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Thymosin Fraction 5 Treatment of Patients with Cellular Immunodeficiency Disorders

  • D. W. Wara
  • M. J. Cowan
  • A. J. Ammann
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)

Abstract

Restoration of cellular immunity in children with primary immunodeficiency disorders is best achieved by bone marrow transplantation from a histocompatible donor. In the absence of such a donor, there is no consistent source of cells or factors to reconstitute these patients. Fetal thymus transplantation may result in partial restoration of cellular immunity (Ammann et al., 1975). Steele et al. (1972) suggested that the fetal thymus produces a factor(s) capable of rapidly reconstituting cellular immunity in infants with Di George syndrome following transplantation in a cell-impermeable chamber.

Keywords

Cellular Immunity Primary Immunodeficiency Ataxia Telangiectasia Primary Immunodeficiency Disease Allogeneic Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Ammann, A. J., Wara, D. W., Salmon, S., and Perkins, H., 1973, Thymus transplantation: Permanent reconstitution of cellular immunity in a patient with sex-linked combined immunodeficiency, N.Engl. J. Med. 289:5–9.PubMedCrossRefGoogle Scholar
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • D. W. Wara
    • 1
  • M. J. Cowan
    • 1
  • A. J. Ammann
    • 1
  1. 1.Pediatric ImmunologyUniversity of CaliforniaSan FranciscoUSA

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