Thymosin Fraction 5 Treatment of Patients with Cellular Immunodeficiency Disorders
Restoration of cellular immunity in children with primary immunodeficiency disorders is best achieved by bone marrow transplantation from a histocompatible donor. In the absence of such a donor, there is no consistent source of cells or factors to reconstitute these patients. Fetal thymus transplantation may result in partial restoration of cellular immunity (Ammann et al., 1975). Steele et al. (1972) suggested that the fetal thymus produces a factor(s) capable of rapidly reconstituting cellular immunity in infants with Di George syndrome following transplantation in a cell-impermeable chamber.
KeywordsCellular Immunity Primary Immunodeficiency Ataxia Telangiectasia Primary Immunodeficiency Disease Allogeneic Cell
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