Effect of Thymosin on in Vitro Immune Function in Patients with Rheumatoid Arthritis
The pathogenesis of rheumatoid arthritis (RA) is not known, but an abnormality in immunoregulation is thought to play a role. Some of the immunological abnormalities associated with other autoimmune diseases have been reported to be normalized in vitro by exposure of peripheral blood lymphocytes (PBL) to thymosin fraction 5 (TF5) (Horowitz et al., 1977 Scheinberg et al., 1979; Lavastida et al., 1981; Goldstein et al., 1976), thus providing a rationale for the use of this immunomodulating agent in these disorders. The studies being presented today were undertaken to evaluate the effect of TF5 on in vitro immunoregulatory function in patients with RA and establish the relevance of clinical application of thymosin in the treatment of this common disease.
KeywordsRheumatoid Arthritis Rheumatoid Arthritis Patient Suppressor Cell Suppressor Cell Activity Suppressor Cell Function
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