Plasma Influence on the Altered Blood-Brain Barrier to Amino Acids after Portacaval Shunt: Preliminary Results
The increased cerebral levels of aromatic amino acids are likely to play an important role on the pathogenesis of hepatic encephalopathy.5 Liver impairment is accompanied with changes in the levels of neurotransmitters,6 possibly consequent to the high brain concentrations of their precursors amino acids: brain serotonin is elevated, due to high cerebral levels of tryptophan;4,14 the false neurotransmitters phenylethanolamine and octopamine are increased, probably because the raised cerebral levels of tyrosine and phenylalanine partially divert the cathecolamine synthesis pathway. 7,15
KeywordsHepatic Encephalopathy Neutral Amino Acid Tritiated Water PORTACAVAL Shunt Portocaval Shunt
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- 1.R. J. Baldessarini and J. E. Fischer, Substitute and alternative neurotransmitters in neuropsychiatric illness, Arch. Gen. Psychiat. 34: 958 (1977).Google Scholar
- 5.J. F. Fischer, J. M. Funovics, A. Aguirre, J. H. James, J. M. Keane, R. I. C. Wesdorp, N. Yoshimura,and T. Westman, The role of plasma amino acids in hepatic encephalopathy, Surgery 78: 276 (1975).Google Scholar
- 17.G. Zanchin, P. Rigotti, P. Vassanelli, and L. Battistin, Blood-brain barrier after portocaval shunt (PCS) in the rat: plasma influence on the altered amino acid transport. 9th International Congress of Neuropathology (abstracts). Vienna (1982).Google Scholar