Immune Deficiency, Epstein-Barr Virus (EBV) and Lymphoproliferative Disorders

  • David T. Purtilo


This book presents data regarding mechanisms of immunity against and the resulting spectrum of Epstein-Barr virus (EBV) diseases which can ensue depending on the type and degree of immune deficiency occurring in an individual patient. Focus is on lymphoproliferative diseases, especially opportunistic malignant B cell lymphomas, occurring in predisposed immune deficient individuals. However, a growing spectrum of diseases have been recently associated with EBV (1). Empirical evidence that immune deficiency is important in lymphomagenesis stems from reports of lymphomas in renal transplant recipients and in children with inherited immunodeficiency (2).


Renal Transplant Recipient Immune Deficiency Acquire Immune Deficiency Syndrome Burkitt Lymphoma Lymphoproliferative Disease 
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  1. 1.
    Editorial. New clinical manifestations of Epstein-Barr virus infection. Lancet, ii:1253, 1982.Google Scholar
  2. 2.
    Purtilo, D.T. and Klein, G. Introduction to Epstein-Barr virus and lymphoproliferative diseases in immunodeficient individuals. Cancer Res., 41:4209, 1981.PubMedGoogle Scholar
  3. 3.
    Schwartz, R.S. Epstein-Barr virus-oncogen or mitogen? N. Engl. J. Med., 2:1307, 1980.CrossRefGoogle Scholar
  4. 4.
    Penn, I. Allograft Transplant Cancer Registry. In: D.T. Purtilo (ed.), Immune Deficiency and Cancer: Epstein-Barr Virus and Lymphoproliferative Malignancies. New York: Plenum Press, 1983.Google Scholar
  5. 5.
    Sonnabend, J.A., Witkin, S.S., and Purtilo, D.T. The Syndrome of acquired immunodeficiency. An explanation for its occurrence among homosexual men. In: D.T. Purtilo (ed.), Immune Deficiency and Cancer: Epstein-Barr Virus and Lymphoproliferative Malignancies. New York: Plenum Press, 1983.Google Scholar
  6. 6.
    Drew, M.L., Mintz, L. Miner, R. C. Sands, M., and Ketterer, B. Cytomegalovirus and Kaposi’s sarcoma in young homosexual men. Lancet, i:125, 1982.CrossRefGoogle Scholar
  7. 7.
    Purtilo, D.T. Epstein-Barr virus-induced oncogenesis in immune deficient individuals. Lancet, i:300, 1980.CrossRefGoogle Scholar
  8. 8.
    Howley, P.M. The human papillomaviruses. Arch. Path. Lab. Med., 106:429, 1982.PubMedGoogle Scholar
  9. 9.
    Purtilo, D.T. Viruses, tumors, and immune deficiency. Lancet, i:684, 1982.Google Scholar
  10. 10.
    Purtilo, D.T., Sakamoto, K., Barnabei, V., Seeley, J., Bechtold, T., Rogers, G., Yetz, J., and Harada, S. Epstein-Barr virus-induced diseases in males with the X-linked lymphoproliferative syndrome (XLP). Am. J. Med., 73:49, 1982.PubMedCrossRefGoogle Scholar
  11. 11.
    Hanto, D.W., Frizzera, G., Purtilo, D.T., Sakamoto, K., Sullivan, J.L., Saemundsen, A.K., Klein, G., Simmons, R.L., and Najarian, J.S. Clinical spectrum of lymphoproliferative disorders in renal transplant recipients and evidence for the role of Epstein-Barr virus. Cancer Res., 41:4253, 1981.PubMedGoogle Scholar
  12. 12.
    Bieber, C.P., Heberling, R.L., Jamieson, S.W., Oyer, P.E., Cleary, M., Warnke, R., Saemundsen, A., Klein, G., Henle, W., and Stinson, E.B. Lymphoma in cardiac transplant recipients. Association with the use of cyclosporin A, prednisone and antithymocyte globulin (ATG). In: D.T. Purtilo (ed.), Immune Deficiency and Cancer: Epstein-Barr Virus and Lymphoproliferative Malignancies. New York: Plenum Press, 1983.Google Scholar
  13. 13.
    Burkitt, D. P. A sarcoma involving the jaws in African children. Br. J. Surg., 46:218, 1958.PubMedCrossRefGoogle Scholar
  14. 14.
    Epstein, M.A., Achong, B.G., and Barr, Y.M. Virus particles in cultured lymphoblasts from Burkitt’s lymphoma. Lancet, i:702, 1964.CrossRefGoogle Scholar
  15. 15.
    R.E.F. Matthews (ed.) Classification and Nomenclature of Viruses. New York: Karger, 1982.Google Scholar
  16. 16.
    Henle, W., Henle, G., and Lennette, E.L. The Epstein-Barr virus. Sci. Am., 241:48, 1979.PubMedCrossRefGoogle Scholar
  17. 17.
    Lindahl, T., Adams, A., Bjursell, G., Bornkamm, S.W., Kaschka-Dietrich, E., and Jehn, U. J. Mol. Biol., 102:511, 1976.CrossRefGoogle Scholar
  18. 18.
    Heller, M., Henderson, A., and Kieff, E. Repeat array in Epstein-Barr virus DNA is related to cell DNA sequences interspersed on human chromosomes. Proc. Natl. Acad. Sci. USA, 79:5916, 1982PubMedCrossRefGoogle Scholar
  19. 19.
    Klein, G. Immune and non-immune control of neoplastic development: contrasting effects of host and tumor evolution. Cancer, 45:2486, 1980.PubMedCrossRefGoogle Scholar
  20. 20.
    Dalla-Favera, R., Bregni, M., Erikson, J., Patterson, D., Gallo, R.C., and Croce, C.M. Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells. Proc. Natl. Acad. Sci. USA, 79:7824, 1982.PubMedCrossRefGoogle Scholar
  21. 21.
    Rowley, J.D. Identification of the constant chromosome regions involved in human hematologic malignant disease. Science, 216:749, 1982.PubMedCrossRefGoogle Scholar
  22. 22.
    Hamilton, J.K., Pacquin, L.A., Sullivan, J.L., Maurer, H.S., Cruzi, P.G., Provisor, A.J., Steuber, C.P., Hawkins, E., Yawn, D., Cornet, J., Clausen, K., Finkelstein, G.Z., Landing, B., Grunnet, M., and Purtilo, D.T. X-linked Lymphoproliferative Syndrome Registry Report. J. Pedi., 96:669, 1980.CrossRefGoogle Scholar
  23. 23.
    Ochs, H.D., Sullivan, J.L., Wedgewood, R.J., Seeley, J.K., Sakamoto, K., and Purtilo, D.T. X-linked lymphoproliferative syndrome: abnormal antibody responses to bacteriophage ØX174. In: R. Wedgwood and F. Rosen (eds.), Primary Immunodeficiency Diseases. New York: Alan R. Liss, 1983.Google Scholar
  24. 24.
    Sakamoto, K., Seeley, J.K., and Purtilo, D.T. Persistent active infection of Epstein-Barr virus in carrier females of the X-linked lymphoproliferative syndrome. In: H. Shiota, Y-C. Cheng, and W.H. Prusoff (eds.), Proceedings of the International Symposium on Herpesviruses: Clinical, Pharmacological and Basic Aspects. pp. 375–379. Amsterdam-Oxford Princeton: Exerpta Medica, 1982.Google Scholar
  25. 25.
    Harada, S., Sakamoto, K., Seeley, J.K., Lindsten, T., Rogers, G., Pearson, G., and Purtilo, D.T. Immune deficiency in the X-linked lymphoproliferative syndrome. I. Epstein-Barr virus-specific defects. J. Immunol., 129:2532, 1982.PubMedGoogle Scholar
  26. 26.
    Lindsten, T., Seeley, J.K., Sakamoto, K., Yetz, J., Harada, S., Bechtold, T., Rogers, G., and Purtilo, D.T. Immune deficiency in the X-linked lymphoproliferative syndrome. II. Immunoregulatory T cell defects. J. Immunol., 129:2536, 1982.PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • David T. Purtilo
    • 1
  1. 1.Pathology & Laboratory MedicineUniversity of Nebraska Medical CenterOmahaUSA

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