Brain Gamma Amino-Butyric Acid in Acute Hepatic Encephalopathy in Dogs Following Hepatectomy with or without Abdominal Evisceration
The mechanism of acute hepatic encephalopathy (H.E.) is still unknown. Several hypotheses have been proposed but none of them can explain the entire clinical and biochemical picture.1 The present study was designed to evaluate the gamma aminobutyric acid (GABA) neuroinhibitory system in acute HE following hepatectomy in dogs; indeed, several features of HE are quite similar to coma produced by substances like barbiturates and benzodiazepines which enhance the GABA ergic system. Since the enteric flora is supposed to synthesize GABA, we also examined the effect of abdominal evisceration on acute HE induced by hepatectomy.
KeywordsHepatic Encephalopathy Hepatic Coma Brain Energy Metabolism Brain Gaba Plasma Glutamine Level
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