Mendelian Predisposition to Lymphomagenesis

  • Henry T. Lynch
  • Guy S. Schuelke


More than 100 inherited cancer and precancer syndromes show simple Mendelian inheritance (81). Of the commonly occurring hereditary breast (82) or colon cancers (90), several differing genotypes give rise to the respective hereditary cancer syndromes. A voluminous literature on etiology of lymphomas is emerging linking genetics, immunology, and variable environmental factors.


Systemic Lupus Erythematosus Ataxia Telangiectasia Ataxia Telangiectasia Systemic Lupus Erythema Common Variable Immunodeficiency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Abo, T., Roder, J.C., Abo, W., Cooper, M.D., and Balch, C.M. Natural killer (HNK-1+) cells in Chediak-Higashi patients are present in normal numbers but are abnormal in function and morphology. J. Clin. Invest., 70:193, 1982.PubMedCrossRefGoogle Scholar
  2. 2.
    A cluster of Kaposi’s sarcoma and Pneumocystis carinii pneumonia among homosexual male residents of Los Angeles and Orange Counties, California. MMWR, 31(#23):305, 1982.Google Scholar
  3. 3.
    Ammann, A.J. and Hong, R. Disorders of the T cell system. In: E.R. Steihm and V.A. Fulginiti (eds.), Immunologic Disorders in Infants and Children. pp. 314. Philadelphia, Pa: W.B. Saunders Co., 1980.Google Scholar
  4. 4.
    Ansell, B.M. and Lawrence, J.S. A family study in lupus erythematosus, abstracted. Arth. Rheum., 6:260, 1963.Google Scholar
  5. 5.
    Arnett, F. C. and Shlman, L.E. Studies in familial systemic lupus erythematosus. Medicine, 55:313, 1976.PubMedCrossRefGoogle Scholar
  6. 6.
    Ben-Chetrit, E., Ben-Amitai, D., and Levo, Y. The association between Kaposi’s sarcoma and dysgammaglobulineraia. Cancer, 49:649, 1982.CrossRefGoogle Scholar
  7. 7.
    Berberich, F.R., Berberich, M.S., Engleman, E.G., Grumet, F.C., and King, M.-C. Hodgkin’s disease susceptibility linked to the HLA locus: classical linkage analysis and a new concordance method. Abstract #174, Am. Soc. Hum. Genet., 33d Ann Mtg, Detroit, Sept. 29 — Oct. 2, 1982.Google Scholar
  8. 8.
    Bjorkholm, M., Holm, G., DeFaire, U., and Mellstedt, H. Immunological defects in healthy twin siblings to patients with Hodgkin’s disease. Scand. J. Haematology, 19:396, 1977.CrossRefGoogle Scholar
  9. 9.
    Blattner, W.A., Dean, J.H., and Fraumeni, J.F. Familial lymphoproliferative malignancy: clinical and laboratory follow up. Ann. Int. Med., 90:943, 1979.PubMedGoogle Scholar
  10. 10.
    Blattner, W.A., Garber, D.L., Mann, L., Fisher, W., Bauman, A.W., and Fraumeni, J.F. Macroglobulinemia and autoimmune disease in a family. Abstract for Ann Mtg ASCO, C-5Q5:413, 1979.Google Scholar
  11. 11.
    Blattner, W.A., Lubiniecki, A.S., Mulvihill, J.J., Lally, P., and Fraumeni, J.F. Genetics of SV40 T-antigen expression: studies of twins, heritable syndromes and cancer families. Int. J. Cancer, 22:231, 1978.PubMedCrossRefGoogle Scholar
  12. 12.
    Block, S.R., Winfield, J.B., Lockshin, M.O., D’Angelo, W.A., and Christian, C.L. Studies of twins with systemic lupus erythematosus. A Review of the literature and presentation of 12 additional sets. Am. J. Med., 59:533, 1975.PubMedCrossRefGoogle Scholar
  13. 13.
    Bloom, D. and German, J. The syndrome of congenital telangiectatic erythema and stunted growth. J. Ped., 68:103, 1966.CrossRefGoogle Scholar
  14. 14.
    Bloom, D. and German, J. The syndrome of congenital telangiectatic erythema and stunted growth. Arch. Derm., 103:545, 1971.PubMedCrossRefGoogle Scholar
  15. 15.
    Bluefarb, S.M. Kaposi’s Sarcoma. Springfield IL., Charles C. Thomas, 1957.Google Scholar
  16. 16.
    Bowers, T.K., Moldow, C.F., Bloomfield, C.D., and Yunis, E.J. Familial Hodgkin’s disease and the major histocompatibility complex. Vox. Sang., 33:273, 1977.PubMedCrossRefGoogle Scholar
  17. 17.
    Brubaker, G., Levin, A.G., Steel, C.M., Creasley, G., Cameron, H.M., Linsell, C.A., and Smith, P.G. Multiple cases of Burkitt’s lymphoma and other neoplasms in families in the north Mara district of Tanzania. Int. J. Cancer, 261:165, 1980.CrossRefGoogle Scholar
  18. 18.
    Buehler, S.K., Firme, F., Fodor, G., Fraser, G.R., Marshall, W.H., and Vaze, P. Common variable immunodeficiency, Hodgkin’s disease, and other malignancies in a Newfoundland family. Lancet, i:195, 1975.CrossRefGoogle Scholar
  19. 19.
    Bywaters, E.G. Family studies of rheumatoid arthritis and lupus erythematosus in Great Britain. In: J.H. Kellgren (ed.), The Epidemiology of Chronic Rheumatism. A symposium organized by the Council for International Organization of Medical Sciences. Vol. 1, pp. 294–258. Philadelphia: Davis Co., 1963.Google Scholar
  20. 20.
    Byrk, D., Farman, J., Dallemand, S., Meyers, M.A., and Wecksell, A. Kaposi’s sarcoma of the intestinal tract: roentgen manifestations. Gastrointes. Radiol., 3:425, 1975.CrossRefGoogle Scholar
  21. 21.
    Walker, M., Rubinstein, P., Carrier, C., Carpenter, C., Krassner, J., and Friedman-Kien, A. The HLA system in patients with Kaposi’s sarcomas. Abstract of Annual AACHT meeting, 1982. Human Imm., 5(#2):178, 1982.CrossRefGoogle Scholar
  22. 22.
    Catovsky, D., Rose, M., Goolden, A.W.G., Shite, J.M., Bourikas, G., Brownell, A.I., Blattner, W.A., Greaves, M.F., Galton, D.A.G., McCluskey, D.R., Lampert, I., Ireland, R., Bridges, J.M., and Gallo, R.C. Adult T cell lymphoma-leukemia in blacks from the West Indies. Lancet, i:827, 1982.Google Scholar
  23. 23.
    Chused, T.M., Kassan, S.S., Opelz, G., and Moutsopoulos, H.M. Sjogren’s syndrome associated with HLA-Dw3. N. Engl. J. Med., 296:895, 1977.PubMedCrossRefGoogle Scholar
  24. 24.
    Cole, P., MacMahon, B., and Aisenberg, A. Mortality from Hodgkin’s disease in the United States: evidence for the multiple aetiology hypotheses. Lancet, ii:1371, 1968.CrossRefGoogle Scholar
  25. 25.
    Creagan, E.T. and Fraumeni, J.F., Jr. Familial Hodgkin’s disease. Lancet, ii:547, 1972.CrossRefGoogle Scholar
  26. 26.
    Dalidorf, G., Linsell, C.A., and Barnhart, F.E. An epidemiological approach to the lymphomas of African children and Burkitt’s sarcoma of the jaws. Perspect. Biol. Med., 7:435, 1964.Google Scholar
  27. 27.
    Delaney, W.E. and Balogh, K. Carcinoma of the parotid gland associated with benign lymphoepithelial lesion (Mikulicz’s disease) in Sjogren’s syndrome. Cancer, 19:853, 1966.PubMedCrossRefGoogle Scholar
  28. 28.
    Denko, C.W. and Gergenstal, D.M. The Sicca syndrome (Sjogren’s syndrome): a study of sixteen cases. Arch. Int. Med., 105:849, 1960.CrossRefGoogle Scholar
  29. 29.
    DeThé, G., Ambrosioni, J.C., Ho, H., and Kwan, H.C. Lymphoblastoid transformation and presence of herpestype viral particles in a Chinese nasopharyngeal tumor cultured in vitro. Nature, 221:770, 1969.CrossRefGoogle Scholar
  30. 30.
    Dicken, C.H., Dewald, G., and Gordon, H. Sister chromatid exchanges in Bloom’s syndrome. Arch. Derm., 114:755, 1978.PubMedCrossRefGoogle Scholar
  31. 31.
    Dworsky, R., Baptista, J., Parker, J., Chandor, S., Noble, G., Herrmann, K., Henle, W., and Henderson, B. Immune function in healthy relatives of patients with malignant disease. J. Natl. Cancer Inst., 60:27, 1978.PubMedGoogle Scholar
  32. 32.
    Dubois, E.R. Lupus Erythematosus. In: A Review of the Current Status of Discoid and Systemic Lupus Erythematosus and Their Variants. Un. of S. California Press, Los Angeles, 1974, 2nd edition.Google Scholar
  33. 33.
    Dubois, R.W., Weiner, J.M., and Dubois, E.L. Dermatoglyphic study of systemic lupus erythematosus. Arth. Rheum., 19:83, 1976.CrossRefGoogle Scholar
  34. 34.
    Epstein, E. Kaposi’s sarcoma and parapsoriasis en plaque in brothers. J. Am. Med. Assoc, 219:1377, 1972.CrossRefGoogle Scholar
  35. 35.
    Epstein, M.A. and Achong, B.G. The relationship of the virus to Burkitt’s lymphoma. In: M.A. Epstein and B.G. Achong (eds.), The Epstein-Barr Virus. New York: Springer-Verlag, 1979.CrossRefGoogle Scholar
  36. 36.
    Epstein, M.A., Achong, B.G., and Barr, Y.M. Virus particles in cultured lymphoblasts from Burkitt’s lymphoma. Lancet, i:702, 1964.CrossRefGoogle Scholar
  37. 37.
    Epstein, M.A., Hunt, R.D., and Rabin, H. Pilot experiments with EB virus in owl monkeys (Aotus trivirgatus). I. Int. J. Cancer, 12:309, 1973.CrossRefGoogle Scholar
  38. 38.
    Finlay, A.Y. and Marks, R. Familial Kaposi’s sarcoma. Br. J. Dermatol., 100:323, 1979.PubMedCrossRefGoogle Scholar
  39. 39.
    Forbes, J.F. and Morris, P.J. Analysis of HLA antigens in patients with Hodgkin’s disease and their families. J. Clin. Invest., 51:1156, 1972.PubMedCrossRefGoogle Scholar
  40. 40.
    Fraga, A., Armendares, S., Mintz, G., Mora, J., and Cortes, R. Dermatoglyphic patterns in systemic lupus erythematosus (SLE) and their changes in patients with increased fetal wastage. J. Rheum., (Suppl 1):35, 1974.Google Scholar
  41. 41.
    Fraumeni, J.F., Wertelecki, W., Blattner, W.A., Jensen, R.D., and Leventhal, B.G. Varied manifestations of a familial lymphoproliferative disorder. Am. J. Med., 59:145, 1975.PubMedCrossRefGoogle Scholar
  42. 42.
    Frizzera, G., Rosai, J., Dehner, L.P., Spector, B.D., and Kersey, J.H. Lymphoreticular disorders in primary immunodeficiencies: new findings based on an up-to-date histologic classification of 35 cases. Cancer, 46:692, 1980.PubMedCrossRefGoogle Scholar
  43. 43.
    Fye, K.H., Terasaki, P.I., Moutsopoulos, H., Danials, T.E., Michalski, J.P., and Talai, N. Association of Sjogren’s syndrome with HLA-B8. Arth. Rheum., 19:883, 1976.CrossRefGoogle Scholar
  44. 44.
    Gallo, R.C. and Wong-Staal, F. Retroviruses as etiologic agents of some animal and human leukemias and lymphomas and as tools for elucidating the molecular mechanism of leukemagenesis. Blood, 60(3);545, 1982.PubMedGoogle Scholar
  45. 45.
    German, J. Genetic disorders associated with chromosomal instability and cancer. J. Inves. Derm., 60:427, 1973.Google Scholar
  46. 46.
    German, J., Bloom, D., and Passarge, E. Bloom’s syndrome. V. Surveillance for cancer in affected families. Clin. Genet., 2: 162, 1977.Google Scholar
  47. 47.
    Gershwin, M.E., Terasaki, P.I., Graw, R. et al. Increased frequency of HL-A8 in Sjogren’s syndrome. Tis. Ant., 6:432, 1975.Google Scholar
  48. 48.
    Gerstoft, J., Malchow-Moller, A., Bygbjerg, I., Dickmeiss, E., Enk, C., Halberg, P., Haahr, S., Jackobsen, M., Jensen, K., Mejer, J., Nielsen, J.O., Thomsen, H.K., Sondergaard, J., and Lorenzen, I. Severe acquired immunodeficiency in European homosexual men. Br. Med. J., 285:17, 1982.CrossRefGoogle Scholar
  49. 49.
    Gervias, F., Wills, A., Leyritz, M., Lebrun, A., and Joncas, J.H. Relative lack of Epstein-Barr virus (EBV) receptors on B cells from persistently EBV seronegative adults. J. Immun., 126:897, 1981.Google Scholar
  50. 50.
    Gill, T.J. and Repetti, C.F. Immunologic and genetic factors influencing reproduction. Am. J. Pathol., 95:465, 1979.PubMedGoogle Scholar
  51. 51.
    Gracz, K., Kofman, S., and Economou, S.G. Hodgkin’s disease in monozygotic twins: a case report. J. Surg. Oncol., 12:221, 1979.PubMedCrossRefGoogle Scholar
  52. 52.
    Green, J.A., Dawson, A.A., and Walker, W. Systemic lupus erythematosus and lymphoma. Lancet, ii:753, 1978.CrossRefGoogle Scholar
  53. 53.
    Greene, M.H., McKeen, E.A., Li, F.P., Blattner, W.A., and Fraumeni, J.F. HLA antigens in familial Hodgkin’s disease. Int. J. Cancer, 23:117, 1979.CrossRefGoogle Scholar
  54. 54.
    Haerer, A.F., Jackson, J.F., and Evers, C.G. Ataxia telangiectasia with gastric adenocarcinoma. J. Am. Med. Assoc, 210:1884, 1969.CrossRefGoogle Scholar
  55. 55.
    Hamoudi, A.B., Ertel, I., Newton, W.A., Reiner, C.B., and Clatworthy, H.W. Multiple neoplasms in an adolescent child associated with IgA deficiency. Cancer, 33:1134, 1974.PubMedCrossRefGoogle Scholar
  56. 56.
    Hann, H.L., Kim, C.Y., London, W.T., Whitford, P., and Blumberg, B.S. Hepatitis B virus and primary hepato-cellular carcinoma: family studies in Korea. Int. J. Cancer, 30:47, 1982.PubMedCrossRefGoogle Scholar
  57. 57.
    Henle, G., Henle, W., Clifford, P., Diehl, V., Kafuko, G.W., Kirya, B.G., Klein, G., Morrow, R.H., Munube, G.M.A., Pike, P., Tukei, P.M., and Ziegler, J.L. Antibodies to Epstein-Barr virus in Burkitt’s lymphoma and control groups. J. Natl. Cancer Inst., 43:1147, 1969.PubMedGoogle Scholar
  58. 58.
    Henle, W., Henle, G., Ho, H., Burtin, P., Cachin, Y., Clifford, P., Schryver, A.P., DeThe, G., Diehl, V., and Klein, G. Antibodies to Epstein-Barr virus in nasopharyngeal carcinoma, other head and neck neoplasms and control groups. J. Natl. Cancer Inst., 44:225, 1970.PubMedGoogle Scholar
  59. 59.
    Hinuma, Y., Komoda, H., Chosa, T., Kondo, T., Kohakura, M., Takenaka, T., Kikuchi, M., Ichimaru, M., Yunoki, K., Sato, I., Matsuo, R., Takiuchi, Y., Uchimo, H., and Hanaoka, M. Antibodies to adult T cell leukemia-virus-associated antigen (ATLA) in sera from patients with ATL and controls in Japan: a nation-wide seroepidemiologic study. Int. J. Cancer, 29:631, 1982.PubMedCrossRefGoogle Scholar
  60. 60.
    Hinuma, Y., Nagata, K., Hanaoka, M.A., Nakai, M., Matsumoto, T., Kinoshita, K., Shirakaw, S., and Miyoshi, I. Adult T cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera. Proc. Natl. Acad. Sci. USA, 78:6476, 1981.PubMedCrossRefGoogle Scholar
  61. 61.
    Hirshaut, Y., Cohen, M., and Stevens, D. Serological differences between American and African Burkitt’s lymphoma. Fed. Proc, 30:301, 1971.Google Scholar
  62. 62.
    Horbar, J.D., Dickerman, J.D., Allen, E.F., and Albertini, R.J. Hodgkin’s disease following acute lymphocytic leukemia in a patient from a cancer-prone family: a case report. Med. Ped. Oncol., 9:219, 1981.CrossRefGoogle Scholar
  63. 63.
    Hutteroth, T.H., Litwin, S.D., German, J. Abnormal immune responses of Bloom’s syndrome lymphocytes in vitro. J. Clin. Invest., 56:1, 1975.PubMedCrossRefGoogle Scholar
  64. 64.
    Imamura, N., Kozaneraaru, S., and Kuramoto, A. T cell leukemia a few months apart in two brothers. Lancet, i:1361, 1982.CrossRefGoogle Scholar
  65. 65.
    Jackson, J.F. Ataxia telantiectasia. In: H.T. Lynch (ed.), Skin, Heredity, and Malignant Neoplasms. pp. 94–103. New York: Medical Examination Publishing, 1972.Google Scholar
  66. 66.
    Jones, E.H., Biggar, R.J., Nkrumah, F.K., and Lawler, S.D. Study of the HLA system in Burkitt’s lymphoma. Hum. Immun., 3:207, 1980.CrossRefGoogle Scholar
  67. 67.
    Kassan, S.S. and Gardy, M. Sjögren’s syndrome: an update and overview. Am. J. Med., 64:1037, 1978.PubMedCrossRefGoogle Scholar
  68. 68.
    King, M.C., Go, R.C.P., Elston, R.C., Lynch, H.T., and Petrakis, N.L. Allele increasing susceptibility to human breast cancer may be linked to the glutamate-pyruvate transaminase locus. Science, 208:406, 1980.PubMedCrossRefGoogle Scholar
  69. 69.
    Kirkpatrick, C.H. Cancer and immunodeficiency diseases. Birth Defects, 12:61, 1976.PubMedGoogle Scholar
  70. 70.
    Kopelovich, L., Lipkin, M., Blattner, W., Fraumeni, J.F., Lynch, H.T., and Pollack, R.E. Organization of actincontaining cables in cultured skin fibroblasts from individuals at high risk of colon cancer. Int. J. Cancer, 26:301, 1980.PubMedCrossRefGoogle Scholar
  71. 71.
    Larsen, R.A. Family studies in systemic lupus erythematosus (SLE). VI. Presence of rheumatoid factors in relatives and spouses. J. Chron. Dis., 25:191, 1972.PubMedCrossRefGoogle Scholar
  72. 72.
    Larsen, R.A. Family studies in systemic lupus erythematosus (SLE). VII. Serum immunoglobulins: IgG concentrations in relatives of selected SLE probands. J. Chron. Dis., 25:215, 1972.PubMedCrossRefGoogle Scholar
  73. 73.
    Larsen, R.A. Family studies in systemic lupus erythematosus (SLE). IX. Thyroid diseases and antibodies. J. Chron. Dis., 25:225, 1972.PubMedCrossRefGoogle Scholar
  74. 74.
    Legrand, L., Rivat-Perrah, L., Huttin, C., and Dausset, J. HLA and Gm linked genes affecting the degradation rate of antigens (sheep red blood cells) endocytized by macrophages. Human Imm., 4:1, 1982.CrossRefGoogle Scholar
  75. 75.
    Levine, P.H., Fraumeni, J.F., Jr., Reisher, J.L., and Waggoner, D.E. Antibodies to Epstein-Barr virus associated antigen in relatives of cancer patients. J. Natl. Cancer Inst., 52:1037, 1974.PubMedGoogle Scholar
  76. 76.
    Levin, S., Gottfried, E., and Cohen, M. Ataxia telangiectasia: a review with observations on 47 Israeli cases. Ped., 6:135, 1977.Google Scholar
  77. 77.
    Li, F.P. and Fraumeni, J.F., Jr. Soft tissue sarcomas, breast cancer, and other neoplasms. A familial syndrome? Ann. Int. Med., 71:747, 1969.PubMedGoogle Scholar
  78. 78.
    Li, F.P. and Fraumeni, J.F., Jr. Familial breast cancer, soft tissue sarcomas, and other neoplasms. Ann. Int. Med., 83:834, 1975.Google Scholar
  79. 79.
    Lichtenfeld, J.L., Kirschner, R.H., and Wiernick, P.H. Familial Sjögren’s syndrome with associated primary salivary gland lymphoma. Am. J. Med., 60:286, 1976.PubMedCrossRefGoogle Scholar
  80. 80.
    Louis-Bar (Mme.) Sur un syndrome progressif comprenant des telangiectasies capillaires cutanees et conjonctivales symetriques a disposition naevoide et des trobules cerebelleux. Confinia. Neurol., 4:32, 1971.Google Scholar
  81. 81.
    Lynch, H.G. Cancer Genetics. Springfield: Charles C. Thomas Co., 1976.Google Scholar
  82. 82.
    Lynch, H.T. Breast Cancer Genetics. New York: Van Nostrand Reinhold Co., 1981.Google Scholar
  83. 83.
    Lynch, H.T. and Frichot, B.C. Skin, heredity and cancer. Sem. Oncol., 5: 67, 1978.Google Scholar
  84. 84.
    Lynch, H.T. and Fusaro, R.M. Cancer Associated Genodermatoses. New York: Nostrand Reinhold Co., 1982.Google Scholar
  85. 85.
    Lynch, H.T. and Guirgis, H.A. Childhood Cancer and the SBLA syndrome. Med. Hypoth., 5:15, 1979.CrossRefGoogle Scholar
  86. 86.
    Lynch, H.T., Mulcahy, G.M., Harris, R.E., Guirgis, H.A., and Lynch, J.F. Genetic and pathologic findings in a kindred with hereditary sarcoma breast cancer, brain tumors, leukemia, lung, laryngeal, and adrenal cortical carcinoma. Cancer, 41:2055, 1974.CrossRefGoogle Scholar
  87. 87.
    Lynch. H.T., Petcharin, S., Kannika, P., and Lynch, J.F. Familial hepatocellular carcinoma in an endemic area of Thailand. Cancer Gen. and Cytogen., in press.Google Scholar
  88. 88.
    Lynch, H.T., Purtilo, D., Schuelke, G., Lynch, J.F., and Danes, B.S. Familial Hodgkin’s disease. In preparation, 1982.Google Scholar
  89. 89.
    Lynch, H.T., Saldivar, V.A., Guirgis, H.A., Terasaki, P.I., Bardawil, W.A., Harris, R.E., Lynch, J.F., and Thomas, R. Familial Hodgkin1 s disease and associated cancer: a clinical-pathological study. Cancer, 38:5:2033, 1976.PubMedCrossRefGoogle Scholar
  90. 90.
    Lynch, P.M. and Lynch. H.T. Colon Cancer Genetics. New York: Van Nostrand Reinhold Co., in press, 1983.Google Scholar
  91. 91.
    MacMahon, B. Epidemiology of Hodgkin’s disease. Cancer Res., 26:1189, 1966.PubMedGoogle Scholar
  92. 92.
    Mann, S.G. Kaposi’s sarcoma. Experience with ten cases. AJR, 121:793, 1974.Google Scholar
  93. 93.
    Marshall, W.H., Barnard, J.M., Buehler, S.K., Grumley, J., and Larsen, B. HLA in familial Hodgkin’s disease: results and a new hypothesis. Int. J. Cancer, 19:450, 1977.PubMedCrossRefGoogle Scholar
  94. 94.
    Marshall, W.H., Buehler, S.K., Grumley, J., Salmon, D., Landre, M.F., and Frazser, G.R. A familial aggregate of common variable immunodeficiency, Hodgkin’s disease and other malignancies in Newfoundland. I. Clinical features. Clin. Inves. Med., 2:153, 1980.Google Scholar
  95. 95.
    McBride, A. and Fennelly, J.J. Immunological depletion contributing to familial Hodgkin’s disease. Eur. J. Cancer, 316:549, 1977.Google Scholar
  96. 96.
    McGinn, J.T., Ricca, J.J., and Currin, J.F. Kaposi’s sarcoma following allergic angitis. Ann. Int. Med., 42:921, 1955.PubMedGoogle Scholar
  97. 97.
    Meisner, L.F., Gilbert, E., Ris, H.W., and Haverty, G. Genetic mechanisms in a cancer predisposition: a report of a cancer family. Cancer, 43:679, 1979.PubMedCrossRefGoogle Scholar
  98. 98.
    Mendius, J.R., DeHoratius, R.J., Messner, R.P., and Williams, R.C. Family distribution of lymphocytotoxins in Hodgkin’s disease. Ann. Int. Med., 84: 151, 1976.PubMedGoogle Scholar
  99. 99.
    Miller, G. Biology of Epstein-Barr virus. In: G. Klein (ed.), Viral Oncology, pp. 713–738. New York: Raven Press, 1980.Google Scholar
  100. 100.
    Mitchison, N.A., Kinlen, L.J., Akagi, T., Ohtsuki, Y., Shiraishi, Y., Nagata, K., and Hinuma, Y. Present concepts in immune surveillance. In: M. Fougereau and J. Gausset (eds.), Immunology 80. pp. 641–650. New York: Academic Press, 1980.Google Scholar
  101. 101.
    Miyoshi, I., Kulonishi, I., Yoshimoto, S. et al. Type C virus particles in a cord T cell line derived by cocultivating normal human cord leukocytes and human leukemic T cells. Nature, 294;770, 1981.PubMedCrossRefGoogle Scholar
  102. 102.
    Morrow, R.H., Pike, M.C., Smith, P.G., Ziegler, J.L., and Kisuule, A. Burkitt’s lymphoma: a time-space cluster of cases in Bwamba county of Uganda. Br. Med. J., 2:491, 1971.PubMedCrossRefGoogle Scholar
  103. 103.
    Nunez-Roldan, A., Martinez-Guibelalde, F., Gomez-Garcia, P., Gomez-Pereira, C., Nunez-Ollero, G., and Torres-Gomez, A. Possible HLA role in a family with Hodgkin’s disease. Tis. Ant., 13:377, 1979.CrossRefGoogle Scholar
  104. 104.
    Oppenheim, T.J., Sandberg, A.L., Altman, L.C., Hook, W.A., and Dougherty, S.F. Relationship of mitogen and tannins in walnuts to suppression of lymphocyte transformation after ingestion of walnuts. In: K. Lindahl-Kiessling and D. Osoba (eds.), Lymphocyte Recognition and Effector Mechanisms, pp. 79–84. New York: Academic Press, 1974.Google Scholar
  105. 105.
    Pandey, J.P., Johnson, A.H., Fudenberg, H.H., Amos, D.B., Gutterman, J.U., and Hersh, E.M. HLA antigens and immunoglobulin allotypes in patients with malignant melanoma. Human Imm., 2:185, 1981.CrossRefGoogle Scholar
  106. 106.
    Pellegris, G., Illeni, M.T., Rovini, D., Vaglini, M., Cascinelli, N., and Chidoni, A. HLA complex and familial malignant melanoma. Int. J. Cancer, 29:621, 1982.PubMedCrossRefGoogle Scholar
  107. 107.
    Peterson, R.D., Cooper, M.D., and Good, R.A. Lymphoid tissue abnormalities associated with ataxia telangiectasia. Am. J. Med., 41:342, 1966.PubMedCrossRefGoogle Scholar
  108. 108.
    Plouffe, J.F., Silvan, J., Schwartz, R.S., Callen, J.P., Kane, P., Murphy, L.A., Goldstein, I.J., and Fekety, R. Abnormal lymphocyte responses in residents of a town with a cluster of Hodgkin’s disease. Clin. Exp. Imm., 35:163, 1979.Google Scholar
  109. 109.
    Pollack, M.S., Kirkpatrick, D., Kapoor, N., Dupont, B., and O’Reilly, R.J. Identification by HLA typing of intrauterine-derived maternal T cells in four patients with severe combined immunodeficiency. N. Engl. J. Med., 307:662, 1982.PubMedCrossRefGoogle Scholar
  110. 110.
    Potolsky, A.I., Heath, C.W., Buckley, CE., and Rowlands, D.T. Lymphoreticular malignancies and immunologic abnormalities in a sibship. Am. J. Med., 50:42, 1971.PubMedCrossRefGoogle Scholar
  111. 111.
    Purtilo, D.T. Malignant lymphoproliferative diseases induced by Epstein-Barr virus in immunodeficient patients, including X-linked, cytogenetic, and familial syndromes. Cancer Genet. & Cytogenet., 4:251, 1981.CrossRefGoogle Scholar
  112. 112.
    Purtilo, D.T. and Klein, G. (eds.) Introduction to Epstein-Barr virus and lymphoproliferative diseases in immunodeficient individuals. Cancer Res., 41:4209, 1981.Google Scholar
  113. 113.
    Reedman, G.M. and Klein, G. Cellular localization of an Epstein-Barr virus (EBV)-associated complement-fixing antigen in producer and nonproducer lymphoblastoid cell lines. Int. J. Cancer, 11:499, 1973.PubMedCrossRefGoogle Scholar
  114. 114.
    Robert-Guroff, M., Nakao, Y., Notake, K., Ito, Y., Sliski, A. and Gallo, R.C. Natural antibodies to human retrovirus HTLV in a cluster of Japanese patients with adult T cell leukemia. Science, 215:975, 1982.PubMedCrossRefGoogle Scholar
  115. 115.
    Rothman, S., Block, M., and Hauser, F.V. Sjogren’s syndrome associated with lymphoblastoma and hypersplenism. Arch Derm. Syph., 63:642, 1951.Google Scholar
  116. 116.
    Safai, B. and Good, R.A. Kaposi’s sarcoma: a review and recent developments. Ca-A. Ca. J. Clinicians, 31(#1):2–12, 1982.Google Scholar
  117. 117.
    Salmon, D., Landre, M.F., Fraser, G.R., Buehler, S.K., Grunley, J., and Marshall, W.H. A familial aggregate of Hodgkin’s disease, common variable immunodeficiency, and other malignancy cases in Newfoundland. II. Geneological analysis and conclusions regarding hereditary determinants. Clin. Inves. Med., 4:175, 1979.Google Scholar
  118. 118.
    Salimonu, L.S., Bryant, D.G., Buehler, S.K., Chandra, R.K., Grumley, J., and Marshall, W.H. Immunoglobulins in familial Hodgkin’s disease and immunodeficiency in Newfoundland. Int. Arch. Allergy Appl. Imun., 63:52, 1980.CrossRefGoogle Scholar
  119. 119.
    Samitz, M.H. Dermatologic gastrointestinal relationships. In: H.L. Bockus (ed.), Gastroenterology. pp. 426–473. Philadelphia, PA: W.B. Saunders, 1976.Google Scholar
  120. 120.
    Sawitsky, A., Bloom, D., and German, J. Chromosomal breakage and acute leukemia in congenital telangiectatic erythema and stunted growth. Ann. Int. Med., 65:487, 1966.PubMedGoogle Scholar
  121. 121.
    Schuelke, G.S., Lynch, H.T., Lynch, J.F., Chaperon, E.A., Recabaren, J.A., Grabner, B., and Albano, W.A. Cellular immune function study in an ovarian cancer-prone kindred. Br. J. Cancer, in press, 1982.Google Scholar
  122. 122.
    Schuelke, G.S., Lynch, H.T., Lynch, J.F., Fain, P.R., and Chaperon, E.A. Low serum IgA in a familial ovarian cancer aggregate. Cancer Gen. & Cytogen., 6:231, 1982.CrossRefGoogle Scholar
  123. 123.
    Schwaber, J.F., Klein, G., Ernberg, I., Rosen, A., Lazanes, H., and Rosen, F.S. Deficiency of Epstein-Barr virus (EBV) receptors on B lymphocytes from certain patients with common variable agammaglobulinemia. J. Immunol., 124:2191, 1980.PubMedGoogle Scholar
  124. 124.
    Schwartz, R.S. Another look at immune surveillance. N. Engl. J. Med., 293:181, 1975.PubMedCrossRefGoogle Scholar
  125. 125.
    Seeley, J.K., Sakamoto, K., Ip, S.H., Hansen, P.W. and Purtilo, D.T. Abnormal lymphocyte subsets in X-linked lymphoproliferative syndrome. J. Immunol., 127:2618, 1981.PubMedGoogle Scholar
  126. 126.
    Setlow, R.B. Repair deficient human disorders and cancer. Nature 271:713, 1978.PubMedCrossRefGoogle Scholar
  127. 127.
    Shope T., Dechairo, D., and Miller, G. Malignant lymphoma in cotton-topped marmosets following inoculation of Epstein-Barr virus. Proc. Natl. Acad. Sci. USA, 70:2487, 1973.PubMedCrossRefGoogle Scholar
  128. 128.
    Shope, T.C., Khalifa, S., Smith, S.T., and Cushing, B. Epstein-Barr virus antibody in childhood Hodgkin’s disease. Am. J. Dis. Child., 136:701, 1982.PubMedGoogle Scholar
  129. 129.
    Sinkovics, J.G., Trujillo, J.M., Pienta, R.J., and Ahem, M.J. Leukemagenesis stemming from autoimmune disease. In; Genetic Concepts and Neoplasia. A Collection of Papers Presented at the Twenty-Third Annual Symposium on Fundamental Cancer Research. pp. 138–190. Baltimore; Williams & Wilkins, 1970.Google Scholar
  130. 130.
    Sjogren, H. Zur kenntnis der keratoconjunctivities sicca (keratitis filiformis bei hypofunktion der tranendrusen). Acta. Oph., (Suppl) 2:1, 1933.Google Scholar
  131. 131.
    Smith, C.K., Cassidy, J.T., and Bole, G.G. Type I dysgammaglobulineraia, systemic lupus erythematosus, and lymphoma. Am. J. Med., 48:113, 1970.PubMedCrossRefGoogle Scholar
  132. 132.
    Spector, B.D., Perry, G.S. and Kersey, J.H. Genetically determined immunodeficiency diseases (GDID) and malignancy: report from the Immunodeficiency Cancer Registry. Clin. Immunol. Immunopath., 11:12, 1978.CrossRefGoogle Scholar
  133. 133.
    Stein, M., Keller, S., and Schleifer, S. Role of the hypothalamus in mediating stress effects on the immune systems. In: B.A. Stoll (ed.), Mind and Cancer Prognosis. pp. 85–101. John Wiley & Sons, Ltd, 1979.Google Scholar
  134. 134.
    Stevens, D.A., O’Connor, G.T., Levine, P.H., and Rosen, R.B. Acute leukemia with “Burkitt’s lymphoma cells” and Burkitt’s lymphoma. Ann. Int. Med., 76:967, 1972.PubMedGoogle Scholar
  135. 135.
    Stiehm, E.R. The B lymphocyte system. In: E.R. Stiehm and V.A. Fulginiti (eds.), Immunologic Disorders in Infants and Children. 2nd edition, pp. 52–81. Philadelphia: W.B. Saunders, 1980.Google Scholar
  136. 136.
    Swift, M. Malignant disease in heterozygous carriers. Birth Defects, 12:133, 1976.PubMedGoogle Scholar
  137. 137.
    Swift, M. and Chase, C. Cancer in families with xeroderma pigmentosum. J. Natl. Cancer Inst., 62:1415, 1979.PubMedGoogle Scholar
  138. 138.
    Sullivan, J.L., Byron, K.S., Brewster, F.E., and Purtilo, D.T. Deficient natural killer cell activity in X-linked lymphoproliferative syndrome. Science, 210:543, 1980.PubMedCrossRefGoogle Scholar
  139. 139.
    Svejgaard, A. HLA and disease. In: N.R. Rose and H. Friedman (eds.), Manual of Clinical Immunology. 2nd Edition, pp. 1049–1058. Washington, D.C.: American Society for Microbiology, 1980.Google Scholar
  140. 140.
    Tadjoedin, M.K. and Fraser, F.C. Heredity of ataxia telangiectasia (Louis-Bar syndrome). Am. J. Dis. Child., 110:64, 1965.PubMedGoogle Scholar
  141. 141.
    Talai, N. and Bunim, J.J. The development of malignant lymphoma in the course of Sjogren’s syndrome. Am. J. Med.., 36:529, 1964.CrossRefGoogle Scholar
  142. 142.
    Templeton, A.C. and Dhru, D. Kaposi’s sarcoma in half-brothers. Trop. Geogr. Med., 17:324, 1975.Google Scholar
  143. 143.
    The T and B cell malignancy study group. Statistical analysis of immunologic, clinical and histopathologic data on lymphoid malignancies in Japan. Japan J. Clin. Oncol., 11:15, 1981.Google Scholar
  144. 144.
    Thompson, E.A. Pedigree analysis of Hodgkin’s disease in a Newfoundland genealogy. Ann. Hum. Genet., 45:279, 1981.PubMedCrossRefGoogle Scholar
  145. 145.
    Torres, A., Martinez, F., Gomez, P., Gomez, C., Garcia, J.M., and Nunez-Roldan, A. Simultaneous Hodgkin’s disease in three siblings with identical HLA genotype. Cancer, 46:838, 1980.PubMedCrossRefGoogle Scholar
  146. 146.
    Vance, J.C. Immune system evaluation in genetic immunodeficiency diseases associated with malignancies. In: H.T. Lynch and R.M. Fusaro (eds.), Cancer-Associated Genodermatoses. pp. 300–365. New York: Van Nostrand Reinhold, 1982.Google Scholar
  147. 147.
    Wright, D.H. The epidemiology of Burkitt’s tumors. Cancer Res., 27:2424, 1967.PubMedGoogle Scholar
  148. 148.
    Wolf, H., zur Hausen, H., and Becker, V. EB viral genomes in epithelial nasopharyngeal carcinoma cells. Nature New Biol., 244:245, 1973.PubMedGoogle Scholar
  149. 149.
    Zeligman, I. Kaposi’s sarcoma in a father and son. Bull. Johns-Hopkins Hosp., 107:208, 1960.PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • Henry T. Lynch
    • 1
  • Guy S. Schuelke
    • 1
  1. 1.School of Medicine, Department of Preventive MedicineCreighton UniversityOmahaUSA

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