Advertisement

Effect of Thymosin on in Vitro Immune Function in Patients with Rheumatoid Arthritis

  • Robert P. Jacobs
  • Christine S. E. Richardson
  • Susan B. Riley
  • Marion Zatz
  • Janelle Hatcher
  • Allan L. Goldstein
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)

Abstract

The pathogenesis of rheumatoid arthritis (RA) is not known, but an abnormality in immunoregulation is thought to play a role. Some of the immunological abnormalities associated with other autoimmune diseases have been reported to be normalized in vitro by exposure of peripheral blood lymphocytes (PBL) to thymosin fraction 5 (TF5) (Horowitz et al., 1977 Scheinberg et al., 1979; Lavastida et al., 1981; Goldstein et al., 1976), thus providing a rationale for the use of this immunomodulating agent in these disorders. The studies being presented today were undertaken to evaluate the effect of TF5 on in vitro immunoregulatory function in patients with RA and establish the relevance of clinical application of thymosin in the treatment of this common disease.

Keywords

Rheumatoid Arthritis Rheumatoid Arthritis Patient Suppressor Cell Suppressor Cell Activity Suppressor Cell Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Abdou, N. I., Lindsley, H. B., Racela, L. S., Pascual, E., and Hassanein, K. M., 1981, Suppressor T-cell dysfunction and antisuppressor cell antibody in active early rheumatoid arthritis, J. Rheum. 8:9.PubMedGoogle Scholar
  2. Burmester, G. R., Yu, D. T. Y., Irani, A. M., Kunkel, H. G., and Winchester, R. J., 1981, 1a + T-cells in synovial fluid and tissues of patients with rheumatoid arthritis, Arthritis Rheum.24:1370.PubMedCrossRefGoogle Scholar
  3. Chattopadhyay, C., Chattopadhyay, H., Natvig, J. B., and Melbye, O. J., 1979, Rheumatoid synovial lymphocytes lack concanavalin-A-activated suppressor cell activity, Scand. J. Immunol. 10:479.PubMedCrossRefGoogle Scholar
  4. Doubloug, J. H., Chattopadhyay, C., Forre, O., Hoyeraal, H. M., and Natvig, J. B., 1981, Con A-induced suppressor cell activity and T-lymphocyte of patients with rheumatoid arthritis and juvenile rheumatoid arthritis, Scand. J. Immunol. 13:367.CrossRefGoogle Scholar
  5. Espinoza, L. R., Gaylord, S. W., Bergen, L., Vasey, F. B., Germain, B. F., and Osterland, C. K., 1980, The “active” rosette test in rheumatoid arthritis: Correlation with disease activity, Clin.Immunol. Immunopathol. 17:110.PubMedCrossRefGoogle Scholar
  6. Fineman, S. M., Mudawwar, F. B., and Geha, R. S., 1979, Characteristics and mechanisms of action of the concanavalin-A activated suppressor cell in man, Cell. Immunol. 45:120.PubMedCrossRefGoogle Scholar
  7. Goldstein, A. L., Thurman, G. B., Cohen, G. H., and Rossio, H., 1976, The endocrine thymus: Role for thymosin in the treatment of autoimmune disease, Ann. N.Y. Acad. Sci. 274:390.PubMedCrossRefGoogle Scholar
  8. Horowitz, S., Borcherding, W., Moorthy, A. V., Chesney, R., Schulte-Wisserman, H., Hong, R., and Goldstein, A. L., 1977, Induction of suppressor T-cells in systemic lupus erythematosus by thymosin and cultured thymic epithelium, Science 197:999.PubMedCrossRefGoogle Scholar
  9. Janossy, G., Panayi, G., Duke, O., Bofill, M, Poulter, L. W., and Goldstein, G., 1981, Rheumatoid arthritis: A disease of T-lymphocyte/macrophage immunoregulation, Lancet 2:839.PubMedCrossRefGoogle Scholar
  10. Keystone, E. C., Gladman, D. C., Buchanan, R., Cane, D., and Poplonski, L., 1980, Impaired antigen-specific suppressor cell activity in patients with rheumatoid arthritis, Arthritis Rheum.23:1246.PubMedCrossRefGoogle Scholar
  11. Lavastida, M. I., Goldstein, A. L., and Daniels, J. C., 1981, Thymus administration in autoimmune disorders, Thymus 2:287.PubMedGoogle Scholar
  12. Moutsopoulos, H., Fye, K. H., Sawada, S., Becker, M. J., Goldstein, A., and Talal, N., 1976, Invitro effect of thymosin on T-lymphocyte rosette formation in rheumatic diseases, Clin. Exp.Immunol. 26:573.Google Scholar
  13. Reinherz, E. L., and Schlossman, S. F., 1980, Regulation of the immune response-inducer and suppressor T-lymphocyte subsets in human beings, N. Engl. J. Med. 303:370.PubMedCrossRefGoogle Scholar
  14. Ropes, M. W., Bennett, G. A., Cobb, S., Macox, R., and Jessar, R. A., 1958, Diagnostic criteria for rheumatoid arthritis, Bull. Rheum. Dis. 9:175.PubMedGoogle Scholar
  15. Scheinberg, M. A., Cathcart, E. S., and Goldstein, A. L., 1979, Thymosin induced reduction of null cells in peripheral blood lymphocytes of patients with systemic lupus erythematosus, Lancet 1:424.Google Scholar
  16. Shou, L., Schwartz, S. A., and Good, R. A., 1976, Suppressor cell activity after concanavalin A treatment of lymphocytes from normal donors, J. Exp. Med. 143:1100.PubMedCrossRefGoogle Scholar
  17. Tosato, G., Steinberg, A. D., and Blaese, R. M., 1981, Defective EBV-specific suppressor T-cell function in rheumatoid arthritis, N. Engl. J. Med. 305:1238.PubMedCrossRefGoogle Scholar
  18. Veys, E. M., Hermanns, P. L., Goldstein, G., Kung, P., Schindler, J., and Van Wauwe, J., 1981, T-cell subpopulations determined by monoclonal antibodies in RA—Influence of immunomodulating agents, Adv. Inflammation Res. 3:155.Google Scholar
  19. Waldmann, T. A., Blaese, R. M., Broder, S., and Krakauer, R. S., 1978, Disorders of suppressor immunoregulatory cells in the pathogenesis of immunodeficiency and autoimmunity, Ann. Intern.Med. 88:225.Google Scholar
  20. Zilko, P. J., Dawkins, R. L., and Carrano, J. A., 1980, Nonspecific suppression and genetic factors in autoimmunity, in: Immunoregulation and Autoimmunity (R. W. Krakauer and M. K. Cathcart, eds.), pp. 173–181, Elsevier/North-Holland, Amsterdam.Google Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Robert P. Jacobs
    • 1
  • Christine S. E. Richardson
    • 1
  • Susan B. Riley
    • 1
  • Marion Zatz
    • 2
  • Janelle Hatcher
    • 2
  • Allan L. Goldstein
    • 2
  1. 1.Department of MedicineThe George Washington University School of Medicine and Health SciencesUSA
  2. 2.Department of BiochemistryThe George Washington University School of Medicine and Health SciencesUSA

Personalised recommendations