complete evaluation of myofibrillar protein degradation may be achieved by simultaneous assessment of daily 3-methylhistidine and creatinine in urine.4 In previous studies an increased myofibrillar protein catabolic rate was demonstrated in patients with liver cirrhosis with and without muscle wasting.5

Keywords

Liver Cirrhosis Hepatic Encephalopathy Lean Body Mass Aromatic Amino Acid Muscle Wasting 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • M. Zoli
    • 1
  • G. Marchesini
    • 1
  • G. P. Bianchi
    • 1
  • C. Dondi
    • 1
  • A. Melli
    • 1
  • S. Cassarani
    • 1
  • V. Bua
    • 1
  1. 1.Istituto di Patologia Medica 1Università di BolognaBolognaItaly

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