Plasma Influence on the Altered Blood-Brain Barrier to Amino Acids after Portacaval Shunt: Preliminary Results
The increased cerebral levels of aromatic amino acids are likely to play an important role on the pathogenesis of hepatic encephalopathy.5 Liver impairment is accompanied with changes in the levels of neurotransmitters,6 possibly consequent to the high brain concentrations of their precursors amino acids: brain serotonin is elevated, due to high cerebral levels of tryptophan;4,14 the false neurotransmitters phenylethanolamine and octopamine are increased, probably because the raised cerebral levels of tyrosine and phenylalanine partially divert the cathecolamine synthesis pathway. 7,15
KeywordsPermeability Tyrosine Serotonin Glutamine Lalanine
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