Abstract
Two decades have passed since Epstein-Barr virus (EBV) was described (1) and yet new diseases continue to be attributed to the virus. Debates initiated in the early 1960’s are ongoing regarding the role of the virus in Burkitt lymphoma (BL), and nasopharyngeal carcinoma (NPC). Recently, the opportunistic malignant lymphomas (ML) occurring in immune deficient individuals have provided new puzzles. Questions remaining to be answered are whether latent virus is activated in B cells transformed by other agents or alternatively, does the virus infect the malignant B cell after transformation owing to the presence of viral receptors on the cell. Attention has also been directed to find oncogenic and benign strains of the virus. In our view, underlying inherited or environmentally induced immune deficiency is important in determining the outcome of EBV infections.
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References
Epstein, M.A., Achong, B.G., and Barr, Y.M. Virus particles in cultured lymphoblasts from Burkitt’s Lymphoma. Lancet, i:702–703, 1964.
Purtilo, D.T. X-linked lymphoproliferative syndrome: an immunodeficiency disorder with acquired agammaglobulinemia, fatal infectious mononucleosis or malignant lymphoma. Arch. Path. Lab. Med., 106:119, 1981.
Henle, W., Henle, G., and Lennette, E.T. Epstein-Barr virus. Sci. Am., 241:48, 1979.
Niederman, J.C. Prevalence, incidence and persistence of EB virus antibody in young adults. N. Engl. J. Med., 282:361, 1970.
Tosato, G., Magrath, I., Koski, I., Dooley, N., and Blaese, M. Activation of suppressor T cells during Epstein-Barr-virus-induced infectious mononucleosis. N. Engl. J. Med., 301:1133, 1979.
Klein, G., Svedmyr, E., Jondal, M., and Persson, P.O. EBV-determined nuclear antigen (EBNA)-positive cells in the peripheral blood of infectious mononucleosis patients. Int. J. Cancer, 17:21, 1976.
Robinson, J.E., Smith, D., and Niederman, J. Plasmacytic differentiation of circulating Epstein-Barr virus-infected B lymphocytes during acute infectious mononucleosis. J. Exp. Med., 153:235, 1980.
Epstein-Barr Virus. Editors, M.A. Epstein and B. Achong, Springer-Verlag, Berlin, 1979.
Purtilo, D.T. Immunopathology of infectious mononucleosis and other complications of Epstein-Barr virus infections. In: S.C. Sommers and P.P. Rosen (eds.), Pathology Annual, 1980. pp. 253–299. New York: Appleton-Century-Crofts, 1980.
Purtilo, D.T., DeFlorio, D., Hutt, L.M., Bhawan, J., Yang, J.P.S., Otto, R., and Edwards, W. Variable phenotypic expression of an X-linked recessive lymphoproliferative syndrome. N. Engl. J. Med., 297:1077, 1977.
Purtilo, D.T., Paquin, L.A., DeFlorio, D., Virzi, F., and Sukhuja, R. Immunodiagnosis and immunopathogenesis of the X-linked recessive lymphoproliferative syndrome. Sem. Hematol. 16:309, 1979.
Purtilo, D.T. Hypothesis: pathogenesis and phenotypes of an X-linked recessive lymphoproliferative syndrome. Lancet, ii:882, 1976.
Purtilo, D.T., Sakamoto, K., Barnabei, V., Seeley, J., Bechtold, T., Rogers, G., Yetz, J., and Harada, S. Epstein-Barr virus-induced diseases in males with the X-linked lymphoproliferative syndrome (XLP). Am. J. Med., 73: 49, 1982.
Purtilo, D.T., Sakamoto, K., Saemundsen, A.K., Sullivan, J.L., Synnerholm, A.C., Andersson-Anvret, M., Pritchard, J., Sloper, C., Sieff, Collins, R., Barnes, N., Knight, J., Sandstedt, B., and Klein, G. Documentation of Epstein-Barr virus infection in immunodeficient patients with life-threatening lymphoproliferative disease by clinical, virological and immunopathological studies. Cancer Res., 41:4226, 1981.
Saemundsen, A.K., Purtilo, D.T., Sakamoto, K., Sullivan, J.L., Synnerholm, A.C., Hanto, D., Simmons, R., Anvret, M., Collins, R., and Klein, G. Documentation of Epstein-Barr virus infection in immunodeficient patients with life-threatening lymphoproliferative diseases by Epstein-Barr virus complementary RNA/DNA and viral DNA/DNA hybridization. Cancer Res., 41:4237, 1981.
Seeley, J.K., Sakamoto, K., Ip, S., Hansen, P., and Purtilo, D.T. Abnormal subsets in the X-linked lymphoproliferative syndrome. J. Immunol., 127:2618, 1981.
Purtilo, D.T., Yang, J.P.S., Cassel, C.K., Harper, P., Stephenson, S.R., Landing, B.H. and Vawter, G.F. X-linked recessive progressive combined variable immunodeficiency (Duncan’s disease). Lancet, i: 935, 1975.
Lindsten, T., Seeley, J.K., Sakamoto, K., Yetz, J., Harada, S., Bechtold, T., Rogers, G., and Purtilo, D.T. Immune deficiency in the X-linked lymphoproliferative syndrome. II. Immunoregulatory T cell defects. J. Immunol., 129:2536, 1982.
Ochs, H.D., Sullivan, J.L., Wedgewood, R.J., Seeley, J.K., Sakamoto, K., and Purtilo, D.T. X-linked lymphoprolifer-ative syndrome: abnormal antibody responses to bacteriophage ØX174. In: R. Wedgewood and F. Rosen (eds.), Primary Immunodeficiency Diseases. New York: Alan R Liss, 1983.
Seeley, J.K., Harada, S., Bechtold, T., Ochs, H.D., Wedgewood, R.J., Sakamoto, K., Lindsten, T., Yetz, J., and Purtilo, D.T. Primary and acquired immune defects in X-linked lymphoproliferative syndrome. In preparation.
Harada, S., Bechtold, T., and Purtilo, D.T. Comparison of long-term T-cell-mediated immunity to Epstein-Barr virus and NK cell-activity in obligate carrier females and males with the X-linked lymphoproliferative syndrome. Int. J. Cancer, 216:739, 1982.
Szigeti, R., Masucci, M.G., Henle, W., Henle, G, Purtilo, D.T., and Klein, G. Effects of different EBV-determined antigens (EBNA, EA and VCA) on mononucleosis and certain immunodeficiencies. Clin. Immunol. Immunopath., 22:128, 1982.
Sullivan, J.L., Byron, K., Brewster, F., and Purtilo, D.T. Deficient natural killer cell activity in the X-linked lymphoproliferative syndrome. Science, 210:543, 1981.
Purtilo, D.T. Immune deficiency predisposing to Epstein-Barr virus-induced lymphoproliferative diseases: the X-linked lymphoproliferative syndrome as a model. In: G. Klein and S. Weinhouse (eds.), Advances in Cancer Research. Vol. 34, pp. 279–312. New York: Academic Press, 1980.
Sakamoto, K., Freed, H., and Purtilo, D.T. Antibody re sponses to Epstein-Barr virus in families with the X-linked lymphoproliferative syndrome. J. Immunol., 125:921, 1980.
Sakamoto, K., Seeley, J.K., Lindsten, T., Sexton, J., Yetz, J., Ballow, M., and Purtilo, D.T. Abnormal anti-Epstein-Barr virus antibodies in carriers of the X-linked lymphoproliferative syndrome and in females at risk. J. Immunol., 128:904, 1982.
Seeley, J.K., Bechtold, T., Lindsten, T., and Purtilo, D.T. NK deficiency in X-linked lymphoproliferative syndrome. In: R.B. Herberman (ed.), Natural Cell Mediated Immunity 1982. Vol. 2, pp. 1211–1218. New York: Academic Press, 1982.
Rickinson, A.B., Moss, D.J., Wallace, L.E., Rowe, M., Misko, I.S., Epstein, M.A., and Pope, J.H. Long-term T-cell-mediated immunity to Epstein-Barr virus. Cancer Res., 41:4216, 1981.
Purtilo, D.T. and Sullivan, J.L. Immunological bases for superior survival of females. Am. J. Dis. Child., 133:1251, 1979.
Klein, G. Lymphoma development in mice and humans: diversity of initiation is followed by convergent cytogenetic evolution. Proc. Natl. Acad. Sci., 76: 2442, 1979.
Rowley, J.D. Identification of the constant chromosome regions involved in human hematologic malignant disease. Science, 216: 794, 1982.
Kersey, J.H. and Spector, B.D. Immune deficiency disease. In: J. F. Fraumeni, Jr. (ed.), Persons at High Risk of Cancer: An Approach to Cancer Etiology and Control, pp. 55–67. New York: Academic Press, 1975.
Saemundsen, A.K. Epstein-Barr virus-carrying lymphoma in a patient with ataxia-telangiectasia. Brit. Med. J., 282:425, 1981.
Purtilo, D.T., Liao, S.A., Sakamoto, K., Snyder, L.M., DeFlorio, D., Bhawan, J., Paquin, L.A., Yang, J.P.S., Hutt-Fletcher, L.M., Muralidharan, K., Raffa, P., Saemundsen, A.K., and Klein, G. Diverse familial malignant tumors and Epstein-Barr virus. Cancer Res., 41:4248, 1981.
Penn, I. Depressed immunity and the development of cancer. Clin. Exp. Immunol., 46:459–474, 1981.
Hanto, D.W., Frizzera, G., Purtilo, D.T., Sakamoto, K., Sullivan, J.L., Saemundsen, A.K., Klein, G., Simmons, R.L., and Najarian, J.S. Clinical spectrum of lymphoproliferative disorders in renal transplant recipients and evidence for the role of Epstein-Barr virus. Cancer Res., 41:4253, 1981.
Hanto, D.W., Frizzera, G., Gajl-Peczalska, K.J., Sakamoto, K., Purtilo, D.T., Balfour, H.H., Simmons, R.L., and Najarian, J.S. Epstein-Barr virus-induced B-cell lymphoma after renal transplantation: Acyclovir therapy and transition from polyclonal to monoclonal B-cell proliferation. N. Engl. J. Med., 306:913, 1982.
Bieber, C. Lymphoma in cardiac transplant recipients associated with cyclosporin A, prednisone, and anti-thymocyte globulin (ATG). In: D.T. Purtilo (ed.), Immune Deficiency and Cancer: Epstein-Barr Virus and Lymphoproliferative Malignancies. New York: Plenum Press, in press.
Reece, E.R., Gartner, J.G., Seemayer, T.A., Joncas, J.H. and Pagano, J.S. Epstein-Barr virus in a malignant lympho-proliferative disorder of B cells occurring after thymic epithelial transplantation for combined immunodeficiency. Cancer Res., 41:4243, 1981.
Schubach, W.H., Hackman, R., Neiman, P.E., Miller, G., Thomas, E.D. Blood, in press.
Fox, R., McMillan, R., Spruce, W., Tani, P., and Mason, D. Analysis of T lymphocytes after bone marrow transplantation using monoclonal antibodies. Blood, 60:578, 1982.
Look, A.T., Naegle, R.F., Calihan, T., Herrod, H.G., and Henle, W. Fatal Epstein-Barr virus infection in a child with acute lymphoblastic leukemia in remission. Cancer Res., 41:4280, 1981.
Hardy, C., Harada, S., Lubin, B., Sanger, W., von Schmidt, B., Yetz, J., Saemundsen, A.K., Feusner, J., Lennette, E., Linder, J., Seeley, J.K., and Purtilo, D.T. Epstein-Barr virus (EBV) induced lymphoproliferation complicating acute lymphoblastic leukemia. J. Peds., in press.
Sonnabend, J., Witkin, S.S., and Purtilo, D.T. Acquired immunodeficiency syndrome (AIDS), opportunistic infections and malignancies in male homosexuals. A hypothesis of etiologic factors in pathogenesis. J. Am. Med. Assoc, 249:2370, 1983.
Zeigler, J.L., Wagner, G., and Greenspan, J.S. Diffuse, Undifferentiated, non-Hodgkin’s lymphoma in homosexual male — United States. Morbidity and Mortality Weekly Report, 31:277, 1982.
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Harada, S., Tatsumi, E., Lipscomb, H., Purtilo, D.T. (1984). Responses to Epstein-Barr Virus in Immune Deficient Patients. In: Purtilo, D.T. (eds) Immune Deficiency and Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4760-6_6
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DOI: https://doi.org/10.1007/978-1-4684-4760-6_6
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