Clinical Aspects of Thymulin (FTS)

  • Jean-François Bach
  • Mireille Dardenne
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


Thymulin, formerly called FTS (facteur thymique sérique), is a peptide initially prepared from porcine serum but also isolated to purity from human serum and calf thymus.


Experimental Allergic Encephalomyelitis Mycosis Fungoides Ataxia Telangiectasia Thymic Epithelial Cell Common Variable Immunodeficiency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Amor, B., Dougados, M., Mery, C., De Gery, A., Choay, J., Dardenne, M., and Bach, J.-F., 1984, Thymulin (FTS) in rheumatoid arthritis, Arthritis Rheum. 27:117.PubMedCrossRefGoogle Scholar
  2. Bach, J.-F., 1983, Spivn In: Clinics in Immunology and Allergy ,Vol. 3, p. 133, Saunders, Philadelphia.Google Scholar
  3. Bach, J.-F., Dardenne, M., and Salomon, J. C., 1973, Studies on thymus products. IV. Absence of serum thymic activity in adult NZB and (NZB × NZW)F1 mice, Clin. Exp. Immunol. 14:247.PubMedGoogle Scholar
  4. Bach, J.-F., Bach, M. A., Blanot, D., Bricas, E., Bricas, D., Charreire, J., Dardenne, M., Fournier, C., and Pléau, J. M., 1978, Thymic serum factor (FTS), Bull. Inst. Pasteur (Paris) 76:325.Google Scholar
  5. Bach, M. A., 1974, Transient loss of theta antigen after indomethacin treatment, Ann. Immunol. 125c:325.Google Scholar
  6. Bach, M. A., Droz, D., Noël, L. H., Blanchard, D., Dardenne, M., and Pekin, A., 1980, Effect on murine lupus of long term treatment with circulating thymic factor, Arthritis Rheum.23:1351.PubMedCrossRefGoogle Scholar
  7. Bordigoni, P., Faure, G., Bene, M. C., Dardenne, M., Bach, J.-F., Duheille, J., and Olive, D., 1982, Improvement of cellular immunity and IgA production in immunodeficient children after treatment with synthetic thymic factor (FTS), Lancet 2:293.PubMedCrossRefGoogle Scholar
  8. Burton, P., Iden, S., Mitchell, K., and White, A., 1978, Thymic hormone-like restoration by human prealbumin of azathioprine sensitivity of spleen cells from the thymectomized mice, Proc. Natl.Acad. Sci. USA 75:823.PubMedCrossRefGoogle Scholar
  9. Dardenne, M., 1983, Evaluation of thymic hormone serum levels in health and disease, in: Clinics in Immunology and Allergy, Vol. 3, p. 157, Saunders, Philadelphia.Google Scholar
  10. Dardenne, M., and Bach, J.-F., 1977, Demonstration and characterization of a serum factor produced by activated T cells, Immunology 33:643.PubMedGoogle Scholar
  11. Dardenne, M., Pléau, J. M., and Bach, J.-F., 1980, Evidence for the presence of a carrier of a serum thymic factor (FTS), Eur. J. Immunol. 10:83.PubMedCrossRefGoogle Scholar
  12. Dardenne, M., Pléau, J. M., Nabarra, B., Lefrancier, P., Derrien, M., Choay, J., and Bach, J.-F., 1982, Contribution of zinc and other metals to the biological activity of the serum thymic factor (FTS), Proc. Natl. Acad. Sci. USA 79:5370.PubMedCrossRefGoogle Scholar
  13. Dardenne, M., Savino, W., Gastinel, L. N., Nabarra, B., and Bach, J.-F., 1983, Thymic dysfunction in the mutant diabetic (db/db) mouse, J. Immunol. 130:1195.PubMedGoogle Scholar
  14. Faure, G., Bordigoni, P., Bene, M. C., Olive, D., and Duheille, J., 1983, Thymic factor therapy of primary T lymphocyte immunodeficiencies, in: Serono Symposium, Academic Press, New York.Google Scholar
  15. Gualde, N., Rigaud, M., and Bach, J.-F., 1982, Stimulation of prostaglandin synthesis by the serum factor (FTS), Cell. Immunol. 70:362.PubMedCrossRefGoogle Scholar
  16. Israel-Biet, N., Noël, L. H., Bach, M. A., Dardenne, M., and Bach, J.-F., 1983, Marked reduction of DNA antibody production and glomerulopathy in (FTS-Zn) and cyclosporin A-treated (NZB x NZW)F1 mice, Clin. Exp. Immunol. 54:359–365.PubMedGoogle Scholar
  17. Nagai, Y., Osanai, T., and Sakakibara, K., 1982, Intensive suppression of experimental allergic encephalomyelitis (EAE) by serum thymic factor and therapeutic implication, Jpn. J. Exp. Med. 52:213.PubMedGoogle Scholar
  18. Pléau, J. M., Dardenne, M., Blanot, D., Bricas, E., and Bach, J.-F., 1979, Antagonistic analogue of serum thymic factor (FTS) interacting with the FTS cellular receptor, Immunol. Lett. 1:179.CrossRefGoogle Scholar
  19. Pléau, J. M., Fuentes, V., Morgat, J. L., and Bach, J.-F., 1980, Specific receptor for the serum thymic factor (FTS) in lymphoblastoid cultured cell line, Proc. Natl. Acad. Sci. USA 77:2861.PubMedCrossRefGoogle Scholar
  20. Savino, W., Dardenne, M., Papiernik, M., and Bach, J.-F., 1982, Thymic hormone-containing cells: Characterization and localization of serum thymic factor in young mouse thymus studied by monoclonal antibodies, J. Exp. Med. 156:628.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Jean-François Bach
    • 1
  • Mireille Dardenne
    • 1
  1. 1.INSERM U-25Hôpital NeckerParisFrance

Personalised recommendations