Thymosin β4 is one of several peptides that have been isolated from thymosin fraction 5, a preparation from calf thymus whose properties have been discussed by Low and Goldstein (Chapter 1, this volume). Following the demonstration that thymosin fraction 5 was a mixture of many peptides, ranging in molecular weight from 1000 to 14,000 and in isoelectric point from 4.0 to 7.0 (Goldstein et al., 1977; Low et al., 1979) and the elegant isolation and structural analysis of several of these peptides by Goldstein and his co-workers (Goldstein et al., 1977; Low and Goldstein, 1979; Low et al., 1981), we became interested in the mechanism of their biochemical synthesis.
KeywordsPeritoneal Macrophage Bony Fish Preimmune Serum Vertebrate Classis Thymic Hormone
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- Goldstein, A. L., Low, T. L. K., McAdoo, M., McClure, J., Thurman, J. B., Rossio, J., Lai, C.-Y., Chang, D., Wang, S. S., Harvey, C., Ramel, A. H., and Meienhofer, Jr., 1977, Thymosin α1: Isolation and sequence analysis of an immunologically active thymic polypeptide, Proc. Natl. Acad. Sci. USA 74:725–729.PubMedCrossRefGoogle Scholar