Relationship of Immune Deficiency and Oncogenic Viruses to Malignant B Cell Lymphomas: Mouse and Man

  • Paul K. Pattengale


With the exception of the dualtropic murine leukemia virus (MuLV)-induced polymorphic B cell lymphoma in young C57BL/6 mice, and the Epstein-Barr virus (EBV)-induced polymorphic B cell lymphoma in immunodeficient patients, it is apparent that the vast majority of spontaneously occurring B cell lymphomas in immunodef icient mice and men are not causally linked to overt inducing agents (e.g., oncogenic viruses) (Table 1). For this reason, the comparative features of dualtropic MuLV-induced and EBV-induced B cell diseases are discussed, as well as the association of B cell lymphomas with congenital and acquired immunodeficiencies.


Cell Lymphoma Graft Versus Host Disease Oncogenic Virus Immunodeficient Patient Histiocytic Lymphoma 
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Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • Paul K. Pattengale
    • 1
  1. 1.Departments of Pathology and MicrobiologyUSC School of MedicineLos AngelesUSA

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