Herpesvirus-Induced Lymphoproliferative Diseases in Non-Human Primates

  • Donald R. Johnson


Non-human primate experimental models for Herpes virus-induced lymphoproliferative diseases.


Squirrel Monkey Lymphoproliferative Disease Infectious Mononucleosis Spider Monkey Common Marmoset 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Abb, J., Abb, H., and Deinhardt, F. Cell-mediated immune response of marmosets to Herpesvirus associated antigens in vitro. Cancer Immunol. Immunother., 9:219, 1980.CrossRefGoogle Scholar
  2. 2.
    Bar, R.S., Deler, C.J., Clausen, K.P., Hurtubise, P., Henle, W., and Hewetson, J.F. Fatal infectious mononucleosis in a family. N. Engl. J. Med., 290:363, 1974.PubMedCrossRefGoogle Scholar
  3. 3.
    Blazar, B., Patarroyo, M., Klein, E., and Klein, G. Increased sensitivity of human lymphoid lines to natural killer cells after induction of the Epstein-Barr viral cycle by superinfection or sodium butyrate. J. Exp. Med., 151:614, 1980.PubMedCrossRefGoogle Scholar
  4. 4.
    Britton, S., Andersson-Anvret, M., Gergely, P., Henle, W., Jondal, M., Klein, G., Sandstedt, B., and Svedmyr, E. Epstein-Barr virus immunity and tissue distribution in a fatal case of infectious mononucleosis. N. Engl. J. Med., 288:89, 1978.CrossRefGoogle Scholar
  5. 5.
    Deinhardt, F.W., Falk, L.A., and Wolfe, L.G. Simian Herpesvirus and neoplasia. In: G. Klein and S. Weinhouse (eds.), Advances in Cancer Research. Vol. 19, pp. 167–205. New York: Academic Press, 1974.Google Scholar
  6. 6.
    Deinhardt, F., Falk, L., Wolfe, L.G., Paciga, J., and Johnson, D.R. Response of marmosets to experimental infection with Epstein-Barr virus. In: G. DeThe, M.A. Epstein and H. zur Hausen (eds.), Oncogenesis and Herpesvirus II. Vol. 11, pp. 161–168. IARC Scientific Publications, 1975.Google Scholar
  7. 7.
    Epstein, M.A., Hunt, R.D., and Rabin, H. Pilot experiments with EB virus in owl monkeys (Aotus trivirgatus). I. Reticuloproliferative disease in an inoculated animal. Int. J. Cancer, 12:309, 1973.PubMedCrossRefGoogle Scholar
  8. 8.
    Falk, L.A., Wolfe, L.G., and Deinhardt, F. Isolations of Herpesvirus saimiri from blood of squirrel monkeys (Saimiri sciureus). J. Natl. Cancer Inst., 48:1499, 1972.PubMedGoogle Scholar
  9. 9.
    Falk, L.A., Nigida, S.M., Deinhardt, F., Wolfe, L.G., Cooper, R.W., and Hernandez-Camacho, J.I. Herpesvirus ateles: properties of an oncogenic Herpesvirus isolated from circulating lymphocytes of spider monkeys (Ateles sp.). Int. J. Cancer, 14:473, 1974.PubMedCrossRefGoogle Scholar
  10. 10.
    Falk, L., Deinhardt, F., Wolfe, L., Johnson, D., Hilgers, J., and DeThe, G. Epstein-Barr virus. Experimental infection of Callithrix jacchus marmosets. Int. J. Cancer, 13:785, 1976.CrossRefGoogle Scholar
  11. 11.
    Falk, L., Wolfe, L., Deinhardt, F., Paciga, J., Dombros, L., Klein, G., Henle, W., and Henle, G. Epstein-Barr virus: transformation of nonhuman primate lymphocytes in vitro. Int. J. Cancer, 13:363, 1974.PubMedCrossRefGoogle Scholar
  12. 12.
    Falk, L., Johnson, D., and Deinhardt, F. Transformation of marmoset lymphocytes in vitro with Herpesvirus ateles. Int. J. Cancer, 21:652, 1978.PubMedCrossRefGoogle Scholar
  13. 13.
    Falk, L. Personal communication.Google Scholar
  14. 14.
    Fialkow, P.J. Human tumors studied with genetic markers. Birth Defects, 12:123, 1976.PubMedGoogle Scholar
  15. 15.
    Fialkow, P.J., Klein, G., Gartier, S.M., and Clifford, P. Clonal origin for individual Burkitt tumours. Lancet, i:384, 1970.CrossRefGoogle Scholar
  16. 16.
    Fleckenstein, B., Bornkamm, G.W., and Werner, F.J. The role of Herpesvirus saimiri genomes in oncogenic transformation of primate cells. In: Comparative Leukemia Research 1975. Biblthca haemat. No. 43, pp. 308–312. Karger, Basel, 1976.Google Scholar
  17. 17.
    Frank, A., Andiman, W.A., and Miller, G. Epstein-Barr virus and nonhuman primates: natural and experimental infection. Adv. Cancer Res., 23: 171, 1976.PubMedCrossRefGoogle Scholar
  18. 18.
    Fukuhara, S. and Rowley, J.D. Chromosome 14 translocations in non-Burkitt lymphomas. Int. J. Cancer, 22:14, 1978.PubMedCrossRefGoogle Scholar
  19. 19.
    Hanto, D.W., Frizzera, G., Purtilo, D.T., Sakamoto, K., Sullivan, J.L., Saemundsen, A.K., Klein, G., Simmons, R.L., and Najarian, J.S. A clinical spectrum of lymphoproliferative disorders in renal transplant recipients and evidence for the role of the Epstein-Barr virus. Cancer Res., 41:4253, 1981.PubMedGoogle Scholar
  20. 20.
    Henle, W., Diehl, V., Hohn, G., zurHausen, H., and Henle, G. Herpes-type virus and chromosome marker in normal leuko-cytes after growth with irradiated Burkitt cells. Science, 157:1064, 1967.PubMedCrossRefGoogle Scholar
  21. 21.
    Henle, G., Henle, W., and Diehl, V. Relations of Burkitt’s tumor-associated herpes-type virus to infectious mononucleosis. Proc. Natl. Acad. Sci., 59:94, 1968.PubMedCrossRefGoogle Scholar
  22. 22.
    Hunt, R.D., Melendez, L.V., Garcia, F.G., and Trum, B.F. Pathologic features of Herpesvirus ateles lymphoma in cotton-topped marmosets (Saguinus oedipus). J. Natl. Cancer Inst., 49:1631, 1972.PubMedGoogle Scholar
  23. 23.
    Hunt, R.D., Melendez, L.V., King, N.W., Gilmore, C.E., Daniel, M.D., Williamson, M.E., and Jones, T.C. Morphology of a diseases with features of malignant lymphoma in marmosets and owl monkeys inoculated with Herpesvirus saimiri. J. Natl. Cancer Inst., 44:447, 1970.PubMedGoogle Scholar
  24. 24.
    Johnson, D.R., Klein, G., and Falk, L. Interaction of Herpesvirus ateles and Herpesvirus saimiri with primate lymphocytes. I. Selective adsorption of virus by lymphoid cells. Intervirology, 31:21, 1980.CrossRefGoogle Scholar
  25. 25.
    Johnson, D.R., Ernberg, I., and Klein, G. Interaction of Herpesvirus ateles with marmoset lymphocytes. II. Identification of target cell population and stimulation of DNA synthesis after infection in vitro. Intervirology, 14: 202, 1980.PubMedCrossRefGoogle Scholar
  26. 26.
    Johnson, D.R., Ohno, S., Kaschka-Dierich, C., Fleckenstein, B., and Klein, G. Relationship between Herpesvirus ateles-associated nuclear antigen (HATNA) and the number of virus genome equivalents in HVA-carrying lymphoid lines. J. Gen. Virol., 52:221, 1981.PubMedCrossRefGoogle Scholar
  27. 27.
    Johnson, D., Levan, G., Klein, G., Nigida, S., and Wolfe, L. Chromosomes and cell surface markers of marmoset lymphocytes and Epstein-Barr virus-transformed marmoset cell lines. Cancer Genetics and Cytogenetics, 8:101, 1980.Google Scholar
  28. 28.
    Johnson, D.R., Wolfe, L.G., Levan, G., Klein, G., Ernberg, I., and Aman, P. Epstein-Barr virus induced lymphopro-liferative disease in cotton-topped marmosets. In press.Google Scholar
  29. 29.
    Klein, G., Pearson, G., Rabson, A., Ablashi, D.V., Falk, L., Wolfe, L., Deinhardt, F., and Rabin, H. Antibody reactions to Herpesvirus saimiri (HVS)-induced early and late antigens (EA and LA) in HVS-infected squirrel, marmoset and owl monkeys. Int. J. Cancer, 12: 270, 1973.PubMedCrossRefGoogle Scholar
  30. 30.
    Klein, G. The Epstein-Barr virus and neoplasia. N. Engl. J. Med., 293:1353, 1975.PubMedCrossRefGoogle Scholar
  31. 31.
    Klein, G. and Klein, E. Immune surveillance against virus- induced tumors and non-rejectability of spontaneous tumors: contrasting consequences of host versus tumor evolution. Proc. Natl. Acad. Sci., 74:2121, 1977.PubMedCrossRefGoogle Scholar
  32. 32.
    Klein, G. Lymphoma development in mice and humans: diversity of initiation is followed by convergent cytogenetic evolution. Proc. Natl. Acad. Sci., 76:2442, 1979.PubMedCrossRefGoogle Scholar
  33. 33.
    Laufs, R. and Fleckenstein, B. Susceptibility to Herpesvirus saimiri and antibody development in Old and New World monkeys. Med. Microbiol. Immunol., 158:227, 1973.PubMedCrossRefGoogle Scholar
  34. 34.
    Laufs, R. and Melendez, L.V. Oncogenicity of Herpesvirus ateles in monkeys. J. Natl. Cancer Inst., 51:599, 1973.PubMedGoogle Scholar
  35. 35.
    Laufs, R., Steinke, H., Steinke, G., and Petzold, D. Latent infection and malignant lymphoma in marmosets (Callithrix jacchus) after infections with two oncogenic herpesviruses from primates. J. Natl. Cancer Inst., 53:195, 1974.PubMedGoogle Scholar
  36. 36.
    Leibold, W., Huldt, G., Flanagan, T.G., Anderson, M., Dalens, M., Wright, D.H., Voller, A., and Klein, G. Tumorigenicity of Epstein-Barr virus (EBV) transformed lymphoid line cells in autologous squirrel monkeys. Int. J. Cancer, 17:533, 1976.PubMedCrossRefGoogle Scholar
  37. 37.
    Manolov, G. and Manolova, Y. Marker band in one chromosome 14 from Burkitt lymphomas. Nature, 234:33, 1972.CrossRefGoogle Scholar
  38. 38.
    Marczynska, B., Falk, L., Wolfe, L., and Deinhardt, F. Transplantation and cytogenetic studies of Herpesvirus saimiri-induced disease in marmoset monkeys. J. Natl. Cancer Inst., 50:331, 1973.PubMedGoogle Scholar
  39. 39.
    Martin, L.N. and Allen, W.P. Response to primary infection with Herpesvirus saimiri in immunosuppressed juvenile and newborn squirrel monkeys. Infect. Immun., 12:528, 1975.PubMedGoogle Scholar
  40. 40.
    Masucci, M.G., Szigeti, R., Ernberg, I., Bjorkholm, M., Mellstedt, H., Henle, G., Henle, W., Pearson, G., Masucci, G., Svedmyr, E., Johansson, B., and Klein, G. Cell-mediated immune reactions in three patients with malignant lymphoproliferative diseases in remission and abnormally high Epstein-Barr virus antibody titers. Cancer Res., 41:4292, 1981.PubMedGoogle Scholar
  41. 41.
    Melendez, L.V., Daniel, M.D., Hunt, R.D., and Garcia, F.G. An apparently new herpesvirus from primary kidney cultures of the squirrel monkey (Saimiri sciureus). Lab. Anira. Care, 18: 374, 1968.Google Scholar
  42. 42.
    Melendez, L.V., Daniel, M.D., Garcia, F.G., Fraser, C.E.O., Hunt, R.D., and King, N.W. Herpesvirus saimiri. I. Further characterization studies of a new virus form from the squirrel monkey. Lab. Anim. Care, 19:372, 1969.PubMedGoogle Scholar
  43. 43.
    Melendez, L.V., Hunt, R.D., Daniel, M.D., Garcia, F.G., and Fraser, C.E.O. Herpes saimiri. II. An experimentally-induced malignant lymphoma in primates. Lab. Anim. Care, 19:378, 1969.PubMedGoogle Scholar
  44. 44.
    Melendez, L.V., Hunt, R.D., King, N.W., Barahona, H.H., Daniel, M.D., Fraser, C.E.O., and Garcia, F.G. Herpesvirus ateles, a new lymphoma virus of monkeys. Nature New Biol., 235:182, 1972.PubMedGoogle Scholar
  45. 45.
    Miller, G., Shope, T., Lisco, H., Stitt, D., and Lipman, M. Epstein-Barr virus: transformation, cytopathic changes and viral antigens in squirrel monkey and marmoset leukocytes. Proc. Natl. Acad. Sci. USA, 69:383, 1972.PubMedCrossRefGoogle Scholar
  46. 46.
    Miller, G., Shope, T., Coope, D., Waters, L., Pagano, J., Bornkamm, G.W., and Henle, W. Lymphoma in cotton-topped marmosets after inoculation with Epstein-Barr virus: tumor incidence, histologic spectrum, antibody responses, demonstration of viral DNA, and characterization of viruses. J. Exp. Med., 145:948, 1977.PubMedCrossRefGoogle Scholar
  47. 47.
    Nickerson, D., and Gergozian, N. Functional capabilities of marmoset T and B lymphocytes in primary in vitro antibody formation. Cell. Immunol., 57:408, 1981.PubMedCrossRefGoogle Scholar
  48. 48.
    Nilsson, K., Giovanella, B., Stehling, J.S., and Klein, G. Tumorigenicity in human hematopoietic cell lines in athymic nude mice. Int. J. Cancer, 19: 337, 1977.PubMedCrossRefGoogle Scholar
  49. 49.
    Nilsson, K. The nature of lymphoid cell lines and their relationship to the virus. In: M.A. Epstein and B.G. Achong (eds.), The Epstein-Barr Virus. pp. 225–281. Berlin: Springer-Verlag, 1979.CrossRefGoogle Scholar
  50. 50.
    Pearson, G., Ablashi, D., Orr, T., Rabin, H., and Armstrong, G. Intracellular and membrane immunofluorescence investigations on cells infected with Herpesvirus saimiri. J. Natl. Cancer Inst., 49:1417, 1972.PubMedGoogle Scholar
  51. 51.
    Pearson, G.R., Orr, T., Rabin, H., Cicmanec, J., Ablashi, D., and Armstrong, G. Antibody patterns to Herpesvirus saimiri-induced antigens in owl monkeys. J. Natl. Cancer Inst., 51: 1939, 1973.PubMedGoogle Scholar
  52. 52.
    Purtilo, D.T. Immune deficiency predisposing to Epstein-Barr virus-induced lymphoproliferative syndrome as a model. In: G. Klein and S. Weinhouse (eds.), Advances in Cancer Research. Vol. 34, pp. 279–312. New York: Academic Press, 1981.CrossRefGoogle Scholar
  53. 53.
    Purtilo, D.T., Sakamoto, K., Saemundsen, A.K., Sullivan, J.L., Synnerholm, A-C., Anvret, M., Pritchard, J., Sloper, C., Sieff, C., Pincott, J., Pachman, L., Rich, K., Cruzi, F., Cornet, J-A., Collins, R., Barnes, N., Knight, J., Sandstedt, B., and Klein, G. Documentation of Epstein-Barr virus infection in immunodeficient patients with life-threatening lymphoproliferative diseases by clinical, virological, and immunopathological studies. Cancer Res., 41:4226, 1981.PubMedGoogle Scholar
  54. 54.
    Rabin, H., Neubauer, R., Hopkins, R., and Levy, B. Characterization of lymphoid cell lines established from multiple Epstein-Barr virus (EBV-induced lymphomas) in a cotton-topped marmoset. Int. J. Cancer, 20:44, 1977.PubMedCrossRefGoogle Scholar
  55. 55.
    Rickinson, A.B., Moss, D.J., Wallace, L.E., Rowe, M., Misko, I.S., Epstein, M.A., and Pope, J.H. Long-term T-cell-mediated immunity to Epstein-Barr virus. Cancer Res., 41:4216, 1981.PubMedGoogle Scholar
  56. 56.
    Robinson, J.E., Brown, N., Andiman, W., Halliday, K., Francke, U., Robert, M., Andersson-Anvret, M., Horstmann, D., and Miller, B. Diffuse polyclonal B cell lymphoma during primary infections with Epstein-Barr virus. N. Engl. J. Med., 302:1293, 1980.PubMedCrossRefGoogle Scholar
  57. 57.
    Saemundsen, A.K., Berkel, A.I., Henle, W., Henle, G., Anvret, M., Sanal, Z., Ersoy, F., Caglar, M., and Klein, G. Epstein-Barr virus-carrying lymphoma in a patient with ataxia telangiectasia. Brit. Med. J., 282;425, 1981.CrossRefGoogle Scholar
  58. 58.
    Saemundsen, A.K., Purtilo, D.T., Sakamoto, K., Sullivan, J.L., Synnerholm, A-C., Hanto, D., Simmons, R., Anvret, M., Collins, R., and Klein, G. Documentation of Epstein-Barr virus infection in immunodeficient patients with life-threatening lyraphoproliferative diseases by Epstein-Barr virus complementary RNA/DNA and viral DNA/DNA hybridization. Cancer Res., 41:4237, 1981.PubMedGoogle Scholar
  59. 59.
    Sakamoto, K., Freed, H., and Purtilo, D.T. Antibody responses to Epstein-Barr virus in families with the X-linked lymphoproliferative syndrome. J. Immunol., 125:921, 1980.PubMedGoogle Scholar
  60. 60.
    Seeley, J.K., Sakamoto, K., Ip, S., Hansen, P., and Purtilo, D.T. Abnormal subsets in the X-linked lymphoproliferative syndrome. J. Immunol., 127:2618, 1981.PubMedGoogle Scholar
  61. 61.
    Shope, T., Dechairo, D., and Miller, G. Malignant lymphoma in cotton-topped marmosets after inoculation with Epstein-Barr virus. Proc. Natl. Acad. Sci. USA, 70:2487, 1973.PubMedCrossRefGoogle Scholar
  62. 62.
    Spira, G., Aman, P., Koide, N., Lundin, G., Klein, G., and Hall, K. Cell-surface immunoglobulin and insulin receptor expression in an EBV-negative lymphoma cell line and its EBV-converted sublines. J. Immunol., 126:122, 1981.PubMedGoogle Scholar
  63. 63.
    Sullivan, J.L., Byron, K., Brewster, F., and Purtilo, D.T. Deficient natural killer cell activity in the X-linked lymphoproliferative syndrome. Science, 210;543, 1980.PubMedCrossRefGoogle Scholar
  64. 64.
    Sundar, S.K., Levine, P.H., Ablashi, D.V., Leiseca, S.A., Armstrong, G.R., Cicmanec, J.L., Parker, G.A., and Nonoyama, M. Epstein-Barr virus-induced malignant lymphoma in a white-lipped marmoset. Int. J. Cancer, 27:107, 1981.PubMedCrossRefGoogle Scholar
  65. 65.
    Werner, J., Wolf, H., Apodaca, J., and zurHausen, H. Lymphoproliferative disease in a cotton-topped marmoset after inoculation with infectious mononucleosis-derived Epstein-Barr virus. Int. J. Cancer, 15:1000, 1975.PubMedCrossRefGoogle Scholar
  66. 66.
    Wright, J., Falk, L.A., Collins, D., and Deinhardt, F. Mononuclear cell fraction carrying Herpesvirus saimiri in persistently-infected squirrel monkeys. J. Natl. Cancer Inst., 57:959, 1976.PubMedGoogle Scholar
  67. 67.
    Wright, J., Falk, L.A., Wolfe, L.G., Ogden, J., and Deinhardt, F. Susceptibility of common marmosets (Callithrix jacchus) to oncogenic and attenuated strains of Herpesvirus saimiri. J. Natl. Cancer Inst., 59:1475, 1977.PubMedGoogle Scholar
  68. 68.
    Wolfe, L.G., Falk, L.A., and Deinhardt, F. Oncogenicity of Herpesvirus saimiri in marmoset monkeys. J. Natl. Cancer Inst., 47:1145, 1971.PubMedGoogle Scholar
  69. 69.
    Wolfe, L.G., and Deinhardt, F. Overview of viral oncology studies in Saguinus and Callithrix species. Prim. Med., 10:96, 1978.Google Scholar
  70. 70.
    Zech, L., Haglund, U., Nilsson, K., and Klein, G. Characteristic chromosomal abnormalities in biopsies and lymphoid cell lines from patients with Burkitt and non-Burkitt lymphomas. Int. J. Cancer, 17: 47, 1976.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • Donald R. Johnson
    • 1
  1. 1.Department of Pathology & Laboratory MedicineUniversity of Nebraska Medical CenterOmahaUSA

Personalised recommendations