Skip to main content

Biology of Epstein-Barr Virus

  • Chapter
Immune Deficiency and Cancer

Abstract

Epstein-Barr virus (EBV) has been linked to infectious mononucleosis and to the neoplasias, nasopharyngeal carcinoma and Burkitt’s lymphoma. The initial evidence of an etiologic relationship was mainly derived from seroepidemiological studies (for review see ref. 1) and confirmed by nucleic acid hybridization with biopsy materials (for review see ref. 2). The work of many laboratories contributed data which does not seem to fit into a unifying concept. This paper briefly summarizes some apparently conflicting results; from these data a hypothetical model for the biology of EBV is developed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Henle, W. and Henle, G. Seroepidemiology of the virus. In: M.A. Epstein and B.G. Achong (eds.), The Epstein-Barr Virus. pp. 62–78. New York: Springer, 1979.

    Google Scholar 

  2. Wolf, H. The biology of Epstein-Barr virus (EBV) in relation to NPC. In: Proceedings of UICC Workshop on Nasopharyngeal Carcinoma, in print, 1982.

    Google Scholar 

  3. Bayliss, C.G. and Wolf, H. The regulated expression of Epstein-Barr virus. III. Proteins specific by EBV during the lytic cycle. J. Virol., 56:105, 1981.

    Article  CAS  Google Scholar 

  4. Jondal, M. and Klein, G. Surface markers on human B and T lymphocytes. II. Presence of Epstein-Barr virus receptors on B lymphocytes. J. Exp. Med., 138:1365, 1973.

    Article  PubMed  CAS  Google Scholar 

  5. Glaser, R., Lang, C.M., Lee, K.J., Schuller, D.E., Jacobs, D., and McQuattie, C Attempt to infect nonmalignant nasopharyngeal epithelial cells from humans and squirrel monkeys with Epstein-Barr virus. J. Natl. Cancer Inst., 64:1085, 1980.

    PubMed  CAS  Google Scholar 

  6. Wolf, H. and zur Hausen, H. unpublished.

    Google Scholar 

  7. Wolf, H., zur Hausen, H., and Becker, V. EB viral genomes in epithelial nasopharyngeal carcinoma cells. Nature New Biol., 244:245, 1973.

    PubMed  CAS  Google Scholar 

  8. Desgranges, C., Wolf, H., de Thé, G., Shanmugaratnam, K., Cammoun, N., Ellouz, R., Klein, G., Lennert, K., Munoz, N., and zur Hausen, H. Nasopharyngeal carcinoma. X. Presence of Epstein-Barr genomes in separated epithelial cells of tumors in patients from Singapore, Tunisia and Kenya. Int. J. Cancer, 16: 7, 1975.

    Article  PubMed  CAS  Google Scholar 

  9. Klein, G., Giovanella, B.C., Lindahl, T., Fialkov, P.J., Singh, S., and Stehlin, J. Direct evidence for the presence of Epstein-Barr virus DNA and nuclear antigen in malignant epithelial cells from patients with poorly differentiated carcinoma of the nasopharynx. Proc. Natl. Acad. Sci. USA, 71:4737, 1974.

    Article  PubMed  CAS  Google Scholar 

  10. Bornkamm, G.W., Delius, H., Zimber, U., Hudewentz, J., and Epstein, M.A. Comparison of Epstein-Barr virus strains of different origin by analysis of the viral DNAs. J. Virol., 35:603, 1980.

    PubMed  CAS  Google Scholar 

  11. Modrow, S. and Wolf, H. Characterization of Herpesvirus saimiri and Herpesvirus ateles induced proteins. J. Gen. Virol., in press.

    Google Scholar 

  12. Wilmes, E. and Wolf, H. Der Nachweis von Epstein-Barr-virus-genomen in der Orhspeicheldruse. Laryngol-Rhinol., 60:7, 1981.

    Article  CAS  Google Scholar 

  13. Wolf, H., Wilmes, E., and Bayliss, G.J. Epstein-Barr virus: its site of persistence and its role in the development of carcinomas. In: Neth et al. (eds.), Modern Trends in Human Leukemia IV. pp. 191–196. Heidelberg, Berlin: Springer, 1981.

    Chapter  Google Scholar 

  14. Bayliss, G.J. and Wolf, H. Epstein-Barr virus-induced cell fusion. Nature, 287;164, 1980.

    Article  PubMed  CAS  Google Scholar 

  15. Bayliss, C.J. and Wolf, H. An Epstein-Barr virus early protein induces cell fusion. Proc. Natl. Acad. Sci. USA, 78: 7162, 1981.

    Article  PubMed  CAS  Google Scholar 

  16. Wolf, H., Bayliss, G.J., and Wilmes, E. Biological properties of Epstein-Barr virus. In: E. Grundmann, G.R.F. Krueger, and D.V. Ablashi (eds.), Nasopharyngeal Carcinoma. Vol. 5, pp. 101–109. Gustav Fischer Verlag -Stuttgart, 1981.

    Google Scholar 

  17. Döhnert, C. Ober lymphoepitheliale guschwulste Erkenntnisse anhand der Gewekultur und vergleichender klinischer, morphologischer under virologischer Untersuchungen. In: Sitzungsbericht der Heidelberger Akademie der Wissenschaften. Vol 3, pp. 96–168. Berlin:Springer, 1977.

    Google Scholar 

  18. Hirayama, T. and Ito, Y. A new view of the etiology of nasopharyngeal carcinoma. Preventive Medicine, 10: 614, 1981.

    Article  PubMed  CAS  Google Scholar 

  19. Wilmes, E., Wolf, H., Deinhardt, F. and Naumann, H.H. EBV serology in NPC and related malignancies. In: E. Grundman, G.R.F. Krueger, and D.V. Ablashi (eds.), Cancer Campaign. Nasopharyngeal Carcinoma. Vol. 5, pp. 145–150. Gustav Fischer Verlag — Stuttgart, 1981.

    Google Scholar 

  20. Glaser, R., Zimmermann, J., St. Jeor, S., and Rapp, F. Demonstration of a cellular inhibitor of Epstein-Barr and cytomegalovirus synthesis. Virology, 64:289, 1975.

    Article  PubMed  CAS  Google Scholar 

  21. Graessmann, A., Wolf, H., and Bornkamm, G.W. Expression of Epstein-3arr virus genes in different cell types after microinjection of viral DNA. Proc. Natl. Acad. Sci. USA, 77:433, 1980.

    Article  PubMed  CAS  Google Scholar 

  22. Birnboim, H.C. DNA strand breakage in human leukocytes exposed to a tumour promoter, phorbol myristate acetate. Science, 215:1247, 1982.

    Article  PubMed  CAS  Google Scholar 

  23. Burkitt, D.P. Etiology of Burkitt’s lymphoma — an alternative hypothesis to a vectored virus. J. Natl. Cancer Inst., 42:19, 1969.

    PubMed  CAS  Google Scholar 

  24. Manolova, Y., Manolov, G., Keiler, J., Levan, A., and Klein, G. Pseudo-Burkitt lymphoma marker 14 in lymphoblastoid cell lines. Hereditas, 90:5, 1979.

    Article  PubMed  CAS  Google Scholar 

  25. Klein, G. Lymphoma development in mice and humans: diversity of initiation is followed by convergent cytogenetic evolution. Proc. Natl. Acad. Sci. USA, 76:1221, 1979.

    Article  Google Scholar 

  26. Purtilo, D.T. Epstein-Barr-virus-induced oncogenesis in immune-deficient individuals. Lancet, i: 300, 1980.

    Article  Google Scholar 

  27. Purtilo, D.T. Immune deficiency predisposing to Epstein-Barr virus-induced lymphoproliferative diseases: the X-linked lymphoproliferative syndrome as a model. In: G. Klein and S. Weinhouse (eds.), Advances in Cancer Research. Vol. 34, pp. 279–312. New York: Academic Press, 1980.

    Google Scholar 

  28. Morgan, D.G., Miller, G., Niedermann, J.C., Smith, H.W., and Dowaliby, J.M. Site of Epstein-Barr virus replication in the oropharynx. Lancet, ii:1154, 1979.

    Article  Google Scholar 

  29. Wolfe, II., Haus, M., and Wilmes, E. Submitted.

    Google Scholar 

  30. zur Hausen, H., Bornkamm, G.W., Schmidt, R., and Hecker, E. Tumor initiators and promoters in the induction of Epstein-Barr virus. Proc. Natl. Acad. Sci. USA, 76:782, 1979.

    Article  PubMed  Google Scholar 

  31. Institute of Virology, Beijing. A study on the serum level of complement fixing antibody to EB virus in groups of individuals of Guangdong province and Beijing. Chinese J. Otorhinolaryngol., 13:23, 1978.

    Google Scholar 

  32. Jaenisch, R. Retroviruses and embryogenes is: microinjection of Moloney leukemia virus into midges tation mouse embryos. Cell, 19:181, 1980.

    Article  PubMed  CAS  Google Scholar 

  33. Seigneurin, J.-M., Vuillaume, M., Lenoir, G., and de The, G. Replication of Epstein-Barr virus: ultrastructural and immunofluorescent studies of P3HRl-superinfected Raji cells. J. Virol., 24:836, 1977.

    PubMed  CAS  Google Scholar 

  34. Finerty, S., Jarvis, J.E., Epstein, M.A., Tramper, P.A., Ball, G., and Giovanella, B.C. Cytogenetics of malignant epithelial cells and lymphoblastoid cell lines from nasopharyngeal carcinoma. Br. J. Cancer, 37:231, 1978.

    Article  PubMed  CAS  Google Scholar 

  35. Glaser, R., de The, G., Lenoir, G., and Ho, J.H. Superinfection of epithelial nasopharyngeal carcinoma cells with Epstein-Barr virus. Proc. Natl. Acad. Sci. USA, 73:960, 1976.

    Article  PubMed  CAS  Google Scholar 

  36. Kintner, C.H. and Sugden, B. Identification of antigenic determinants unique to the surfaces of cells transformed by Epstein-Barr virus. Nature, 294:458, 1981.

    Article  PubMed  CAS  Google Scholar 

  37. Reitz, M.S., Jr., Popovic, M., Kalyanaraman, V.S., Robert-Guroff, M., Broder, S., Mann, D., and Gallo, R.C. Human T-cell leukemia-lymphoma virus (HTLV): presence in a T-cell subset from infected patients. In: R. Neth, R. Gallo, T. Graf, K. Mannweiler, and K. Winkler (eds.), Modern Trends in Human Leukemia. Vol. IV. Berlin: Springer-Verlag, in press.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Plenum Publishing Corporation

About this chapter

Cite this chapter

Wolf, H. (1984). Biology of Epstein-Barr Virus. In: Purtilo, D.T. (eds) Immune Deficiency and Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4760-6_11

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-4760-6_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4762-0

  • Online ISBN: 978-1-4684-4760-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics