Responses to Epstein-Barr Virus in Immune Deficient Patients

  • Shinji Harada
  • Eiji Tatsumi
  • Helen Lipscomb
  • David T. Purtilo


Two decades have passed since Epstein-Barr virus (EBV) was described (1) and yet new diseases continue to be attributed to the virus. Debates initiated in the early 1960’s are ongoing regarding the role of the virus in Burkitt lymphoma (BL), and nasopharyngeal carcinoma (NPC). Recently, the opportunistic malignant lymphomas (ML) occurring in immune deficient individuals have provided new puzzles. Questions remaining to be answered are whether latent virus is activated in B cells transformed by other agents or alternatively, does the virus infect the malignant B cell after transformation owing to the presence of viral receptors on the cell. Attention has also been directed to find oncogenic and benign strains of the virus. In our view, underlying inherited or environmentally induced immune deficiency is important in determining the outcome of EBV infections.


Immune Deficiency Natural Killer Cell Activity Burkitt Lymphoma Infectious Mononucleosis Primary Immunodeficiency Disease 
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Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • Shinji Harada
    • 1
  • Eiji Tatsumi
    • 1
  • Helen Lipscomb
    • 1
  • David T. Purtilo
    • 1
  1. 1.Department of Pathology & Laboratory MedicineUniversity of Nebraska Medical CenterOmahaUSA

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