Chronic Mononucleosis

  • Martin Tobi
  • Abraham Morag


Since its discovery in 1964 (1) and implication as the main cause of the infectious mononucleosis (IM) syndrome (2), the Epstein-Barr virus (EBV) has become a common archetype of human latent viral infections (3). This has been ascribed to its infection of B lymphocytes (4) and a resultant permanent viral carrier state (3). These genome carrying cells may give rise to continuous EBV-containing lymphoblastoid cell lines in in vitro cultures established from the peripheral blood and lymph node lymphocytes of seropositive individuals (5). With the characterization of the specific antibody responses in IM (6), their application in the elucidation of atypical cases of EBV infection became evident (7), particularly in children (8) and in 50–60% of adults where the minimal criteria for the diagnosis of IM (9) are not fulfilled (10,11). Given the high incidence of exposed individuals (80% by late adolescence), the recognized tendency of herpes viruses to reactivation (3), the persistent carrier state, and the predisposition to atypical infections, it might be expected that recurrent or prolonged atypical EBV infections would be commonly reported.


Infectious Mononucleosis Atypical Lymphocyte Viral Capsid Antigen Serological Profile Prolonged Illness 
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Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • Martin Tobi
    • 1
  • Abraham Morag
    • 2
  1. 1.Laboratory Immunology, NCINIHBethesdaUSA
  2. 2.Division of Clinical Virology, Section of VirologyHadassah-Hebrew University Medical SchoolJerusalemIsrael

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