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Chromium

  • Chapter
Book cover Biochemistry of the Essential Ultratrace Elements

Part of the book series: Biochemistry of the Elements ((BOTE,volume 3))

Abstract

Chromium is an essential element for animals and humans. Insufficient dietary chromium leads to signs and symptoms similar to those associated with diabetes and/or cardiovascular diseases. The dietary chromium intake of normal individuals is often less than the suggested mimimum intake. Children with protein-calorie malnutrition, diabetics, and elderly and middle-aged subjects have all been shown to respond to supplemental Cr. Dietary trends such as consuming more highly processed foods that are often not only low in Cr but also stimulate increased losses of body Cr stores may exacerbate existing problems associated with marginal dietary intake of chromium by humans.

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References

  • Abraham, A. S., Sonnenblick, M., Eini, M., Shemash, O., Batt, A. P., 1980. The effect of chromium on established atherosclerotic plaques in rabbits, Am. J. Clin. Nutr. 33: 2294–2298.

    Google Scholar 

  • Abraham, A. S., Sonnenblick, M., Eini, M., 1982. The action of chromium on serum lipids and on atherosclerosis in cholesterol-fed rabbits, Atherosclerosis 42: 185–195.

    Article  PubMed  CAS  Google Scholar 

  • American Medical Association Department of Foods and Nutrition, 1979. Guidelines for essential trace element preparations for parenteral use. A statement by an expert panel, J. Am. Med. Assoc. 241: 2051–2054.

    Google Scholar 

  • Anderson, R. A., 1981a. Nutritional role of chromium, Sci. Total Environ. 17: 13–29.

    Google Scholar 

  • Anderson, R. A., 1981b. Chromium as a naturally occurring chemical in humans. Proceedings of Chromate Symposium-80, Industrial Health Foundation, Inc., Pittsburgh, pp. 332–345.

    Google Scholar 

  • Anderson, R. A., Bryden, N. A., 1983. Concentration, insulin potentiation and absorption of chromium in beer, J. Agric. Food Chem. 31: 308–311.

    Google Scholar 

  • Anderson, R. A., Polansky, M. M., 1981. Dietary chromium deficiency: Effect on sperm count and fertility in rats, Biol. Trace Element Res. 3: 1–5.

    Google Scholar 

  • Anderson, R. A., Brantner, J. H., Polansky, M. M., 1978. An improved assay for biologically active chromium, J. Agric. Food Chem. 26: 1219–1221.

    Google Scholar 

  • Anderson, R. A., Polansky, M. M., Bryden, N. A., Roginski, E. E., Patterson, K. Y., Veillon, C., Glinsmann, W., 1982a. Urinary chromium excretion of human subjects: Effect of chromium supplementation and glucose loading, Am. J. Clin. Nutr. 36: 1184–1193.

    Google Scholar 

  • Anderson, R. A., Polansky, M. M., Bryden, N. A., Roginski, E. E., Patterson, K. Y., Reamer, D. C., 1982b. Effects of exercise (running) on serum glucose, insulin, glucagon, and chromium excretion, Diabetes 31: 212–216.

    Article  PubMed  CAS  Google Scholar 

  • Anderson, R. A., Polansky, M. M., Bryden, N. A., Patterson, K. Y., Veillon, C., Glinsmann, W. A., 1983a. Effect of chromium supplementation on urinary Cr excretion of human subjects and correlation of Cr excretion with selected clinical parameters, J. Nutr. 113: 276–281.

    PubMed  CAS  Google Scholar 

  • Anderson, R. A., Polansky, M. M., Bryden, N. A., Roginski, E. E., Mertz, W., Glinsmann, W., 1983b. Chromium supplementation of human subjects: Effects on glucose, insulin and lipid parameters, Metabolism. 32: 894–899.

    Google Scholar 

  • Borel, J. S., Majerus, T. C., Polansky, M. M., Moser, P. B., Anderson, R. A., 1983, Chromium intake and urinary chromium excretion of trauma patients, Fed. Proc. 42: 925.

    Google Scholar 

  • Carter, J. P., Kattab, A., Abd-El-Hadi, K., Davis, J., El Gholmy, A., Patwardhan, V. N., 1968. Chromium(III) in hypoglycemia and in impaired glucose utilization in kwashiorkor, Am. J. Clin. Nutr. 21: 195–202.

    Google Scholar 

  • Chen, N. S. C., Tsai, A., Dyer, I. A., 1973. Effect of chelating agents on chromium absorption in rats, J. Nutr. 103: 1182–1186.

    PubMed  CAS  Google Scholar 

  • Collins, R. J., Fromin, P. O., Collings, W. D., 1961. Chromium excretion in the dog, Am. J. Physiol. 201: 795–798.

    Google Scholar 

  • Cote, M., Munan, L., Gagne-Billon, M., Kelly, A., Di Pietro, O., Shapcott, D., 1979, Hair chromium concentration and arteriosclerotic heart disease, in Chromium in Nutrition and Metabolism, D. Shapcott and J. Hubert (eds.), Elsevier/North-Holland, Amsterdam, pp. 223–228.

    Google Scholar 

  • Davidson, I. W. F., Burt, R. L., 1973, Physiologic changes in plasma chromium of normal and pregnant women: Effect of a glucose load, Am. J. Obstet. Gynecol. 116: 601–608.

    Google Scholar 

  • Davidson, I. W. F., Burt, R. L., Parker, J. C., 1974. Renal excretion of trace elements; Chromium and copper, Proc. Soc. Exp. Biol. Med. 147: 720–725.

    Google Scholar 

  • Doisy, R. J., Streeten, D. H. P., Souma, M. L., Kalafer, M. E., Rekant, S. L., Dalakos, T. G., 1971. Metabolism of chromium 51 in human subjects, in Newer Trace Element in Nutrition, W. Mertz and W. E. Cornatzer (eds.), Dekker, New York, pp. 155–168.

    Google Scholar 

  • Doisy, R. J., Straeten, D. H. P., Freiberg, J. M., Schneider, A. J., 1976. Chromium metabolism in man and biochemical effects, in Trace Elements in Human Health and Disease, Vol. II, Essential and Toxic Elements, A. S. Prasad and D. Oberleas (eds.), Academic Press, New York, pp. 79–104.

    Google Scholar 

  • Donaldson, D. L., Anderson, R. A., Veillon, C., Mertz, W. E., 1982. Renal excretion of orally and parenterally administered chromium-51, Fed. Proc. 41: 391. (Abstract.)

    Google Scholar 

  • Eatough, D. J., Hansen, L. O., Starr, S. E., Astin, M. S., Larsen, S. B., Izatt, R. M., Christensen, J. J., 1978. Chromium in autopsy tissues of diabetic and non-diabetic American (Pima) Indians, in Trace Element Metabolism in Man and Animals, Vol. HI, M. Kirchgessner (ed.), Institut fur Ernahrungspysislogie, Freising-Weihenstephan, pp. 259–263.

    Google Scholar 

  • Fell, G. S., Halls, D., Shenkin, A., 1979. Chromium requirements during intravenous nutrition, in Chromium in Nutrition and Metabolism, D. Shapcott, J. Hubert (eds.) Elsevier/North Holland, Amsterdam, pp. 105–112.

    Google Scholar 

  • Freund, H., Atamian, S., Fischer, J. E., 1979, Chromium deficiency during total parenteral nutrition, J. Am. Med. Assoc. 241: 496–498.

    Google Scholar 

  • Glinsmann, W. H. Mertz, W., 1966. Effect of trivalent chromium on glucose tolerance, Metabolism 15: 510–520.

    CAS  Google Scholar 

  • Glinsmann, W. H., Feldman, F. J., Mertz, W., 1966. Plasma chromium after glucose admin-istration, Science 152: 1243–1245.

    Article  PubMed  CAS  Google Scholar 

  • Gurson, C. T. Saner, G., 1971. Effect of chromium on glucose utilization in marasmic protein- calorie malnutrition, Am. J. Clin. Nutr. 24: 1313–1319.

    Google Scholar 

  • Gurson, C. T., Saner, G., 1978. The effect of glucose loading on urinary excretion of chromium in normal adults, in individuals from diabetic families and in diabetics, Am. J. Clin. Nutr. 31: 1158–1161.

    Google Scholar 

  • Gurson, C. T., Saner, G., 1971. Effect of chromium on glucose utilization in marasmic protein calorie malnutrition, Am. J. Clin. Nutr. 24: 1313–1316.

    Google Scholar 

  • Gurson, C. T., Saner, G., Mertz, W., Wolf, W. R., Sokucu, S., 1975. Nutritional significance of chromium in different chronological age groups and in populations differing in nutritional backgrounds, Nutr. Rep. Int. 12: 9–17.

    Google Scholar 

  • Hahn, C. J., Evans, G. W., 1975. Absorption of trace metals in the zinc-deficient rat, Am. J. Physiol. 228: 1020–1023.

    Google Scholar 

  • Hambidge, K. M., 1971. Chromium nutrition in the mother and the growing child, in Newer Trace Elements in Nutrition, W. Mertz and W. E. Cornatzer (eds.), Dekker, New York, pp. 169–194.

    Google Scholar 

  • Hambidge, K. M., Franklin, M. L., Jacobs, M. A., 1972. Hair chromium concentration: Effect of sample washing and external environment, Am. J. Clin. Nutr. 25: 384–389.

    Google Scholar 

  • Hauer, E. C., Kaminski, M. V., 1978. Trace metal profile of parenteral nutrition solutions, Am. J. Clin. Nutr. 31: 264–268.

    Google Scholar 

  • Hill, C. H., 1975. Mineral interrelationships, in Trace Elements and Human Disease, Vol. 2, A. S. Prasad (ed.), Academic Press, New York, pp. 281–300.

    Google Scholar 

  • Hopkins, L. L., Jr., 1965. Distribution in the rat of physiological amounts of injected Cr51 ( III) with time, Am. J. Physiol. 209: 731–735.

    Google Scholar 

  • Hopkins, L. L., Jr., Schwarz, K., 1964. Chromium(III) binding to serum proteins, specifically siderophilin, Biochem. Biophys. Acta 90: 484-491.

    Google Scholar 

  • Hopkins, L. L., Jr., Ransome-Kuti, O., Majaj, A. S., 1968. Improvement of impaired carbohydrate metabolism by chromium(III) in malnourished infants, Am. J. Clin. Nutr. 21: 203–211.

    Google Scholar 

  • Jain, R., Verch, R. L., Wallach, S., Peabody, R. A., 1981. Tissue chromium exchange in the rat, Am. J. Clin. Nutr. 34: 2199–2204.

    Google Scholar 

  • Jeejeebhoy, K. N., Chu, R. C., Marliss, E. B., Greenberg, G. R., Bruce-Robertson, A., 1977, Chromium deficiency, glucose intolerance, and neuropathy reversed by chromium supplementation in a patient receiving long-term total parenteral nutrition, Am. J. Clin. Nutr. 30: 531–538.

    PubMed  CAS  Google Scholar 

  • Kayne, F. I., Komar, G., Laboda, H., Vanderlinde, R. E., 1978. Atomic absorption spectrophotometry of chromium in serum and urine with a modified Perkin-Elmer 603 atomic absorption spectrophotometer, Clin. Chem. 24: 2151–2154.

    PubMed  CAS  Google Scholar 

  • Koivistoinen, P. (ed.), 1980. Mineral element composition of Finnish foods: N, K, Ca, Mg, P, S, Fe, Cu, Mn, Zn, Mo, Co, Ni, Cr, F, Se, Si, Rb, Al, B, Br, Hg, As, Cd, Pb and Ash, Acta Agric. Scand., Suppl. 22, Stockholm.

    Google Scholar 

  • Kraintz, L., Talmage, R. V., 1952. Distribution of radioactivity following intravenous administration of trivalent chromium51 in the rat and rabbit, Proc. Soc. Exp. Biol. Med. 81: 490–492.

    PubMed  CAS  Google Scholar 

  • Kumpulainen, J. T., Wolf, W. R., Veillon, C., Mertz, W., 1979. Determination of chromium in selected United States diets, J. Agric. Food Chem. 27: 490–494.

    Article  PubMed  CAS  Google Scholar 

  • Langard, S., 1980. Chromium, in Metals in the Environment, H. H. Waldron (ed.), Academic Press, London, pp. 111–132.

    Google Scholar 

  • Levine, R. A., Streeten, D. H. P., Doisy, R. J., 1968. Effects of oral chromium supplementation on the glucose tolerance of elderly subjects, Metabolism 17: 114–125.

    Article  PubMed  CAS  Google Scholar 

  • Liu, V. J. K., Morris, J., 1978. Relative chromium response as an indicator of chromium status, Am. J. Clin. Nutr. 31: 972–976.

    PubMed  CAS  Google Scholar 

  • Mahalko, J. R., Bennion, M., 1976. The effect of parity and time between pregnancies on maternal hair chromium concentration, Am. J. Clin. Nutr. 29: 1069 - 1072.

    PubMed  CAS  Google Scholar 

  • Mathur, R. K., Doisy, R. J., 1972. Effect of diabetes and diet on the distribution of tracer doses of chromium in rats, Proc. Soc. Exp. Biol. Med. 139: 836–838.

    PubMed  CAS  Google Scholar 

  • Mertz, W., 1969. Chromium occurrence and function in biological systems, Physiol. Rev. 49: 163–239.

    PubMed  CAS  Google Scholar 

  • Mertz, W., Roginski, E. E., 1969. Effects of chromium(III) supplementation on growth and survival under stress in rats fed low protein diets, J. Nutr. 97: 513–536.

    Google Scholar 

  • Mertz, W., Roginski, E. E., 1971. Chromium metabolism: The glucose tolerance factor, in Newer Trace Elements in Nutrition, W. Mertz and W. E. Coraatzer (eds.), Dekker, New York, pp. 123–153.

    Google Scholar 

  • Mertz, W., Roginski, E. E., Schwarz, K., 1961. Effect of trivalent chromium complexes on glucose uptake by epididymal fat tissue of rats, J. Biol. Chem. 236: 318–322.

    PubMed  CAS  Google Scholar 

  • Mertz, W., Roginski, E. E., Reba, R. C., 1965. Biological activity and fate of trace quantities of intravenous chromium(III) in the rat, Am. J. Physiol. 209: 489–494.

    PubMed  CAS  Google Scholar 

  • Morgan, J. M., 1972. Hepatic chromium content of diabetic subjects, Metab. Clin. Exp. 21: 313–316.

    Article  PubMed  CAS  Google Scholar 

  • Nath, R., Minocha, J., Lyall, V., Sunder, S., Kumar, V. Kapoor, S., Dhar, K. L., 1979. Assessment of chromium metabolism in maturity onset and juvenile diabetes using chromium- 51 and therapeutic response of chromium administration on plasma lipids, glucose tolerance and insulin levels, in Chromium in Nutrition and Metabolism, D. Shapcott and J. Hubert (eds.), Elsevier/North Holland, Amsterdam, pp. 213–222.

    Google Scholar 

  • National Research Council, 1974. Medical and Biological Effects of Environmental Pollutants: Chromium, National Academy of Sciences, Washington, D.C.

    Google Scholar 

  • National Research Council, 1980. Recommended Dietary Allowances, National Academy of Sciences, Washington, D.C.

    Google Scholar 

  • Newman, H. A. I., Leighton, R. F., Lanese, R. R., and Freedland, N. A., 1978. Serum chromium and angiographically determined coronary artery disease, Clin. Chem. 24: 541–544.

    PubMed  CAS  Google Scholar 

  • Offenbacher, E. G., Pi-Sunyer, F. X., 1980. Beneficial effect of chromium-rich yeast on glucose tolerance and blood lipids in elderly subjects, Diabetes 29: 919–925.

    Article  PubMed  CAS  Google Scholar 

  • Offenbacher, E. G., Pi-Sunyer, F. X., 1983. Temperature and pH effects on the release of chromium from stainless steel into water and fruit juices, J. Agric. Food Chem. 31: 89–92.

    Article  PubMed  CAS  Google Scholar 

  • Okada, S., Hiroshi, O., Taniyama, M., 1981. Alterations in ribonucleic acid synthesis by chromium(III), J. Inorg. Biochem 15: 223–331.

    Google Scholar 

  • Onkelinz, C., 1977. Compartment analysis of metabolism of chromium(III) in rats of various ages, Am. J. Physiol.: Endocrinol. Metab. Gastrointest. Physiol. 1: E478–E484.

    Google Scholar 

  • Pekarek, R. S., Hauer, E. C., Rayfield, E. J., Wannemacher, R. W., Beisel, W. R., 1975. Relationship between serum chromium concentrations and glucose utilization in normal and infected subjects, Diabetes 24: 340–353.

    Article  Google Scholar 

  • Potter, J. F., Levin, P., Anderson, R. A., Freiberg, J. M., Andres, R., Elahi, D., 1983. Glucose metabolism in glucose intolerant older people during chromium supplementation, Metabolism. Submitted.

    Google Scholar 

  • Rabinowitz, M. B., Levin, S. R., and Gonick, H. C., 1980. Comparisons of chromium status in diabetic and normal men, Metabolism 29: 355–364.

    Article  PubMed  CAS  Google Scholar 

  • Riales, R., and Albrink, M. J., 1981. Effect of chromium chloride supplementation on glucose tolerance and serum lipids including high-density lipoprotein of adult men. Am. J. Clin. Nutr. 34: 2670–2678.

    Google Scholar 

  • Roginski, E. E., Mertz, W., 1969. Effects of chromium supplementation on glucose and amino acid metabolism in rats fed a low protein diet, J. Nutr. 97: 525–530.

    PubMed  CAS  Google Scholar 

  • Rollinson, C. L., Rosenbloom, E., Lindsay, L., 1967, Reactions of chromium(III) with biological substances, in Proc. 7th International Congress of Nutrition, Vol. 5, Pegamon, New York, pp. 692–698.

    Google Scholar 

  • Rosson, J. W., Foster, K. J., Walton, R. J., Monro, P. P., Taylor, T. G., Alberti, K. G. M. M., 1979. Hair chromium concentrations in adult insulin-treated diabetics, Clin. Chim. Acta 93: 299–304.

    Google Scholar 

  • Sargent, T., Lim, T. H., Jensen, R. L., 1979. Reduced chromium retention in patients with hemochromatosis, a possible basis of hemochromatotic diabetes, Metabolism 28: 70–79.

    Article  PubMed  Google Scholar 

  • Schroeder, H. A., 1965. Serum cholesterol levels in rats fed thirteen trace elements, J. Nutr. 94: 475–480.

    Google Scholar 

  • Schroeder, H. A., 1968. The role of chromium in mammalian nutrition, Am. J. Clin. Nutr. 21: 230–244.

    Google Scholar 

  • Schroeder, H. A., 1970. Chromium Air Quality Monograph, #70-15, American Petroleum Institute, Washington, D.C., 28 pp.

    Google Scholar 

  • Schroeder, H. A., Balassa, J. J., Tipton, I. H., 1962. Abnormal trace metals in man—chromium, J. Chronic Dis. 15: 941–964.

    Article  PubMed  CAS  Google Scholar 

  • Schroeder, H. A., Nason, A. P., Tipton, I. H., 1970. Chromium deficiency as a factor in atherosclerosis, J. Chronic Dis. 23: 123–142.

    Article  PubMed  CAS  Google Scholar 

  • Schwarz, K. Mertz, W., 1957. A glucose tolerance factor and its differentiation from factor 3, Arch. Biochem. Biophys. 72: 515–518.

    Google Scholar 

  • Seeling, W., Ahnefeld, F. W., Grunert, A., Kienle, K. H., Swobodnik, M., 1979. Chromium in parenteral nutrition, in Chromium in Nutrition and Metabolism, D. Shapcott and J. Hubert (eds.), Elsevier/North Holland, Amsterdam, pp. 95–104.

    Google Scholar 

  • Stout, R. W., 1977. The relationship of abnormal circulating insulin levels to atherosclerosis, A therosclerosis 27: 1–13.

    Article  CAS  Google Scholar 

  • Toepfer, E. W., Mertz, W., Roginski, E. E., Polansky, M. M., 1973. Chromium in foods in relation to biological activity, J. Agric. Food. Chem. 21: 69–73.

    Google Scholar 

  • Toepfer, E. W., Mertz, W., Polansky, M., Roginski, E. E., Wolf, W. R., 1977. Preparation of chromium-containing material of glucose tolerance factor activity from brewer’s yeast extracts and by synthesis, J. Agric. Food Chem. 25: 162–166.

    Google Scholar 

  • Towill, L. E., Shriner, C. R., Drury, J. S., Hammons, A. S., Holleman, J. W., 1978. Reviews of the environmental effects of pollutants: III. Chromium. Oak Ridge National Laboratory and U.S. Environmental Protection Agency, Cincinnati, Ohio.

    Google Scholar 

  • Tuman, R. W., Bilbo, J. T., Doisy, R. J., 1978. Comparison and effects of natural and synthetic glucose tolerance factor in normal and genetically diabetic mice, Diabetes 27: 49–56

    PubMed  CAS  Google Scholar 

  • Vanderlinde, R. E., Kayne, F. J., Komar, G., Simmons, M. J., Tsou, J. Y., Lavine, R. L., 1979. Serum and urine levels of chromium, in Chromium in Nutrition and Metabolism, D. Shapcott and J. Hubert (eds.), Elsevier/North-Holland, Amsterdam, pp. 49–57.

    Google Scholar 

  • Veillon, C., Patterson, K. Y., Bryden, N. A., 1982. Direct determination of chromium in human urine by electrothermal atomic absorption spectrometry, Anal. Chim. Acta. 136: 233–241.

    Google Scholar 

  • Versieck, J., de Rudder, J., Hoste, J., Barbier, F., Lemey, G., Vanballenberghe, L., 1979. Determination of the serum chromium concentration in healthy individuals by neutron activation analysis, in Chromium in Nutrition and Metabolism, D. Shapcott and J. Hubert (eds.), Elsevier/North-Holland, Amsterdam, pp. 49–57.

    Google Scholar 

  • Visek, W. J., Whitney, I. B., Kuhn, U. S. G., III, Comar, C. L., 1953. Metabolism of Cr51 by animals as influenced by chemical state, Proc. Soc. Exp. Biol. Med. 84: 610–615.

    Google Scholar 

  • Vittorio, P. V., Wight, E. W., Sinnott, B. E.. 1962, The distribution of chromium-51 in mice after intraperitoneal injection, Can. J. Biochem. Physiol. 40: 1677–1683.

    Google Scholar 

  • Wolf, W., Mertz, W., Masironi, R., 1974. Determination of chromium in refined and unrefined sugars by oxygen plasma ashing flameless atomic absorption, J. Agr. Food Chem. 22: 1037–1042.

    Google Scholar 

  • Wu, G. Y., Wada, O., 1981. Studies on a specific chromium binding substance (a low molecular weight chromium binding substance) in urine, Jpn. J. Ind. Health, 23: 505–512.

    Google Scholar 

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  1. Beltsville Human Nutrition Research Center, U.S. Department of Agriculture, Beltsville, Maryland, 20705, USA

    Janet S. Borel & Richard A. Anderson

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  1. Janet S. Borel
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  1. The Florida State University, Tallahasse, Florida, USA

    Earl Frieden

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Borel, J.S., Anderson, R.A. (1984). Chromium. In: Frieden, E. (eds) Biochemistry of the Essential Ultratrace Elements. Biochemistry of the Elements, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4775-0_8

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  • DOI: https://doi.org/10.1007/978-1-4684-4775-0_8

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