Effect of Thymosin Fraction 5 on Purine Enzymes and Surface Markers in Lymphocytes from Normal Individuals and Homosexuals with Acquired Immune Deficiency Syndrome

  • J. L. Murray
  • J. M. Reuben
  • C. G. Munn
  • E. M. Hersh
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


Thymosin fraction 5 has numerous immunomodulatory effects, including the induction of Ly-123+ phenotype expression from Thy-1+ mouse thymocytes (Ahmed et al., 1978) and augmentation of E-rosette-forming cells in both cancer patients (Schafer et al., 1976) and children with primary immunodeficiencies (Wara et al., 1975). In addition, thymosin has been shown to induce various enzyme changes in lymphocytes, such as the appearance of TdT in mouse bone marrow (Pazmino et al., 1978) and elevations in 5′-nucleotidase (5′-NT) in human thymocytes (Cohen et al., 1981).


Acquire Immune Deficiency Syndrome Adenosine Deaminase Enzyme Change Acquire Immune Deficiency Syndrome Patient Peripheral Blood Mononuclear 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • J. L. Murray
    • 1
  • J. M. Reuben
    • 1
  • C. G. Munn
    • 1
  • E. M. Hersh
    • 1
  1. 1.Department of Clinical Immunology and Biological Therapy, M. D. Anderson Hospital and Tumor InstituteThe University of Texas System Cancer CenterHoustonUSA

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