Effect of Thymosin Fraction 5 on Purine Enzymes and Surface Markers in Lymphocytes from Normal Individuals and Homosexuals with Acquired Immune Deficiency Syndrome
Thymosin fraction 5 has numerous immunomodulatory effects, including the induction of Ly-123+ phenotype expression from Thy-1+ mouse thymocytes (Ahmed et al., 1978) and augmentation of E-rosette-forming cells in both cancer patients (Schafer et al., 1976) and children with primary immunodeficiencies (Wara et al., 1975). In addition, thymosin has been shown to induce various enzyme changes in lymphocytes, such as the appearance of TdT in mouse bone marrow (Pazmino et al., 1978) and elevations in 5′-nucleotidase (5′-NT) in human thymocytes (Cohen et al., 1981).
KeywordsAcquire Immune Deficiency Syndrome Adenosine Deaminase Enzyme Change Acquire Immune Deficiency Syndrome Patient Peripheral Blood Mononuclear
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- Ahmed, A., Smith, A. H., and Sell, K. W., 1978, Maturation of thymus-derived (T) cells under the influence of thymosin, in: Immune Modulation and Control of Neoplasia by Adjuvant Therapy (M. A. Chirigos, ed.), Vol. 7, pp. 293–324, Raven Press, New York.Google Scholar
- Galli, V., and Schlessinger, M, 1974, The formation of stable rosettes after neuraminidase treatment of either human peripheral blood lymphocytes or sheep red blood cells, J. Immunol. 112:1628–1634.Google Scholar
- Giblett, E. R., Anderson, J. E., Cohen, F., Pollara, B., and Menwissen, J. H., 1972, Adenosine deaminase deficiency in two patients with severely impaired cellular immunity, Lancet 2:1607–1609.Google Scholar
- Gottlieb, M. S., Schroff, R., Schanker, H. M., Weisman, J. D., Fan, P. T., Wold, R. A., and Saxon, A., 1981, Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men: Evidence of a new acquired cellular immunodeficiency, N. Engl. J. Med. 305:1425–1430.PubMedCrossRefGoogle Scholar
- Janossy, G., Tidman, N., Papageorgiou, E. S., Kung, P. C, and Goldstein, G., 1980, Distribution of T lymphocyte subsets in the human bone marrow and thymus: An analysis by monoclonal antibodies, J. Immunol. 126:1608.Google Scholar
- Schafer, L. A., Gutterman, J. U., Hersh, E. M., Mavligit, G. M., Dandridge, K., Cohen, G., and Goldstein, A. L., 1976, Partial restoration by in vivo thymosin of E-rosettes and delayed type hypersensitivity reactions in immunodeficient cancer patients, Cancer Immunol. Immunother. 1:259–264.Google Scholar
- Schafer, L. A., Gutterman, J. U., Hersh, E. M., Mavligit, G. M., and Goldstein, A. L., 1977, In vitro and in vivo studies of thymosin activity in cancer patients, in: Immune Modulation and Control of Neoplasia by Adjuvant Therapy (M. A. Chirigos, ed.), Vol. 2, p. 329, Raven Press.Google Scholar